Chronic kidney disease and gut microbiota DOI Creative Commons
Siamak Amini Khiabani, Mohammad Asgharzadeh, Hossein Samadi Kafil

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18991 - e18991

Published: Aug. 1, 2023

Chronic kidney disease (CKD) refers to a range of various pathophysiological processes correlated with abnormal renal function and progressive loss in GFR. Just as dysbiosis altered pathology the gut are accompanied hypertension, which is significant CKD risk factor. Gut patients associated an elevated levels uremic toxins, turn increases progression. According research results, gut-kidney axis has role formation stones, also IgAN. A number researchers have categorized microbiota enterotypes, others, skeptical theory suggested biomarkers describe taxa that related lifestyle, nutrition, status. Metabolome-microbiome studies been used investigate interactions host-gut terms involvement metabolites these yielded promising results. The correlation between requires further multi-omic researches. Also, regard systems biology, on communication network proteins transporters such SLC ABC, can help us achieve deeper understanding gut-liver-kidney thus provide new horizons treatment patients. Probiotic-based approach reduce poisoning, accomplished by swallowing microbes those catalyze URS gut. If comprehensive carried out, we will know about probiotics impact slowing failure progression reducing inflammatory markers.

Language: Английский

Role of the gut microbiota in type 2 diabetes and related diseases DOI
Ge Yang, Jinlong Wei, Pinyi Liu

et al.

Metabolism, Journal Year: 2021, Volume and Issue: 117, P. 154712 - 154712

Published: Jan. 23, 2021

Language: Английский

Citations

295
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies DOI Creative Commons

Yiwen Li,

Yanfei Liu, Shiwei Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: April 10, 2023

Abstract Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on single vascular complication are no longer suitable for the long-term management patients with diabetes. Diabetic panvascular disease (DPD) is clinical syndrome in which vessels various sizes, including macrovessels microvessels cardiac, cerebral, renal, ophthalmic, peripheral systems diabetes, develop atherosclerosis as common pathology. Pathological manifestations DPDs usually manifest macrovascular atherosclerosis, well microvascular endothelial function impairment, basement membrane thickening, microthrombosis. Cardiac, microangiopathy coexist microangiopathy, while renal retinal predominantly microangiopathic. The following associations exist between DPDs: numerous similar molecular mechanisms, risk-predictive relationships diseases. Aggressive glycemic control combined early comprehensive intervention key prevention treatment. In addition widely recommended metformin, glucagon-like peptide-1 agonist, sodium-glucose cotransporter-2 inhibitors, latest aldose reductase peroxisome proliferator-activated receptor-γ agonizts, glucokinases mitochondrial energy modulators, etc. under active development. proposed obtain more systematic care requires center focusing This would leverage advantages cross-disciplinary approach achieve better integration pathogenesis therapeutic evidence. Such strategy confer benefits promote development DPD discipline.

Language: Английский

Citations

269
The long-term genetic stability and individual specificity of the human gut microbiome DOI Creative Commons
Lianmin Chen, Daoming Wang, Sanzhima Garmaeva

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(9), P. 2302 - 2315.e12

Published: April 1, 2021

Language: Английский

Citations

265
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome DOI Creative Commons
Ziying Zhang,

Haosheng Tang,

Peng Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)

Published: Oct. 11, 2019

Abstract The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects host pathophysiology. Remarkable progress large-scale sequencing mass spectrometry has increased our understanding influence and/or its metabolites onset progression extraintestinal cancers efficacy cancer immunotherapy. Given plasticity microbial composition function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, probiotics, as well fecal transplantation, potentially permit development novel strategies for therapy improve clinical outcomes. Herein, we summarize latest evidence involvement immunity metabolism, effects immune response, modulate microbiome, discuss ongoing studies future areas research that deserve focused efforts.

Language: Английский

Citations

209
Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus DOI Creative Commons
Zheng Zhou, Bao Sun, Dongsheng Yu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 15, 2022

Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in world. Due to rise morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, its intervention measures mainly focus on glucose control as well prevention treatment related complications. Interestingly, gut microbiota plays an important role development diseases, especially T2DM. In this review, we introduce characteristics population, animal models, diabetic addition, describe molecular mechanisms linking host T2DM, including molecules that induce dysbiosis, immune inflammatory responses, microbial metabolites involved pathogenesis. These findings suggest can treat complications by remodeling through interventions such drugs, probiotics, prebiotics, fecal transplantation (FMT) diets.

Language: Английский

Citations

196
Molecular pathways that drive diabetic kidney disease DOI Creative Commons

Samer Mohandes,

Tomohito Doke, Hailong Hu

et al.

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(4)

Published: Feb. 14, 2023

Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney (DKD) responsible for close to half all chronic cases. DKD usually develops in genetically susceptible individual as result poor metabolic (glycemic) control. Molecular genetic studies indicate the key role podocytes endothelial cells driving albuminuria early diabetes. Proximal tubule changes show strong association glomerular filtration rate. Hyperglycemia represents cellular stress by altering metabolism imposing an excess workload requiring energy oxygen proximal cells. Changes induce adaptive hypertrophy reorganization actin cytoskeleton. Later, mitochondrial defects contribute increased oxidative activation inflammatory pathways, causing progressive function decline fibrosis. Blockade renin-angiotensin system or sodium-glucose cotransporter associated protection slowing decline. Newly identified molecular pathways could provide basis development much-needed novel therapeutics.

Language: Английский

Citations

185
Proteomics and Metabolomics in Kidney Disease, including Insights into Etiology, Treatment, and Prevention DOI Open Access
Ruth F. Dubin, Eugene P. Rhee

Clinical Journal of the American Society of Nephrology, Journal Year: 2019, Volume and Issue: 15(3), P. 404 - 411

Published: Oct. 21, 2019

In this review of the application proteomics and metabolomics to kidney disease research, we key concepts, highlight illustrative examples, outline future directions. The proteome metabolome reflect influence environmental exposures in addition genetic coding. Circulating levels proteins metabolites are dynamic modifiable, thus amenable therapeutic targeting. Design analytic considerations studies should be tailored investigator’s goals. For identification clinical biomarkers, adjustment for all potential confounding variables, particularly GFR, strict significance thresholds warranted. However, approach has obscure biologic signals can overly conservative given high degree intercorrelation within metabolome. Mass spectrometry, often coupled up-front chromatographic separation techniques, is a major workhorse both metabolomics. High-throughput antibody- aptamer-based proteomic platforms have emerged as additional, powerful approaches assay proteome. As breadth coverage these methodologies continues expand, machine learning tools pathway analyses help select molecules greatest interest categorize them distinct themes. Studies date already made substantial effect, example elucidating target antigens membranous nephropathy, identifying signature urinary peptides that adds prognostic information albumin CKD, implicating circulating inflammatory mediators diabetic demonstrating role microbiome uremic milieu, highlighting bioenergetics modifiable factor AKI. Additional required replicate expand on findings independent cohorts. Further, more work needed understand longitudinal trajectory protein metabolite markers, perform transomics merged datasets, incorporate tissue–based investigation.

Language: Английский

Citations

148
Faecal metabolome and its determinants in inflammatory bowel disease DOI Creative Commons
Arnau Vich Vila, Shixian Hu, Sergio Andreu‐Sánchez

et al.

Gut, Journal Year: 2023, Volume and Issue: 72(8), P. 1472 - 1485

Published: March 23, 2023

Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory of the intestine, comprising Crohn’s and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics clinical characteristics, we aimed to unravel metabolic alterations IBD. Design We measured 1684 different 8 short-chain branched-chain fatty acids stool samples 424 patients IBD 255 non-IBD controls. Regression analyses were used compare concentrations between cases controls determine relationship each participant’s lifestyle, characteristics gut microbiota composition. Moreover, genome-wide association analysis was conducted on metabolite levels. Results identified over 300 molecules that differentially abundant faeces The ratio sphingolipid L-urobilin could discriminate (AUC=0.85). found changes bile acid pool dysbiotic microbial communities strong metabolome microbiota. For example, abundance Ruminococcus gnavus positively associated tryptamine In addition, 158 associations dietary patterns, polymorphisms near NAT2 strongly coffee metabolism. Conclusion this large-scale analysis, are independent commonly overlooked confounders such as diet surgical history. Considering influence microbiome metabolites, our results pave way for future interventions targeting intestinal inflammation.

Language: Английский

Citations

74
Targeting Lactobacillus johnsonii to reverse chronic kidney disease DOI Creative Commons
Hua Miao, Fei Liu, Yanni Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 5, 2024

Abstract Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing CKD. Here, using microbiomics 480 participants including healthy controls and patients stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae- Lactobacillus - johnsonii correlated CKD progression, whose abundance strongly clinical markers. L. reduced rats adenine-induced supplementation ameliorated lesion. Serum indole-3-aldehyde (IAld), level negatively creatinine rats, decreased serum of induced unilateral ureteral obstruction (UUO) 5/6 nephrectomy (NX) as well late patients. Treatment IAld dampened lesion through aryl hydrocarbon receptor (AHR) signal or UUO, cultured 1-hydroxypyrene-induced HK-2 cells. Renoprotective effect was partially diminished AHR deficiency mice Our further data showed treatment attenuated by via increasing level. Taken together, targeting might reverse This study provides a deeper understanding how microbial-produced tryptophan metabolism affects host discovers potential pathways for prophylactic therapeutic treatments

Language: Английский

Citations

21
Sugar-sweetened beverage intake, gut microbiota, circulating metabolites, and diabetes risk in Hispanic Community Health Study/Study of Latinos DOI
Yanbo Zhang, Kai Luo, Brandilyn A. Peters

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2