Biomimetic Hybrid Nanozymes with Self-Supplied H⁺ and Accelerated O₂ Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

Nano Letters, Journal Year: 2019, Volume and Issue: 19(7), P. 4334 - 4342

Published: June 10, 2019

Nanozymes as artificial enzymes that mimicked natural enzyme-like activities have received great attention in cancer diagnosis and therapy. Biomimetic nanozymes require more consideration regarding complicated tumor microenvironments to mimic biological enzymes, thus achieving superior nanozyme activity vivo. Here we report a biomimetic hybrid (named rMGB) which integrates enzyme glucose oxidase (GOx) with manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic of MnO2 GOx. Under hypoxia environment, observed could react endogenous H2O2 produce O2 enhancing catalytic efficiency GOx starvation Meanwhile, confirmed oxidation generated gluconic acid further improved subsequently. The biochemical reaction cycle, consisting MnO2, O2, GOx, H+, was triggered microenvironment accelerated each other so achieve self-supplied H+ accelerate generation, therapy, alleviating accelerating reactive oxygen species generation photodynamic This would facilitate development treatment.

Language: Английский

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Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 142(3), P. 1636 - 1644

Published: Dec. 27, 2019

Recent advances in nanomedicine have facilitated the development of potent nanomaterials with intrinsic enzyme-like activities (nanozymes) for cancer therapy. However, it remains a great challenge to fabricate smart nanozymes that precisely perform enzymatic activity tumor microenvironment without inducing off-target toxicity surrounding normal tissues. Herein, we report on designed fabrication biodegradation-medicated activity-tunable molybdenum oxide nanourchins (MoO3-x NUs), which selectively therapeutic via cascade catalytic reactions, while keeping tissues unharmed due their responsive biodegradation physiological environment. Specifically, MoO3-x NUs first induce catalase (CAT)-like reactivity decompose hydrogen peroxide (H2O2) microenvironment, producing considerable amount O2 subsequent oxidase (OXD)-like NUs; substantial cytotoxic superoxide radical (·O2-) is thus generated cell apoptosis. Interestingly, once exposed neutral blood or tissues, rapidly lose pH-responsive and are excreted urine, ultimately ensuring safety. The current study demonstrates proof concept vivo tumor-specific therapy minimal toxicity.

Language: Английский

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Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow

Biomaterials, Journal Year: 2019, Volume and Issue: 206, P. 101 - 114

Published: March 16, 2019

Language: Английский

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An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(13), P. 5108 - 5115

Published: Jan. 21, 2020

Abstract Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely the specificity low activity exploited nanozymes. Herein, an enzyme‐mimicking single‐atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co‐porphyrin centers, which can rapidly obliterate alleviate sepsis. Co/PMCS O 2 .− H mimicking superoxide dismutase, catalase, glutathione peroxidase, while removing . OH via oxidative‐reduction cycle, markedly higher than It also scavenge NO through formation a nitrosyl–metal complex. Eventually, it reduce proinflammatory cytokine levels, protect organs from damage, confer distinct survival advantage infected sepsis mice.

Language: Английский

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Manganese‐Dioxide‐Coating‐Instructed Plasmonic Modulation of Gold Nanorods for Activatable Duplex‐Imaging‐Guided NIR‐II Photothermal‐Chemodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(13)

Published: March 1, 2021

Abstract Nanotheranostic agents of gold nanomaterials in the second near‐infrared (NIR‐II) window have attracted significant attention cancer management, owing to reduced background signal and deeper penetration depth tissues. However, it is still challenging modulate localized surface plasmon resonance (LSPR) from first (NIR‐I) NIR‐II region. Herein, a plasmonic modulation strategy nanorods (GNRs) through manganese dioxide coating developed for photoacoustic/magnetic (MR) duplex‐imaging‐guided photothermal chemodynamic therapy. GNRs are coated with silica (SiO 2 ) then covered magnesium (MnO obtain final product GNR@SiO @MnO (denoted as GSM). The LSPR peak could be tuned by adjusting thickness MnO layer. Theoretical simulations reveal that this mainly due change refraction index around after Additionally, layer demonstrated degrade into Mn 2+ ions response peroxide acidic protons tumor microenvironment, which allows MR imaging This can adapted other metal construction new class nanotheranostics.

Language: Английский

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