Neurobiology of Disease,
Journal Year:
2020,
Volume and Issue:
144, P. 105028 - 105028
Published: July 28, 2020
While
glia
are
essential
for
regulating
the
homeostasis
in
normal
brain,
their
dysfunction
contributes
to
neurodegeneration
many
brain
diseases,
including
Parkinson's
disease
(PD).
Recent
studies
have
identified
that
PD-associated
genes
expressed
glial
cells
as
well
neurons
and
crucial
roles
microglia
astrocytes.
Here,
we
discuss
role
of
astrocytes
relation
PD-linked
mutations
implications
PD
pathogenesis.
A
better
understanding
astrocyte
functions
may
provide
insights
into
novel
therapeutic
approaches
PD.
Science,
Journal Year:
2019,
Volume and Issue:
365(6460)
Published: Sept. 26, 2019
We
analyzed
genetic
data
of
47,429
multiple
sclerosis
(MS)
and
68,374
control
subjects
established
a
reference
map
the
architecture
MS
that
includes
200
autosomal
susceptibility
variants
outside
major
histocompatibility
complex
(MHC),
one
chromosome
X
variant,
32
within
extended
MHC.
used
an
ensemble
methods
to
prioritize
551
putative
genes
implicate
innate
adaptive
pathways
distributed
across
cellular
components
immune
system.
Using
expression
profiles
from
purified
human
microglia,
we
observed
enrichment
for
in
these
brain-resident
cells,
suggesting
may
have
role
targeting
autoimmune
process
central
nervous
system,
although
is
most
likely
initially
triggered
by
perturbation
peripheral
responses.
Journal of Alzheimer s Disease,
Journal Year:
2018,
Volume and Issue:
64(s1), P. S161 - S189
Published: June 12, 2018
Background:The
Religious
Orders
Study
and
Rush
Memory
Aging
Project
are
both
ongoing
longitudinal
clinical-pathologic
cohort
studies
of
aging
Alzheimer's
disease
(AD).
Objectives:To
summarize
progress
over
the
past
five
years
its
implications
for
understanding
neurodegenerative
diseases
.
Methods:Participants
in
older
adults
who
enroll
without
dementia
agree
to
detailed
clinical
evaluations
organ
donation.
The
last
review
summarized
findings
through
end
2011.
Here
we
study
discuss
new
directions
how
these
can
inform
on
AD
future.
Results:We
1)
relation
neurobiology
AD;
2)
neurobiologic
pathways
linking
risk
factors
3)
non-cognitive
phenotypes
including
motor
function
decision
making;
4)
development
a
novel
drug
discovery
platform.
Conclusion:Complexity
at
multiple
levels
needs
be
understood
overcome
develop
effective
treatments
preventions
cognitive
decline
dementia.
Molecular Neurodegeneration,
Journal Year:
2020,
Volume and Issue:
15(1)
Published: July 16, 2020
Abstract
Alzheimer’s
disease
(AD)
is
the
most
common
neurodegenerative
disorder
seen
in
age-dependent
dementia.
There
currently
no
effective
treatment
for
AD,
which
may
be
attributed
part
to
lack
of
a
clear
underlying
mechanism.
Studies
within
last
few
decades
provide
growing
evidence
central
role
amyloid
β
(Aβ)
and
tau,
as
well
glial
contributions
various
molecular
cellular
pathways
AD
pathogenesis.
Herein,
we
review
recent
progress
with
respect
Aβ-
tau-associated
mechanisms,
discuss
dysfunction
emphasis
on
neuronal
receptors
that
mediate
Aβ-induced
toxicity.
We
also
other
critical
factors
affect
pathogenesis,
including
genetics,
aging,
variables
related
environment,
lifestyle
habits,
describe
potential
apolipoprotein
E
(APOE),
viral
bacterial
infection,
sleep,
microbiota.
Although
have
gained
much
towards
understanding
aspects
this
devastating
disorder,
greater
commitment
research
mechanism,
diagnostics
will
needed
future
research.
