Microglia and astrocyte dysfunction in parkinson's disease DOI Creative Commons
Tae‐In Kam, Jared T. Hinkle, Ted M. Dawson

et al.

Neurobiology of Disease, Journal Year: 2020, Volume and Issue: 144, P. 105028 - 105028

Published: July 28, 2020

While glia are essential for regulating the homeostasis in normal brain, their dysfunction contributes to neurodegeneration many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes expressed glial cells as well neurons and crucial roles microglia astrocytes. Here, we discuss role of astrocytes relation PD-linked mutations implications PD pathogenesis. A better understanding astrocyte functions may provide insights into novel therapeutic approaches PD.

Language: Английский

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing DOI
Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims

et al.

Nature Genetics, Journal Year: 2019, Volume and Issue: 51(3), P. 414 - 430

Published: Feb. 28, 2019

Language: Английский

Citations

2513

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? DOI

Fangda Leng,

Paul Edison

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 17(3), P. 157 - 172

Published: Dec. 14, 2020

Language: Английский

Citations

2152

Single-cell transcriptomic analysis of Alzheimer’s disease DOI
Hansruedi Mathys, José Dávila-Velderrain, Zhuyu Peng

et al.

Nature, Journal Year: 2019, Volume and Issue: 570(7761), P. 332 - 337

Published: May 1, 2019

Language: Английский

Citations

2069

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility DOI
Nikolaos A. Patsopoulos, Sergio E. Baranzini, Adam Santaniello

et al.

Science, Journal Year: 2019, Volume and Issue: 365(6460)

Published: Sept. 26, 2019

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects established a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 within extended MHC. used an ensemble methods to prioritize 551 putative genes implicate innate adaptive pathways distributed across cellular components immune system. Using expression profiles from purified human microglia, we observed enrichment for in these brain-resident cells, suggesting may have role targeting autoimmune process central nervous system, although is most likely initially triggered by perturbation peripheral responses.

Language: Английский

Citations

1096

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration DOI Creative Commons
Aleksandra Deczkowska, Hadas Keren‐Shaul, Assaf Weiner

et al.

Cell, Journal Year: 2018, Volume and Issue: 173(5), P. 1073 - 1081

Published: May 1, 2018

Language: Английский

Citations

1048

Religious Orders Study and Rush Memory and Aging Project DOI
David A. Bennett, Aron S. Buchman, Patricia A. Boyle

et al.

Journal of Alzheimer s Disease, Journal Year: 2018, Volume and Issue: 64(s1), P. S161 - S189

Published: June 12, 2018

Background:The Religious Orders Study and Rush Memory Aging Project are both ongoing longitudinal clinical-pathologic cohort studies of aging Alzheimer's disease (AD). Objectives:To summarize progress over the past five years its implications for understanding neurodegenerative diseases . Methods:Participants in older adults who enroll without dementia agree to detailed clinical evaluations organ donation. The last review summarized findings through end 2011. Here we study discuss new directions how these can inform on AD future. Results:We 1) relation neurobiology AD; 2) neurobiologic pathways linking risk factors 3) non-cognitive phenotypes including motor function decision making; 4) development a novel drug discovery platform. Conclusion:Complexity at multiple levels needs be understood overcome develop effective treatments preventions cognitive decline dementia.

Language: Английский

Citations

1039

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease DOI
Yingyue Zhou, Wilbur M. Song,

Prabhakar S. Andhey

et al.

Nature Medicine, Journal Year: 2020, Volume and Issue: 26(1), P. 131 - 142

Published: Jan. 1, 2020

Language: Английский

Citations

916

Microglial signatures and their role in health and disease DOI
Oleg Butovsky, Howard L. Weiner

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(10), P. 622 - 635

Published: Sept. 11, 2018

Language: Английский

Citations

783

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease DOI
Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage

et al.

Nature Genetics, Journal Year: 2021, Volume and Issue: 53(9), P. 1276 - 1282

Published: Sept. 1, 2021

Language: Английский

Citations

734

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease DOI Creative Commons
Tiantian Guo, Denghong Zhang,

Yuzhe Zeng

et al.

Molecular Neurodegeneration, Journal Year: 2020, Volume and Issue: 15(1)

Published: July 16, 2020

Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There currently no effective treatment for AD, which may be attributed part to lack of a clear underlying mechanism. Studies within last few decades provide growing evidence central role amyloid β (Aβ) and tau, as well glial contributions various molecular cellular pathways AD pathogenesis. Herein, we review recent progress with respect Aβ- tau-associated mechanisms, discuss dysfunction emphasis on neuronal receptors that mediate Aβ-induced toxicity. We also other critical factors affect pathogenesis, including genetics, aging, variables related environment, lifestyle habits, describe potential apolipoprotein E (APOE), viral bacterial infection, sleep, microbiota. Although have gained much towards understanding aspects this devastating disorder, greater commitment research mechanism, diagnostics will needed future research.

Language: Английский

Citations

723