BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 31, 2024
Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression disease activity. As B cell differentiation autoantibody production exacerbate disease, signaling pathways these processes were explored.
Language: Английский
Journal of Leukocyte Biology, Journal Year: 2024, Volume and Issue: unknown
Published: April 16, 2024
Abstract Total glucoside of peony and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia lactiflora Pallas, exhibit potent immunomodulatory effects. has been shown to inhibit inflammatory responses disease progression in experimental models multiple autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, psoriasis, so on. shows broad effects on many immune cells, such as T macrophages, dendritic by regulating their activation, proliferation, differentiation, production effector molecules. Mechanistically, total modulates intracellular signaling transductions, JAK/STAT, NF-κB, MAPK, PI3K/AKT/mTOR pathways. Moreover, applied clinical treatment various diseases with satisfactory therapeutic outcomes minor side Thus, available studies have demonstrated that bioactive constituents anti-inflammatory functions may extensive applications diseases.
Language: Английский
Citations
4
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 29, 2025
As a member of the Activator Protein-1 (AP-1) transcription factor family, Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BATF not only plays pivotal roles innate adaptive responses but also acts as crucial differentiation function various cells. Lines evidence indicate is associated with onset progression allergic diseases, graft-versus-host disease, tumors, autoimmune diseases. This review summarizes development cells, well immunoregulatory effects which may enhance current understanding pathogenesis diseases facilitate new therapeutic strategies.
Language: Английский
Citations
0
The Journal of Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Abstract Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in the humoral response. However, epigenetic enzymes programs that govern their rapid differentiation incompletely understood. Here, of histone H3 lysine 27 methyltransferase EZH2 formation MBC response influenza infection was determined Mus musculus. expressed all postactivated B-cell subsets, including antibody-secreting (ASC), maximal expression germinal center (GC) cells. Deletion resulted a skewing pool towards non-GC, IgM+ subset failed fully express CCR6 CD73 at both early late time points. Intriguingly, although protein levels were reduced knockout MBC, deletion not efficient, indicating strong selective pressure maintain activity. Single-cell RNA-seq antigen-specific identified core set upregulated genes likely targets across subsets. Finally, defects ability form secondary ASC GC lethal challenge observed EZH2-deficient mice, significant impairment absence EZH2. These data show is critical modulator potential during reactivation.
Language: Английский
Citations
0
Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)
Published: April 29, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1537 - 1537
Published: May 1, 2025
Immune cytopenias, such as autoimmune hemolytic anemia, immune thrombocytopenia, and Evans syndrome, are characterized by autoantibodies targeting various blood cells, initiating their destruction. Interactions between T B ultimate maturational plasma cell descendants, dendritic macrophages result in antibody production, including the autoreactive ones. Autoimmune phenomena can be idiopathic or associated with dysregulation conditions malignancies. Interventions disrupting this complex network at different levels have been used to treat cytopenias certain of success. Some cases known refractory many therapeutic approaches, ones eliminating cells. In some cases, cells resulted disease control. Among compartments, unique long-lived (LLPCs) residing primarily bone marrow, specialized antibody-producing an extended lifespan, capable persistently secreting antibodies. LLPCs evade conventional strategies designed target often-proliferating Research focusing on role has provided evidence for role, sustained production autoantibodies. Frequent genetic mutations progression other entities reported a group children cytopenias. This might provide new insights potential underlying epigenetic mechanisms leading generation maintenance disorders. We brief review LLPC biology future implications article.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6102 - 6102
Published: March 23, 2023
Epidemiological evidence supports an association between cow’s milk consumption and the risk of diffuse large B-cell lymphoma (DLBCL), most common non-Hodgkin worldwide. This narrative review intends to elucidate potential impact milk-related agents, predominantly milk-derived exosomes (MDEs) their microRNAs (miRs) in lymphomagenesis. Upregulation PI3K-AKT-mTORC1 signaling is a feature DLBCL. Increased expression B cell 6 (BCL6) suppression lymphocyte-induced maturation protein 1 (BLIMP1)/PR domain-containing (PRDM1) are crucial pathological deviations Translational indicates that during breastfeeding period, human MDE miRs support proliferation via epigenetic upregulation BCL6 (via miR-148a-3p-mediated DNA methyltransferase (DNMT1) miR-155-5p/miR-29b-5p-mediated activation-induced cytidine deaminase (AICDA) BLIMP1 let-7-5p/miR-125b-5p-targeting PRDM1). After weaning with physiological termination miR signaling, infant’s declines, whereas BLIMP1-mediated for adequate own antibody production rises. Because bovine share identical nucleotide sequences, pasteurized adults continued transfer bioactive may de-differentiate cells back neonatal “proliferation-dominated” phenotype maintaining increased BLC6/BLIMP1 ratio. Persistent milk-induced dysregulation thus represent novel driving mechanism Bovine MDEs cargo have be considered pathogens should removed from food chain.
Language: Английский
Citations
10
Journal of Leukocyte Biology, Journal Year: 2023, Volume and Issue: 115(1), P. 57 - 67
Published: May 3, 2023
Abstract Sjögren's syndrome is a systemic autoimmune disease characterized by dysfunction of the affected exocrine glands. Lymphocytic infiltration within inflamed glands and aberrant B-cell hyperactivation are two salient pathologic features in syndrome. Increasing evidence indicates that salivary gland epithelial cells act as key regulator pathogenesis syndrome, revealed dysregulated innate immune signaling pathways epithelium increased expression various proinflammatory molecules well their interaction with cells. In addition, can regulate adaptive responses nonprofessional antigen-presenting promote activation differentiation infiltrated Moreover, local inflammatory milieu modulate survival cells, leading to enhanced apoptosis pyroptosis release intracellular autoantigens, which further contributes SG inflammation tissue destruction Herein, we reviewed recent advances elucidating role may provide rationales for potential therapeutic targeting alleviate alongside treatments immunosuppressive reagents
Language: Английский
Citations
10
Immunological Reviews, Journal Year: 2024, Volume and Issue: 323(1), P. 61 - 79
Published: March 1, 2024
Summary NK cells are short‐lived innate lymphocytes that can mediate antigen‐independent responses to infection and cancer. However, studies from the past two decades have shown acquire transcriptional epigenetic modifications during inflammation result in increased survival lifespan. These findings blur lines between adaptive arms of immune system, suggest homeostatic mechanisms govern persistence malleable. Indeed, recent undergo continuous strictly regulated adaptations controlling their development, tissue residency, following inflammation. In this review, we summarize our current understanding critical factors regulating cell throughout lifespan, with a specific emphasis on regulate various contexts. A precise molecular will be important enhance therapies for cancer infectious diseases.
Language: Английский
Citations
3
Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 428 - 428
Published: April 16, 2025
Chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), atherosclerosis, and bowel disease (IBD), pose major global health concerns. These disorders are marked by persistent inflammation, immune system dysfunction, tissue injury, fibrosis, ultimately leading to severe organ dysfunction diminished quality of life. Osteopontin (OPN), a multifunctional extracellular matrix protein, plays crucial role in regulation, remodeling. It promotes cell recruitment, stimulates pro-inflammatory cytokine production, contributes fibrosis through interactions with integrins CD44 receptors. Additionally, OPN activates key pathways, including NF-κB, MAPK, PI3K/Akt, further aggravating damage chronic conditions. Our review highlights the its potential biomarker, therapeutic implications. We explore promising preclinical approaches, monoclonal antibodies, small molecule inhibitors, natural compounds like curcumin, which have demonstrated mitigating OPN-driven inflammation. However, challenges persist selectively targeting while maintaining essential physiological roles, bone remodeling wound healing. offers insights into strategies future research directions.
Language: Английский
Citations
0
Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)
Published: July 31, 2023
Abstract Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive growth. In combination with immune checkpoint blockade (ICB), epigenetic modification-targeted drugs are emerging as attractive cancer treatments. Lysine-specific demethylase 1 (LSD1) is a protein that modifies histone non-histone proteins known to influence wide variety physiological processes. The dysfunction LSD1 contributes poor prognosis, patient survival, drug resistance, immunosuppression, etc., making it potential target for therapy. This review examines how modulates different cell behavior TME emphasizes use inhibitors ICB therapy future research studies.
Language: Английский
Citations
8