Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Circulation, Journal Year: 2023, Volume and Issue: 147(8)

Published: Jan. 25, 2023

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs). Methods: through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual review published literature year before writing. 2023 is product full year’s worth effort 2022 by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional COVID-19 (coronavirus 2019) publications, as well monitoring benefits population, an enhanced focus equity across key domains. Results: Each chapters focuses different topic statistics. Conclusions: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

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Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Circulation, Journal Year: 2022, Volume and Issue: 145(8)

Published: Jan. 26, 2022

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).

Language: Английский

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2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Circulation, Journal Year: 2024, Volume and Issue: 149(8)

Published: Jan. 24, 2024

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, obesity) factors (cholesterol, blood pressure, glucose control, metabolic syndrome) that contribute health. AHA Disease Stroke Statistical Update presents latest data on a range major clinical circulatory disease conditions (including brain health, complications pregnancy, kidney congenital rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary cardiomyopathy, failure, valvular venous thromboembolism, peripheral artery disease) associated outcomes quality care, procedures, economic costs). METHODS: AHA, through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States globally provide current information available annual review published literature year before writing. 2024 is product full year’s worth effort 2023 by dedicated volunteer clinicians scientists, committed government professionals, staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional global data, as well monitoring benefits population, an enhanced focus equity across key domains. RESULTS: Each chapters focuses different topic statistics. CONCLUSIONS: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 30, 2020

Abstract Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank GWA consortia, we found that a one standard deviation increment average acceleration was (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) (OR: 0.66, CI: 0.48 0.90, 0.01). We similar magnitude inverse for estrogen positive (ER +ve ) colon cancer. Our results support potentially relationship between higher physical levels Based on data, promotion probably an effective strategy primary prevention commonly diagnosed cancers.

Language: Английский

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Virus exposure and neurodegenerative disease risk across national biobanks

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1086 - 1093.e2

Published: Jan. 19, 2023

Language: Английский

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Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 13, 2022

Abstract Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (PA) increased leisure sedentary behaviors (LSB). Given that both PA LSB have been established as major influencing factors obesity, diabetes cardiometabolic syndrome, whether PA/LSB in turn affects susceptibility COVID-19 by disrupting metabolic homeostasis remains be explored. In this study, we aimed systematically evaluate causal relationship between susceptibility, hospitalization severity using a Mendelian randomization study. Methods Data were obtained from large-scale dataset (N = 377,000), 422,218) Host Genetics Initiative 2,586,691). effects estimated with inverse variance weighted, MR-Egger, weighted median MR-PRESSO. Sensitivity analyses implemented Cochran’s Q test, MR-Egger intercept MR-PRESSO, leave-one-out analysis funnel plot. Risk factor further conducted investigate potential mediators. Results Genetically predicted accelerometer-assessed risk (OR 0.93, 95% CI 0.88–0.97; P 0.002), while television watching significantly 1.55, 1.29–1.88; 4.68 × 10 –6 ) 1.85, 1.33–2.56; 0.0002) after Bonferroni correction. No self-reported moderate vigorous (MVPA), accelerometer fraction accelerations > 425 milligravities, computer use or driving on progression observed. indicated above associations might mediated several factors, including smoking, high body mass index, elevated serum triglyceride levels, insulin resistance occurrence type 2 diabetes. Conclusion Our findings supported effect reduced well severity, which was potentially obesity diabetes-related phenotypes. Particular attention should given reducing encouraging proper exercise during quarantine COVID-19.

Language: Английский

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Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(6), P. 435 - 453

Published: March 11, 2021

Language: Английский

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Genetics of circadian rhythms and sleep in human health and disease

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 24(1), P. 4 - 20

Published: Aug. 26, 2022

Language: Английский

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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Nature Genetics, Journal Year: 2022, Volume and Issue: 54(9), P. 1332 - 1344

Published: Sept. 1, 2022

Abstract Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association yields 99 loci associate with self-reported moderate-to-vigorous intensity during leisure time (MVPA), screen (LST) and/or at work. Loci associated LST enriched genes whose expression skeletal muscle altered by resistance training. A missense variant ACTN3 makes alpha-actinin-3 filaments more flexible, resulting lower maximal force isolated type II fibers, possibly protection exercise-induced damage. Finally, Mendelian randomization analyses show beneficial effects higher MVPA on several risk factors diseases mediated or confounded body mass index (BMI). Our results provide insights into its role disease prevention.

Language: Английский

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Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study

PLoS Medicine, Journal Year: 2021, Volume and Issue: 18(1), P. e1003487 - e1003487

Published: Jan. 12, 2021

Background Higher levels of physical activity (PA) are associated with a lower risk cardiovascular disease (CVD). However, uncertainty exists on whether the inverse relationship between PA and incidence CVD is greater at highest PA. Past studies have mostly relied self-reported evidence from questionnaire-based PA, which crude cannot capture all undertaken. We investigated association accelerometer-measured moderate, vigorous, total incident CVD. Methods findings obtained moderate-intensity vigorous-intensity activities volume over 7-day period in 2013–2015, for 90,211 participants without prior or concurrent UK Biobank cohort. Participants lowest category smoked more, had higher body mass index C-reactive protein, were diagnosed hypertension. was 3,617 cases during 440,004 person-years follow-up (median (interquartile range [IQR]): 5.2 (1.2) years) using Cox regression models. found linear dose–response measured as moderate-intensity, vigorous-intensity, volume, Hazard ratios (HRs) 95% confidence intervals increasing quarters distribution relative to fourth PA: 0.71 (0.65, 0.77), 0.59 (0.54, 0.65), 0.46 (0.41, 0.51); 0.70 (0.64, 0.54 (0.49,0.59), 0.41 (0.37,0.46); 0.73 (0.67, 0.79), 0.63 (0.57, 0.69), 0.47 (0.43, 0.52). took account potential confounders but unmeasured confounding remains possibility, while removal early deaths did not affect estimated HRs, we completely dismiss likelihood that reverse causality has contributed findings. Another possible limitation this work quantification intensity-levels based methods validated relatively small studies. Conclusions In study, no threshold objectively Our suggest only CVD, greatest benefit seen those who active level.

Language: Английский

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