Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(23)
Published: June 16, 2022
In
the
field
of
nanomedicine,
there
is
a
tendency
matching
designed
nanomaterials
with
suitable
type
orthotopic
cancer
model,
not
just
casual
subcutaneous
one.
Under
this
condition,
knowing
specific
features
chosen
model
priority,
then
introducing
proper
therapy
strategy
using
nanomaterials.
Here,
Fenton
chemistry
combined
zinc
peroxide
nanoparticles
in
treatment
liver
which
has
"chemical
factory"
including
that
main
place
for
iron
storage,
metabolism,
and
also
metabolic
sites
majority
ingested
substances,
guaranteeing
customized
enhanced
chemodynamic
normal
cells
protection
as
well.
The
good
results
vitro
vivo
can
set
an
inspiring
example
exploring
utilizing
corresponding
models,
ensuring
well-fitness
disease
satisfactory
therapeutic
effect.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 10, 2021
The
Myc
proto-oncogene
family
consists
of
three
members,
C-MYC,
MYCN,
and
MYCL,
which
encodes
the
transcription
factor
c-Myc
(hereafter
Myc),
N-Myc,
L-Myc,
respectively.
protein
orchestrates
diverse
physiological
processes,
including
cell
proliferation,
differentiation,
survival,
apoptosis.
modulates
about
15%
global
transcriptome,
its
deregulation
rewires
cellular
signaling
modules
inside
tumor
cells,
thereby
acquiring
selective
advantages.
occurs
in
>70%
human
cancers,
is
related
to
poor
prognosis;
hence,
hyperactivated
oncoprotein
has
been
proposed
as
an
ideal
drug
target
for
decades.
Nevertheless,
no
specific
currently
available
directly
Myc,
mainly
because
"undruggable"
properties:
lack
enzymatic
pocket
conventional
small
molecules
bind;
inaccessibility
antibody
due
predominant
nucleus
localization
Myc.
Although
topic
targeting
actively
reviewed
past
decades,
exciting
new
progresses
this
field
keep
emerging.
In
review,
after
a
comprehensive
summarization
valuable
sources
potential
druggable
targets
Myc-driven
cancer,
we
also
peer
into
promising
future
utilizing
macropinocytosis
deliver
peptides
like
Omomyc
or
agents
intracellular
compartment
cancer
treatment.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(2), P. 156 - 156
Published: Feb. 5, 2021
Inositol-requiring
enzyme
type
1
(IRE1)
is
a
serine/threonine
kinase
acting
as
one
of
three
branches
the
Unfolded
Protein
Response
(UPR)
signaling
pathway,
which
activated
upon
endoplasmic
reticulum
(ER)
stress
conditions.
It
known
to
be
capable
inducing
both
pro-survival
and
pro-apoptotic
cellular
responses,
are
strictly
related
numerous
human
pathologies.
Among
others,
IRE1
activity
has
been
confirmed
increased
in
cancer,
neurodegeneration,
inflammatory
metabolic
disorders,
associated
with
an
accumulation
misfolded
proteins
within
ER
lumen
resulting
Emerging
evidence
suggests
that
genetic
or
pharmacological
modulation
may
have
significant
impact
on
cell
viability,
thus
promising
step
forward
towards
development
novel
therapeutic
strategies.
In
this
review,
we
extensively
describe
structural
analysis
molecule,
molecular
dynamics
activation,
interconnection
between
it
other
UPR
regard
its
potential
use
target.
Detailed
knowledge
characteristics
protein
activation
allow
design
specific
RNase
modulators
act
drug
candidates.
