Macromolecular Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Abstract
In
this
study,
a
thermoresponsive
double‐network
(DN)
nanocomposite
hydrogel
is
developed.
The
primary
network
comprises
Pluronic
P123,
while
the
secondary
gelatinmethacrylate
(GELMA)
and
polyacrylamide
(PAM).
A
systematic
approach
adopted
to
develop
DN
hydrogels.
Initially,
impact
of
P123
concentrationon
mechanical
properties
PAM‐GELMA
investigated.
Results
from
tensile
strength
oscillatory
shear
tests
reveal
that
an
increasing
concentration
has
marginal
effect
on
storage
modulus
significantly
reducing
loss
hydrogel,
thereby
improving
properties.
Notably,
DN3
containing
7.5w/v%
in
exhibits
osteoid
matrix‐like
To
further
enhance
properties,
citrate‐containing
amorphous
calcium
phosphate
(ACP_CIT)
incorporated
at
varying
concentrations.
At
lower
ACP_CIT
(0.75
w/v%),
DN3‐ACP0.75
are
notably
enhanced.
Incorporating
(DN3‐ACP0.75)
decreases
creep
strain,
rapid
stress
relaxation,
reduced
water
uptake
capacity
maintaining
behavior.
Finally,
vitro
analysis
confirms
cytocompatibility
hydrogels
with
MC3T3‐E1
cells,
indicating
potential
use
bone
tissue
engineering.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: June 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Regeneration
of
diabetic
bone
defects
remains
a
formidable
challenge
due
to
the
chronic
hyperglycemic
state,
which
triggers
accumulation
advanced
glycation
end
products
(AGEs)
and
reactive
oxygen
species
(ROS).
To
address
this
issue,
we
have
engineered
bimetallic
metal–organic
framework-derived
Mn@Co3O4@Pt
nanoenzyme
loaded
with
alendronate
Mg2+
ions
(termed
MCPtA)
regulate
microenvironment
recover
osteogenesis/osteoclast
homeostasis.
Notably,
Mn
atom
substitution
in
Co3O4
nanocrystalline
structure
could
modulate
electronic
significantly
improve
SOD/CAT
catalytic
activity
for
ROS
scavenging.
By
integration
GOx-like
Pt
nanoparticles,
MCPtA
achieved
effective
multiple
cascade
performance
that
facilitated
clearance
glucose
ROS.
Furthermore,
was
encapsulated
within
glucose-responsive
hydrogel
cross-linked
via
borate
ester
bond,
termed
PAM,
evaluate
potential
composite
cranial
defect
repair
rats.
The
vitro/vivo
experiments
as
well
RNA
sequencing
analysis
demonstrated
disrupt
glucose-ROS-induced
inflammation
promoted
osteogenesis
angiogenesis,
consequence,
improving
therapeutic
effects
regeneration.
This
study
provided
crucial
insights
into
nanoenzyme-mediated
microenvironmental
regulation
Mineral
nanoparticles
and
osteoinductive
biomaterials
are
essential
in
advancing
bone
regeneration
by
addressing
skeletal
conditions
injuries
that
compromise
structural
integrity
functionality.
These
stimulate
the
differentiation
of
precursor
cells
into
osteoblasts,
creating
biocompatible
environments
conducive
to
tissue
regeneration.
Among
most
promising
innovations,
mineral-based
nanocomposite
hydrogels
have
emerged
as
effective
strategies
for
enhancing
potential.
This
review
explores
diverse
types
biomaterials,
including
natural
sources,
synthetic
compounds,
hybrid
designs
incorporate
mineralized
nanoparticles.
Emphasis
is
placed
on
polymeric
delivery
platforms
these
materials,
highlighting
their
dual
role
supports
bioactive
agents
promote
osteogenesis.
Challenges
such
immune
rejection,
biodegradability,
mechanical
stability,
short
vivo
residence
time
critically
discussed,
alongside
impact
clinical
translation.
By
presenting
a
comprehensive
analysis
mechanisms,
applications,
limitations,
this
identifies
opportunities
integrating
with
emerging
fields
like
immunology
biomechanics.
Ultimately,
work
aims
provide
actionable
insights
advance
development
novel,
clinically
relevant
solutions
improve
patient
outcomes
address
growing
global
need
repair
Gels,
Journal Year:
2024,
Volume and Issue:
10(6), P. 362 - 362
Published: May 24, 2024
Nanocomposite
gels
consist
of
nanoparticles
dispersed
in
a
gel
matrix.
The
main
aim
this
work
was
to
develop
nanocomposite
for
topical
delivery
Flurbiprofen
(FB)
humans
and
farm
animals.
were
prepared
stemming
from
(NPs)
freeze-dried
with
two
different
cryoprotectants,
D-(+)-trehalose
(NPs-TRE)
polyethylene
glycol
3350
(NPs-PEG),
sterilized
by
gamma
(γ)
irradiation,
gelled
Sepigel®
305.
FB-NPs-TRE
FB-NPs-PEG
physiochemically
characterized
terms
appearance,
pH,
morphological
studies,
porosity,
swelling,
degradation,
extensibility,
rheological
behavior.
drug
release
profile
kinetics
assessed,
as
well
as,
the
ex
vivo
permeation
FB
assessed
human,
porcine
bovine
skin.
In
studies
healthy
human
volunteers
tested
without
assess
tolerance
nanoparticles.
Physicochemical
demonstrated
suitability
formulations.
skin
capacity
FB-NPs
cryoprotectants
allowed
us
conclude
that
these
formulations
are
suitable
systems
veterinary
medicine.
However,
there
statistically
significant
differences
each
formulation
depending
on
Results
suggested
most
skin,
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Effective
treatment
of
bone
diseases
is
quite
tricky
due
to
the
unique
nature
tissue
and
complexity
repair
process.
In
combination
with
biological
materials,
cells
factors
can
provide
a
highly
effective
safe
strategy
for
regeneration,
especially
based
on
these
multifunctional
hydrogel
interface
materials.
However,
itis
still
challenge
formulate
materials
fascinating
properties
(e.g.,
activity,
controllable
biodegradability,
mechanical
strength,
excellent
cell/tissue
adhesion,
release
properties)
their
clinical
applications
in
complex
processes.
this
review,
we
will
highlight
recent
advances
developing
functional
hydrogels.
We
then
discuss
barriers
producing
without
sacrificing
inherent
properties,
potential
cartilage
are
discussed.
Multifunctional
serve
as
fundamental
building
block
engineering.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 1, 2025
ABSTRACT
Tissue
engineering
is
a
vast
expanding
field
with
applications
in
areas
such
as
tissue/organ
transplantation,
drug
delivery,
vitro
models,
and
so
on.
Biomaterials
form
an
essential
component
tissue
by
acting
template
for
cellular
activity,
therefore,
novel
tissue‐engineered
biomaterials
innovative
properties
are
high
demand.
Hence,
this
work
proposes
interpenetrating
polymer
network
cryogel
of
chitosan
hydroxyethyl
methacrylate
(HEMA)
biomaterial
uniform
cell
seeding
throughout
the
matrix.
The
physical
analysis
cryogels
demonstrated
highly
macroporous
structure
exhibiting
pore
size
distribution
overall
porosity
through
emission‐scanning
electron
microscopy
(FE‐SEM)
sizes
lying
range
50–200
μm
150–400
horizontal
transverse
plane,
respectively.
were
also
found
to
be
degradable
average
percent
degradation
17.28
±
1.47%
4
weeks,
their
mechanical
revealed
compressive
strength
0.05
MPa
elastic
modulus
3
MPa.
Further,
biological
characterization
direct
contact
test
depicted
excellent
biocompatibility
L929
mouse
fibroblast
MC3T3‐E1
preosteoblasts
negligible
presence
dead
cells
around
cryogel.
Uniform
increasing
proliferation
trend
was
observed
on
these
live‐dead
staining
MTT
assay
at
day
1,
3,
7‐time
point.
Cell
adherence
studies
via
FE‐SEM
similar
along
flattened
morphology
extracellular
matrix
production.
Therefore,
based
promising
physico‐chemical
properties,
HEMA‐Chitosan
exhibit
strong
potential
application
engineered
biomaterials.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(4)
Published: March 28, 2025
ABSTRACT
Bone
repair
is
a
complex
biological
process
requiring
dynamic
interplay
between
cellular
mechanisms,
molecular
signaling,
and
environmental
factors.
The
intricate
stages
of
bone
healing,
including
hematoma
formation,
inflammation,
soft
callus
development,
hard
remodeling,
are
driven
by
coordinated
responses
pathways.
Proinflammatory
cytokines,
growth
factors,
the
extracellular
matrix
play
critical
roles
in
promoting
osteogenesis
angiogenesis.
Factors
such
as
age,
systemic
health,
mechanical
stability
significantly
influence
efficiency.
To
address
limitations
natural
advancements
regenerative
medicine
have
introduced
innovative
materials
like
nanocomposite
hydrogels,
which
mimic
microenvironment
enhance
function.
Semi‐interpenetrating
network
(semi‐IPN)
hydrogels
emerged
promising
tool
for
tissue
engineering.
Combining
crosslinked
non‐crosslinked
polymers,
these
offer
balance
stability,
functionality,
controlled
degradation.
Semi‐IPN
provide
structural
support,
facilitate
cell
attachment,
enable
sustained
release
bioactive
molecules.
Their
flexibility
adaptability
make
them
suitable
encapsulating
stem
cells
targeted
regeneration.
Moreover,
nonsurgical
surgical
scaffold
delivery
methods,
ranging
from
injectable
to
3D‐printed
magnetically
guided
scaffolds,
expanded
horizons
strategies,
reduced
invasiveness,
improved
patient
outcomes.
This
review
explores
dynamics
role
regeneration,
advanced
construction
strategies
semi‐IPN
repair.
By
integrating
polymer
science,
nanotechnology,
bioengineering,
represent
transformative
shift
addressing
defects,
paving
way
therapeutic
approaches
medicine.
With
ongoing
advancements,
technologies
hold
significant
potential
improve
effectiveness
accessibility
solutions.
