Electrical Stimulation of Neurons with Quantum Dots via Near-Infrared Light DOI Creative Commons
Onuralp Karatum, Hümeyra Nur Kaleli, Guncem Ozgun Eren

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 8233 - 8243

Published: May 2, 2022

Photovoltaic biointerfaces offer wireless and battery-free bioelectronic medicine via photomodulation of neurons. Near-infrared (NIR) light enables communication with neurons inside the deep tissue application high photon flux within ocular safety limit exposure. For that, nonsilicon are highly demanded for thin flexible operation. Here, we devised a quantum dot (QD)-based photovoltaic biointerface that stimulates cells spectral transparency window by using NIR (λ = 780 nm). Integration an ultrathin QD layer 25 nm into multilayered architecture transduction to safe capacitive ionic currents leads reproducible action potentials on primary hippocampal success rates. The exhibit low in vitro toxicity robust photoelectrical performance under different stability tests. Our findings show colloidal dots can be used brain, heart, retina.

Language: Английский

Organic Bioelectronics: From Functional Materials to Next‐Generation Devices and Power Sources DOI
David Ohayon, Sahika Inal

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Conjugated polymers (CPs) possess a unique set of features setting them apart from other materials. These properties make ideal when interfacing the biological world electronically. Their mixed electronic and ionic conductivity can be used to detect weak signals, deliver charged bioactive molecules, mechanically or electrically stimulate tissues. CPs functionalized with various (bio)chemical moieties blend functional materials, aim modulating responses endow specificity toward analytes interest. They absorb photons generate charges that are then cells produce fuels. also have catalytic allowing harvest ambient energy and, along their high capacitances, promising materials for next‐generation power sources integrated bioelectronic devices. In this perspective, an overview key examination operational mechanism devices leverage these specific applications in bioelectronics is provided. addition discussing chemical structure–functionality relationships applied at interface, development new chemistries form factors would bring forth sensors, actuators, sources, hence, advances field organic described.

Language: Английский

Citations

142
Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor DOI
Malin Silverå Ejneby, Marie Jakešová, José Javier Ferrero

et al.

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 6(6), P. 741 - 753

Published: Dec. 16, 2021

Language: Английский

Citations

107
In Vivo Organic Bioelectronics for Neuromodulation DOI Creative Commons
Magnus Berggren, Eric Daniel Głowacki, Daniel T. Simon

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(4), P. 4826 - 4846

Published: Jan. 20, 2022

The nervous system poses a grand challenge for integration with modern electronics and the subsequent advances in neurobiology, neuroprosthetics, therapy which would become possible upon such integration. Due to its extreme complexity, multifaceted signaling pathways, ∼1 kHz operating frequency, complementary metal oxide semiconductor (CMOS) based appear be only technology platform at hand However, conventional CMOS-based rely exclusively on electronic therefore require an additional translate signals into language of neurobiology. Organic are just platform, capable converting addressing variety matching endogenous while simultaneously possessing favorable material similarities tissue. In this review, we introduce organic platforms modalities specifically designed role as "translator", focusing especially recent implementation

Language: Английский

Citations

78
Monolithic silicon for high spatiotemporal translational photostimulation DOI
Pengju Li, Jing Zhang, Hidenori Hayashi

et al.

Nature, Journal Year: 2024, Volume and Issue: 626(8001), P. 990 - 998

Published: Feb. 21, 2024

Language: Английский

Citations

42
From flexible electronics technology in the era of IoT and artificial intelligence toward future implanted body sensor networks DOI Creative Commons
Sanghoon Lee, Qiongfeng Shi, Chengkuo Lee

et al.

APL Materials, Journal Year: 2019, Volume and Issue: 7(3)

Published: Feb. 6, 2019

Flexible electronics technology dramatically changes the capability of sensors, which allows us to detect human biological signals not only on skin but also inside body. Wearable sensors that stick surface can various biomechanical movements, signals, and byproducts such as useful elements from sweat body temperature. On other hand, implantable directly or indirectly contact with components body, tissue, organs, muscles, support treat bodily functions problems. With development these advanced we live together a huge number in future. Toward sensor networks be fully implanted future, sustainable energy sources operation well materials enable long-term use remain challenges. In this review, first summarize state-of-the-art terms flexible wearable platforms. Additionally, review recent research trends harvesters mechanical thermal conversion into electricity for sensors. Furthermore, cover studies aspect Finally, discuss future direction may

Language: Английский

Citations

141
Recent Progress in Wireless Sensors for Wearable Electronics DOI Creative Commons
Young‐Geun Park, Sang-Il Lee, Jang‐Ung Park

et al.

Sensors, Journal Year: 2019, Volume and Issue: 19(20), P. 4353 - 4353

Published: Oct. 9, 2019

The development of wearable electronics has emphasized user-comfort, convenience, security, and improved medical functionality. Several previous research studies transformed various types sensors into a form to more closely monitor body signals enable real-time, continuous sensing. In order realize these sensing platforms, it is essential integrate wireless power supplies data communication systems with the sensors. This review article discusses recent progress in technologies Also, state-of-the-art related application sensor functionality discussed, including electronic skin, smart contact lenses, neural interfaces, retinal prostheses. Current challenges prospects are discussed.

Language: Английский

Citations

125
Development of neural interfaces and energy harvesters towards self-powered implantable systems for healthcare monitoring and rehabilitation purposes DOI
Jiahui Wang, Tianyiyi He, Chengkuo Lee

et al.

Nano Energy, Journal Year: 2019, Volume and Issue: 65, P. 104039 - 104039

Published: Aug. 19, 2019

Language: Английский

Citations

119
Optoelectronic control of single cells using organic photocapacitors DOI Creative Commons
Marie Jakešová, Malin Silverå Ejneby, Vedran Đerek

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(4)

Published: April 5, 2019

Optical control of the electrophysiology single cells can be a powerful tool for biomedical research and technology. Here, we report organic electrolytic photocapacitors (OEPCs), devices that function as extracellular capacitive electrodes stimulating cells. OEPCs consist transparent conductor layers covered with donor-acceptor bilayer photoconductors. This device produces an open-circuit voltage in physiological solution 330 mV upon illumination using light tissue transparency window 630 to 660 nm. We have performed electrophysiological recordings on Xenopus laevis oocytes, finding rapid (time constants, 50 μs 5 ms) photoinduced transient changes range 20 110 mV. measure opening potassium channels, conclusively proving OEPC effectively depolarizes cell membrane. Our results demonstrate versatile nongenetic technique optical manipulation currently represents one simplest most stable efficient stimulation solutions.

Language: Английский

Citations

107
Conformable Hybrid Systems for Implantable Bioelectronic Interfaces DOI Creative Commons
Florian Fallegger, Giuseppe Schiavone, Stéphanie P. Lacour

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(15)

Published: Oct. 14, 2019

Abstract Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, assist in reversing conditions deafness, blindness, paralysis. Combining reduced invasiveness with advanced electronic functions, hybrid have evolved tremendously last decade, pushed by progress materials science, micro‐ nanofabrication, system assembly packaging, biomedical engineering. Hybrid integration refers here to a technological approach embed within mechanically compliant carrier substrates components circuits prepared traditional materials. This combination leverages mechanical performance polymer device materials, respectively, offers many opportunities for man‐made communicate body unmet precision. However, trade‐offs between selection, manufacturing processes, resolution, electrical function, integrity, biointegration, reliability should be considered. Herein, prominent trends conformable analyzed key design, validation principles outlined together remaining challenges produce reliable conformable, systems.

Language: Английский

Citations

93
Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas DOI Creative Commons
Naïg Aurélia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

et al.

Communications Materials, Journal Year: 2021, Volume and Issue: 2(1)

Published: March 5, 2021

Abstract Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade clinical trials highlighted quantitative limitations hampering possibility reaching this goal. A key challenge retinal stimulation is to independently activate neurons over large portion subject’s visual field. Reaching such goal would significantly improve perception accuracy implants’ users, along with their spatial cognition, attention, ambient mapping and interaction environment. Here we show wide-field, high-density high-resolution photovoltaic epiretinal prosthesis for artificial (POLYRETINA). The embeds 10,498 physically functionally independent pixels, allowing wide coverage stimulation. Single-pixel illumination reproducibly induced network-mediated responses from ganglion cells at safe irradiance levels. Furthermore, POLYRETINA allowed response discrimination high resolution equivalent pixel pitch (120 µm) thanks mechanism. This approach could allow mid-peripheral patients retinitis pigmentosa.

Language: Английский

Citations

87