Small vessel disease: mechanisms and clinical implications

The Lancet Neurology, Journal Year: 2019, Volume and Issue: 18(7), P. 684 - 696

Published: May 13, 2019

Language: Английский

---

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Science, Journal Year: 2019, Volume and Issue: 366(6465), P. 628 - 631

Published: Oct. 31, 2019

Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related not known. We used accelerated neuroimaging measure physiological dynamics human discovered a coherent pattern oscillating electrophysiological, hemodynamic, CSF that appears during non-rapid eye movement sleep. Neural slow followed by hemodynamic oscillations, which turn coupled flow. These results demonstrate sleeping exhibits flow on macroscopic scale, interlinked with rhythms.

Language: Английский

---

Glymphatic failure as a final common pathway to dementia

Science, Journal Year: 2020, Volume and Issue: 370(6512), P. 50 - 56

Published: Oct. 2, 2020

Sleep is evolutionarily conserved across all species, and impaired sleep a common trait of the diseased brain. quality decreases as we age, disruption regular architecture frequent antecedent to onset dementia in neurodegenerative diseases. The glymphatic system, which clears brain protein waste products, mostly active during sleep. Yet system degrades with suggesting causal relationship between disturbance symptomatic progression dementias. ties that bind sleep, aging, clearance, aggregation have shed new light on pathogenesis broad range diseases, for failure may constitute therapeutically targetable final pathway.

Language: Английский

---

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 16(1), P. 30 - 42

Published: Dec. 11, 2019

Language: Английский

---

Perivascular spaces in the brain: anatomy, physiology and pathology

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 16(3), P. 137 - 153

Published: Feb. 24, 2020

Language: Английский

---

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Dec. 18, 2018

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx cerebrospinal fluid (CSF) depends upon expression and perivascular localization astroglial water channel aquaporin-4 (AQP4). Prompted by recent failure find an effect Aqp4 knock-out (KO) on CSF interstitial (ISF) tracer transport, five groups re-examined importance AQP4 in transport. We concur that influx higher wild-type mice than four different KO lines one line lacks (Snta1 KO). Meta-analysis all studies demonstrated significant decrease transport rats compared controls. Meta-regression indicated anesthesia, age, delivery explain opposing results. also report intrastriatal injections suppress function. This validates role shows must avoid use invasive procedures.

Language: Английский

---

Circadian control of brain glymphatic and lymphatic fluid flow

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 2, 2020

The glymphatic system is a network of perivascular spaces that promotes movement cerebrospinal fluid (CSF) into the brain and clearance metabolic waste. This transport supported by water channel aquaporin-4 (AQP4) localized to vascular endfeet astrocytes. more effective during sleep, but whether sleep timing function remains unknown. We here show influx exhibit endogenous, circadian rhythms peaking mid-rest phase mice. Drainage CSF from cisterna magna lymph nodes exhibits daily variation opposite influx, suggesting distribution throughout animal depends on time-of-day. polarization AQP4 highest rest loss eliminates day-night difference in both drainage nodes. conclude under control supports this rhythm.

Language: Английский

---

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

Science Advances, Journal Year: 2019, Volume and Issue: 5(2)

Published: Feb. 1, 2019

We show that glymphatic influx into the brain occurs in direct proportion to slow cortical activity and inversely heart rate.

Language: Английский

---

The Brain’s Glymphatic System: Current Controversies

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(7), P. 458 - 466

Published: May 15, 2020

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within central nervous system (CNS). Imaging studies, as well manipulations transport, point to a key role glymphatic-lymphatic clearance amyloid-β and other proteins. As such, represents new target combating neurodegenerative diseases. Not unexpectedly, introduction plumbing brain has stirred controversies. This opinion article will highlight what we know about brain's transport systems, where experimental data are lacking, still debated.

Language: Английский

---

Cerebrospinal fluid influx drives acute ischemic tissue swelling

Science, Journal Year: 2020, Volume and Issue: 367(6483)

Published: Jan. 31, 2020

Spreading edema after stroke The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste. CSF transport has also recently been shown play unexpected roles neurodegeneration sleep. Mestre et al. used multimodal vivo imaging rodents found that, stroke, an abnormally large volume rushes into the brain, causing swelling (see Perspective by Moss Williams). This influx caused constrictions arteries triggered well-known propagating chemical reaction-diffusion wave called spreading depolarization. can thus role stroke. Science , this issue p. eaax7171 ; see 1195

Language: Английский

---