Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

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Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(35), P. 6939 - 6957

Published: Jan. 1, 2021

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well proposes the current challenges prospects in development nanozymes.

Language: Английский

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Boron-doped Fe-N-C single-atom nanozymes specifically boost peroxidase-like activity

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100971 - 100971

Published: Sept. 17, 2020

Language: Английский

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Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Language: Английский

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Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(6), P. 617 - 627

Published: March 27, 2023

Language: Английский

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Atomic engineering of single-atom nanozymes for enzyme-like catalysis

Chemical Science, Journal Year: 2020, Volume and Issue: 11(36), P. 9741 - 9756

Published: Jan. 1, 2020

Single-atom nanozymes with definite active centers, high catalytic activities and enzyme-like selectivities promote the nanozyme research entering a new period of atomic level.

Language: Английский

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Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(6), P. 3001 - 3007

Published: Oct. 22, 2020

Abstract Nanomaterials with enzyme‐mimicking activity (nanozymes) show potential for therapeutic interventions. However, it remains a formidable challenge to selectively kill tumor cells through enzymatic reactions, while leaving normal unharmed. Herein, we present new strategy based on single‐site cascade reaction tumor‐specific therapy that avoids off‐target toxicity tissues. A copper hexacyanoferrate (Cu‐HCF) nanozyme active exhibited within the microenvironment: Tumor‐specific glutathione oxidase by Cu‐HCF nanozymes (SSNEs) led depletion of intracellular and conversion Cu II species into I subsequent amplified peroxidase Fenton‐type Harber–Weiss reaction. In this way, abundant highly toxic hydroxyl radicals were generated cell apoptosis. The results SSNEs could amplify tumor‐killing efficacy reactive oxygen suppress growth in vivo.

Language: Английский

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Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2005 - 2037

Published: Feb. 10, 2021

Single-atom catalysts (SACs) featuring the complete atomic utilization of metal, high-efficient catalytic activity, superior selectivity, and excellent stability have been emerged as a frontier in field. Recently, increasing interests drawn to apply SACs biomedical fields for enzyme-mimic catalysis disease therapy. To fulfill demand precision personalized medicine, precisely engineering structure active site toward levels is trend nanomedicines, promoting evolution metal-based nanomaterials, particularly biocatalytic from nanoparticles clusters now SACs. This review outlines syntheses, characterizations, mechanisms metal SACs, with focus on their applications including biosensing, antibacterial therapy, cancer well an emphasis vivo biological safeties. Challenges future perspectives are ultimately prospected diverse applications.

Language: Английский

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Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 7, 2021

Emerging artificial enzymes with reprogrammed and augmented catalytic activity substrate selectivity have long been pursued sustained efforts. The majority of current candidates rely on noble metals or transition metal oxides rather poor compared natural molecules. To tackle this limitation, we strategically designed a novel enzyme based structurally well-defined Au25 cluster, namely clusterzyme, which is endowed intrinsic high driven by single-atom substitutions modulated bond lengths. 3-mercaptopropionic acid (MPA)-stabilized Au24Cu1 Au24Cd1 clusterzymes exhibit 137 160 times higher antioxidant capacities than the trolox, respectively. Meanwhile, each demonstrate preferential enzyme-mimicking activities compelling selectivity: exhibits superior glutathione peroxidase-like (GPx-like) activity; shows distinct advantage towards catalase-like (CAT-like) its Cu single active site; preferably acts as superoxide dismutase-like (SOD-like) via Cd site. This unique diversified landscape manifests distinctive reactions against inflammation in brain. behaves an endogenous multi-enzyme mimic that directly decreases peroxide injured brain reactions, while Au24Cd1, catalyzes nitrogenous signal molecules preference, significantly factors such IL-1\b{eta}, IL-6, TNF{\alpha}, indicative important role mitigating neuroinflammation.

Language: Английский

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

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