Macrophage polarization and its impact on idiopathic pulmonary fibrosis DOI Creative Commons

Zhouling Ge,

Yong Q. Chen,

Leikai Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Language: Английский

Hallmarks of aging: An expanding universe DOI Creative Commons
Carlos López‐Otín, Marı́a A. Blasco, Linda Partridge

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 243 - 278

Published: Jan. 1, 2023

Language: Английский

Citations

2817
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics DOI Creative Commons
Zhen Luo, Mingfu Tian, Ge Yang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 7, 2022

Abstract Molecular oxygen (O 2 ) is essential for most biological reactions in mammalian cells. When the intracellular content decreases, it called hypoxia. The process of hypoxia linked to several processes, including pathogenic microbe infection, metabolic adaptation, cancer, acute and chronic diseases, other stress responses. mechanism underlying cells respond changes mediate subsequent signal response central question during Hypoxia-inducible factors (HIFs) sense regulate expressions a series downstream genes expression, which participate multiple processes cell metabolism, growth/death, proliferation, glycolysis, immune response, tumorigenesis, metastasis. Importantly, signaling also interacts with cellular pathways, such as phosphoinositide 3-kinase (PI3K)-mammalian target rapamycin (mTOR) signaling, nuclear factor kappa-B (NF-κB) pathway, extracellular signal-regulated kinases (ERK) endoplasmic reticulum (ER) stress. This paper systematically reviews mechanisms activation, control HIF function human health diseases. In addition, therapeutic targets involved balance diseases are summarized highlighted, would provide novel strategies design development drugs.

Language: Английский

Citations

250
Reshaping endoplasmic reticulum quality control through the unfolded protein response DOI Creative Commons
R. Luke Wiseman, Jaleh S. Mesgarzadeh, Linda M. Hendershot

et al.

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(8), P. 1477 - 1491

Published: April 1, 2022

Language: Английский

Citations

233
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome DOI Creative Commons
Renjun Lv, Xueying Liu, Yue Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Abstract Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in which the airways narrow or collapse during sleep, causing obstructive apnea. The prevalence of OSAS continues to rise worldwide, particularly middle-aged and elderly individuals. mechanism upper airway incompletely understood but associated with several factors, including obesity, craniofacial changes, altered muscle function airway, pharyngeal neuropathy, fluid shifts neck. main characteristics are recurrent pauses respiration, lead intermittent hypoxia (IH) hypercapnia, accompanied by blood oxygen desaturation arousal sharply increases risk diseases. This paper first briefly describes epidemiology, incidence, pathophysiological mechanisms OSAS. Next, alterations relevant signaling pathways induced IH systematically reviewed discussed. For example, can induce gut microbiota (GM) dysbiosis, impair intestinal barrier, alter metabolites. These ultimately secondary oxidative stress, systemic inflammation, sympathetic activation. We then summarize effects on disease pathogenesis, cardiocerebrovascular disorders, neurological metabolic diseases, cancer, reproductive COVID-19. Finally, different therapeutic strategies for caused causes proposed. Multidisciplinary approaches shared decision-making necessary successful treatment future, more randomized controlled trials needed further evaluation define what treatments best specific patients.

Language: Английский

Citations

164
Melatonin Engineering M2 Macrophage‐Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy DOI Creative Commons

Ya Cui,

Shebin Hong,

Yunhui Xia

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(27)

Published: July 14, 2023

Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential component of the host immunity, macrophages are highly plastic and play crucial role in inflammatory response. An appropriate timely transition from proinflammatory (M1) to anti-inflammatory (M2) indispensable for treating periodontitis. M2 macrophage-derived exosomes (M2-exos) can actively target sites modulate immune microenvironments, M2-exos effectively treat Excessive endoplasmic reticulum stress (ER stress) unfolded protein response (UPR) destructive pathological characteristics during periodontal bone loss. Although melatonin has antioxidant effects, studies focusing on ER modulation remain limited. This study fabricates engineered loading with (Mel@M2-exos) result, drive macrophage reprogramming M1 type, which resolves inflammation accelerated healing. Melatonin released Mel@M2-exos rescues osteogenic cementogenic differentiation capacity human ligament cells (hPDLCs) reducing excessive UPR. Injectable gelatin methacryloyl (GelMA) hydrogels sustained-release accelerate regeneration rats ligation-induced Taken together, engineering promising candidates tissue regeneration.

Language: Английский

Citations

75
Reactive oxygen species and ovarian diseases: Antioxidant strategies DOI Creative Commons

Junzhi Liang,

Yingzhuo Gao,

Ziyi Feng

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102659 - 102659

Published: March 7, 2023

Reactive oxygen species (ROS) are mainly produced in mitochondria and involved various physiological activities of the ovary through signaling critical for regulating ovarian cycle. Notably, imbalance between ROS generation antioxidant defense system contributes to development diseases. These contradictory effects have implications potential strategies that aim scavenge excessive ROS. However, much remains be learned about how causes diseases application therapy Here, we review mechanisms maintenance homeostasis its associated effects. Additionally, highlighted pathological treatment.

Language: Английский

Citations

73
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications DOI Creative Commons
Xiang‐Long Chen, Anran Zhang, Kangcheng Zhao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

Citations

25
Mechanism of Decision Making between Autophagy and Apoptosis Induction upon Endoplasmic Reticulum Stress DOI Open Access
Orsolya Kapuy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4368 - 4368

Published: April 15, 2024

Dynamic regulation of the cellular proteome is mainly controlled in endoplasmic reticulum (ER). Accumulation misfolded proteins due to ER stress leads activation unfolded protein response (UPR). The primary role UPR reduce bulk damages and try drive back system former or a new homeostatic state by autophagy, while an excessive level results apoptosis. It has already been proven that proper order characteristic features both surviving self-killing mechanisms are negative positive feedback loops, respectively. suggest these loops found not only within but also between branches UPR, fine-tuning stress. In this review, we summarize recent knowledge dynamical mechanism using theoretical molecular biological techniques. addition, review pays special attention describing action controlling life-and-death decision upon Since appears diseases common worldwide, more detailed understanding behaviour medical importance.

Language: Английский

Citations

20
A multifunctional injectable hydrogel for boosted diabetic wound healing assisted by Quercetin-ZIF system DOI

Jinglei Gong,

Hao Wang,

Chaoming Xie

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153425 - 153425

Published: June 22, 2024

Language: Английский

Citations

19
The interconnective role of the UPS and autophagy in the quality control of cancer mitochondria DOI Creative Commons

Wanting Xu,

Lei Dong, Jiyan Dai

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: Jan. 12, 2025

Uncontrollable cancer cell growth is characterized by the maintenance of cellular homeostasis through continuous accumulation misfolded proteins and damaged organelles. This review delineates roles two complementary synergistic degradation systems, ubiquitin–proteasome system (UPS) autophagy-lysosome system, in organelles for intracellular recycling. We emphasize interconnected decision-making processes systems maintaining homeostasis, such as biophysical state substrates, receptor oligomerization potentials (e.g., p62), compartmentalization capacities membrane structures). Mitochondria, hubs respiration metabolism, are implicated tumorigenesis. In subsequent sections, we thoroughly examine mechanisms mitochondrial quality control (MQC) preserving human cells. Notably, explored relationships between dynamics (fusion fission) various MQC processes—including UPS, proteases, mitophagy—in context repair pathways. Finally, assessed potential targeting (including molecular chaperones, dynamics, mitophagy biogenesis) therapeutic strategies. Understanding underlying may offer novel insights future therapies. highlights UPS degrading proteins, emphasizing substrate states, oligomerization, homeostasis. Innovatively links coordination to examining interplay these pathways varying degrees damage.

Language: Английский

Citations

2