BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 31, 2024
Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression disease activity. As B cell differentiation autoantibody production exacerbate disease, signaling pathways these processes were explored.
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Aug. 24, 2023
The proper transfer of genetic information from DNA to RNA protein is essential for cell-fate control, development, and health. Methylation DNA, RNAs, histones, non-histone proteins a reversible post-synthesis modification that finetunes gene expression function in diverse physiological processes. Aberrant methylation caused by mutations or environmental stimuli promotes various diseases accelerates aging, necessitating the development therapies correct disease-driver imbalance. In this Review, we summarize operating system across central dogma, which includes writers, erasers, readers, reader-independent outputs. We then discuss how dysregulation contributes neurological disorders, cancer, aging. Current small-molecule compounds target modifiers show modest success certain cancers. methylome-wide action lack specificity lead undesirable biological effects cytotoxicity, limiting their therapeutic application, especially with monogenic cause different directions changes. Emerging tools capable site-specific manipulation hold great promise solve dilemma. With refinement delivery vehicles, these new are well positioned advance basic research clinical translation field.
Language: Английский
Citations
56
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 26, 2024
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.
Language: Английский
Citations
25
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: June 23, 2023
Abstract Pathogens or danger signals trigger the immune response. Moderate response activation removes pathogens and avoids excessive inflammation tissue damage. Histone demethylases (KDMs) regulate gene expression play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal of KDMs is closely associated with pathogenesis various inflammatory diseases such as liver fibrosis, lung injury, autoimmune diseases. Despite becoming exciting targets for diagnosing treating these diseases, role enzymes regulation still unclear. Here, we review underlying mechanisms through which immune-related pathways responses. In addition, also discuss future applications inhibitors
Language: Английский
Citations
29
Circulation Research, Journal Year: 2025, Volume and Issue: 136(2), P. 232 - 254
Published: Jan. 16, 2025
Access to excess dietary sodium has heightened the risk of cardiovascular diseases, particularly affecting individuals with salt sensitivity blood pressure. Our research indicates that innate antigen-presenting immune cells contribute rapid pressure increases in response intake. Emerging evidence suggests epigenetic reprogramming, subsequent transcriptional and metabolic changes, allows these have a sustained repetitive stimuli. Epigenetic mechanisms also steer T-cell differentiation signaling. Immune respond environmental nutritional cues, such as salt, promoting regulation changes. This article aims identify discuss role system contributing salt-sensitive hypertension.
Language: Английский
Citations
1
EBioMedicine, Journal Year: 2025, Volume and Issue: 113, P. 105593 - 105593
Published: Feb. 12, 2025
Language: Английский
Citations
1
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 263 - 277
Published: Jan. 3, 2024
Language: Английский
Citations
8
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(3)
Published: March 1, 2024
The interplay between the immune system and metabolic state of a cell is intricate. In all phases an response, corresponding changes shall occur to support its modulation, in addition signalling through cytokine environment receptor stimulation. While autoimmune disorders may develop because imbalance that modulates switching T-cell phenotypes, effects interaction T B cells have on one another's cellular metabolism are yet be understood disease context. Here, we propose perspective which highlights potential targeting modulate T- B-cell subtypes populations as well T-B B-T interactions successfully treat disorders. Specifically, envision how can tip balance interactions, definite mechanisms both health disease, explain phenotype switches cells. Within this scenario, highlight link inflammation, immunometabolism, epigenetics ageing, critical understand inflammatory combination treatments cause (T/B) imbalances, pathways involved, increase effectiveness treatment disorders, and/or ameliorate their symptoms improve patients' quality life.
Language: Английский
Citations
7
Rheumatology Science and Practice, Journal Year: 2023, Volume and Issue: 61(4), P. 397 - 420
Published: Aug. 31, 2023
Two fundamental pathologic processes are central to the spectrum of chronic inflammation mechanisms: autoimmunity and autoinflammation. Autoimmunity autoinflammation mutually potent processes; their development is considered within framework “immunoinflammatory” continuum, reflecting close relationship between innate acquired types immune response. leading mechanism pathogenesis a large group inflammatory human diseases, defined as autoimmune frequency which in population exceeds 10%. Advances molecular biology, pharmacogenetics bioinformatics have created prerequisites for individualization therapy rheumatic diseases concept personalized medicine. The study immunopathogenesis mechanisms, improvement diagnostics, deciphering nature taxonomy, approaches prevention among priority directions medicine 21st century.
Language: Английский
Citations
16
Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(12)
Published: Dec. 1, 2023
Abstract Background Autoimmune diseases (AD) are severe pathophysiological ailments that stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression AD, thus providing significant insight into regulatory mechanism microRNA (miRNA). miRNAs short, non‐coding RNAs have been identified as essential contributors post‐transcriptional regulation host genome expression crucial regulators a myriad biological processes such immune homeostasis, T helper cell differentiation, central peripheral tolerance, development. Aims This article tends deliberate conceptualize brief pathogenesis pertinent well miRNA networks affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), lupus erythematosus (SLE) inflammatory bowel disorder (IBD) thereby novel miRNA‐based theranostic interventions. Results & Discussion Pertaining differential attributed in target tissues cellular bodies innate adaptive immunity, paradigm scientific expeditions suggests optimistic correlation between dysfunction alterations. Conclusion Therefore, it is not astonishing dysregulations patterns now recognized wide spectrum disorders, establishing themselves potential biomarkers therapeutic targets. Owing its potencies, targets widely utilized development biosensors other molecules originating from same.
Language: Английский
Citations
15
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: April 9, 2024
Multiple myeloma (MM) is an incurable hematological disease characterized by the uncontrolled growth of plasma cells primarily in bone marrow. Although its treatment consists administration combined therapy regimens mainly based on immunomodulators and proteosome inhibitors, MM remains incurable, most patients suffer from relapsed/refractory with poor prognosis survival. The robust results achieved immunotherapy targeting MM-associated antigens CD38 CD319 (also known as SLAMF7) have drawn attention to development new immune-based strategies different innovative compounds MM, including monoclonal antibodies, antibody-drug conjugates, recombinant proteins, synthetic peptides, adaptive cellular therapies. In this context, Syndecan1 (CD138 or SDC1), a transmembrane heparan sulfate proteoglycan that upregulated malignant cells, has gained increasing panorama target antigens, since key role tumorigenesis, progression aggressiveness been largely reported. Here, our aim provide overview important aspects investigate molecular functions CD138 physiologic cell states. addition, we will shed light CD138-based therapeutic approaches currently being tested preclinical and/or clinical phases discuss their properties, mechanisms action applications.
Language: Английский
Citations
4