Clinical biomarker profiles reveals gender differences and mortality factors in sepsis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 21, 2024

Background Sepsis is a major contributor to global morbidity and mortality, affecting millions each year. Notwithstanding the decline in sepsis incidence mortality over decades, gender disparities outcomes persist, with research suggesting higher rates males. Methods This retrospective study aims delineate gender-specific clinical biomarker profiles impacting progression by examining cases related data from past three years. Propensity score matching was used select age-matched healthy controls for comparison. Results Among 265 patients, significantly proportion were male (60.8%, P<0.001). While did not differ gender, deceased patients older (mean 69 vs 43 years, P=0.003), more likely have hypertension (54% 25%, P=0.019), had SOFA scores ~10 4, P<0.01) compared survivors. Principal Component Analysis (PCA) showed clear separation between controls. 48 serum biomarkers altered sepsis, Triiodothyronine, Apolipoprotein A, Serum cystatin C having highest diagnostic value ROC analysis. Gender-stratified comparisons identified male-specific (e.g. AFP, HDLC) female-specific Rheumatoid factor, Interleukin-6) biomarkers. Deceased differed survivors, 22 differentially expressed markers; Antithrombin, Prealbumin, HDL cholesterol, Urea nitrogen Hydroxybutyrate efficiency mortality. Conclusion These findings enhance our understanding of may guide future therapeutic strategies. Further warranted validate these investigate molecular mechanisms underlying differences outcomes.

Language: Английский

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Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 4, 2025

Prior research indicates a potential link between dyslipidemia and endometriosis (EMs). However, the relationship remnant cholesterol (RC) EMs has not been thoroughly investigated. Consequently, looking into clarifying connection RC was primary goal of this study. Following screening participants from NHANES dataset spanning 2001 to 2006, total 1,840 individuals were incorporated research. A weighted multivariable logistic regression analysis first performed investigate relation likelihood encountering EMs. To assess degree consistency in across different populations, additional subgroup analyses performed. In addition, researchers used extreme gradient boosting (XGBoost) technique area under receiver operating characteristic curve (ROC) evaluate how well recognized Lastly, both linear nonlinear relationships validated using generalized additive models (GAM), while dose-response connections investigated through restricted cubic spline models. After accounting for all confounders, strong correlation identified. particular, an increase one unit linked 135% rise developing Analyses subgroups revealed that these remained stable majority (interaction P-value > 0.05). Multivariable demonstrated RC's independent predictive value, maintaining statistical significance after adjusting confounders. The AUC 0.614 suggests moderate ability discriminate EMs, outperforming traditional markers like LDL-C sensitivity specificity. Furthermore, XGBoost identified as most critical predictor among lipid-related demographic variables. further GAM, which visually confirmed trend, RCS, provided evidence linearity. This study reveals clear having within US population, suggesting marker investigation understanding risk.

Language: Английский

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Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background The focus on remnant cholesterol (RC) has intensified because of its association with various diseases. In this study, we investigated the between RC and depression in middle-aged older adults. Methods study involved 7,305 participants from 2015 2018 waves China Health Retirement Longitudinal Study. Based 10-item Center for Epidemiological Studies Depression Scale (CESD-10), was indicated by scores ≥ 12. To assess correlation levels depression, a logistic regression model that incorporated restricted cubic spline techniques used. Results Of population, (mean age: 60.0 ± 9.5 years), 50.3% were female. From to 2018, mean CESD-10 score increased 6.31 3.56 7.85 5.23. Following adjustment confounding factors, individuals higher level quartile exhibited risk (Q3: odds ratio [OR]: 1.75, 95% confidence intervals [CI]: 1.29–2.39; Q4: OR: 2.68, CI: 1.96–3.68, P trend < 0.001), linear (P nonlinearity = 0.108). And subgroup analysis yielded results consistent primary findings. Conclusion This revealed China, individuals, elevated associated risk, suggesting is promising target prevention treatment.

Language: Английский

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Joint Association of Remnant Cholesterol and Body Mass Index with Hypertension: A National Cohort Study in Chinese Adults.

PubMed, Journal Year: 2025, Volume and Issue: 18, P. 1813 - 1825

Published: Jan. 1, 2025

Hypertension, a major global health concern, is closely associated with obesity and lipid abnormalities. Remnant cholesterol (RC), triglyceride-rich lipoprotein component, has been linked to cardiovascular diseases, but its joint impact body mass index (BMI) on hypertension risk remains unclear. We analyzed data from 3805 participants (mean age: 57 years; 44.3% male) in the China Health Retirement Longitudinal Study (CHARLS) 2011-2020. Inclusion criteria were adults aged over 45 years complete blood lipids BMI. Participants baseline or missing covariate excluded. Cox proportional hazard models assessed associations, while mediation analysis explored RC's role BMI-hypertension linkage. Over 9-year follow-up, 590 developed hypertension. Obesity (BMI ≥28.0 kg/m²) high RC levels independently (HR: 2.18; 95% CI: 1.48-3.21 for highest tertile). mediated 7.07% of BMI's effect hypertension, BMI 29.3% effect. This study highlights intertwined roles development. Targeting both factors may enhance prevention strategies.

Language: Английский

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The association between remnant cholesterol and bone mineral density in US adults: the National Health and Nutrition Examination Survey (NHANES) 2013–2018

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 18, 2024

Abstract Background Previous evidence showed a possible link of dyslipidemia with bone health. Nevertheless, the correlation remnant cholesterol (RC) mineral density (BMD) has yet to be well investigated. This study investigated association RC total spine BMD in general Americans. Methods explored relationship subjects aged ≥ 20 years from National Health and Nutrition Examination Survey (NHANES) 2013–2018. After adjusting for covariates, multivariate linear regression stratified analyses were conducted determine serum adult Restricted cubic spline (RCS) was applied examine nonlinear BMD. Results included 3815 individuals old, 1905 (49.93%) whom men 1910 (50.07%) women. all results negative (β= -0.024, 95% CI: -0.039, -0.010). The interaction tests age, sex, race, BMI no statistically significant effects on association. RCS also indicated (nonlinear P = 0.068, overall < 0.001). Moreover, had stronger effect than (TC), low-density lipoprotein (LDL-C), high-density (HDL-C). Conclusions found that negatively related U.S. adults. These findings emphasized important role health American

Language: Английский

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Remnant Cholesterol and New-onset Atrial Fibrillation: The Atherosclerosis Risk in Communities Study

Heart Rhythm, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Is remnant cholesterol a new therapeutic target for preventing hypertension?

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(5), P. 1227 - 1228

Published: March 5, 2024

Language: Английский

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Impact of hypercholesterolemic diet on the Ca-regulating hormones and some minerals in male rats

Journal of Kerbala for Agricultural Sciences, Journal Year: 2024, Volume and Issue: 11(2), P. 62 - 75

Published: June 9, 2024

AbstractCholesterol is a fatty substance essential for the body. However, excessive amounts can lead to health problems. The study's objective was investigate potential effects of diet high in cholesterol on hormonal regulation calcium metabolism and balance minerals Twenty male rats aged (1.5-2 ) months were divided as follows, 2 groups : (10) fed normal diet, diet(2%) 8 weeks HCD group. Blood samples collected after end experiment physiological biomarker parameters calculation, well lipid profile, minerals, hormones, antioxidants, (8 weeks). results showed significant elevation serum profile (TG, TC, LDL) decreased (HDL), an Malondialdehyde (MDA) increase levels. Calcitonin levels, parathyroid hormone, Vit.D levels decrease Glutathione (GSH) group compared control study concludes that hypercholesterolemic Dysregulation Ca-regulating hormone (PTH), Calcitonin, which may disrupt delicate This could result increased bone resorption, altered absorption excretion, imbalances other involved overall processes.

Language: Английский

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The Impact of Remnant Cholesterol on Cardiovascular Fitness in Young Adults: Insights from NHANES

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Background Remnant cholesterol (RC) is associated with the occurrence, progression, and prognosis of cardiovascular diseases (CVD) in elderly populations. However, relation between RC fitness (CVF) young populations remains inconclusive. This research aimed to analyze correlation levels impairment among United States youth individuals. Method A cross-sectional analysis was performed utilizing datasets from National Health Nutrition Examination Survey (NHANES) 1999–2004, including 3,097 participants who underwent CVF testing provided fasting blood sample. considered total (TC)-high-density lipoprotein (HDL-C)-high-density (LDL-C). Weighted multivariate logistic regression analyses were used assess relationship impairment. Results The revealed a significant association higher an increased risk After adjusting for confounding factors, each unit (1mmol/L) increase remnant cholesterol, impaired increases by 65%. restricted cubic spline (RCS) curves demonstrate linear CVF. Interaction terms showed that positive likelihood consistent across different population statuses could be applicable various demographic settings. Conclusions Elevated finding emphasized importance monitoring assessment populations, potentially guiding early prevention strategies.

Language: Английский

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Association between Remnant Cholesterol and Metabolic Syndrome among Chinese Adults: Chinese Nutrition and Health Surveillance (2015–2017)

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3275 - 3275

Published: Sept. 27, 2024

Background: Remnant cholesterol (RC) is highly associated with several chronic diseases. However, the relationship between RC and Metabolic syndrome (MetS) remains unclear. The study’s objective to illustrate of MetS. Methods: data were collected from Chinese Nutrition Health Surveillance (2015–2017), which included personal, household dietary information. A total 65,618 residents aged 20 years or older 31 provinces in mainland China this study. was calculated by equation = TC − (LDL-C + HDL-C). criteria for MetS based on 2020 Type 2 Diabetes Prevention Treatment Guidelines. Logistic regression models used analyse every component. receiver operating characteristic (ROC) curve established evaluate accuracy identifying MetS, area under (AUC) best threshold calculated. Results: weighted level 0.48 mmol/L. Participants high levels likely be elderly, have a higher prevalence (TC), triglyceride (TG), low-density lipoprotein (LDL-C), fasting blood glucose (FBG), hba1c, lower high-density (HDL-C). Sex, body mass index (BMI), education status, yearly income per capita, marital country, residence location, smoking fruit intake sleep time had statistical differences group (p < 0.05). OR gradually increased an increase quartile 0.01), quartiles (Q4) suggested highest risk. each component quartile. ROC found that identify AUC 0.71 0.52 mmol/L, respectively. Conclusions: positive association than other indexes. current study could provide new scientific evidence early prevention control

Language: Английский

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