Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum DOI Creative Commons
Suzanne van der Veldt, Guillaume Etter, Coralie‐Anne Mosser

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(8), P. e3001383 - e3001383

Published: Aug. 30, 2021

The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared tuning of LS GABAergic cells to those dorsal CA3 CA1 cells. We identified a significant number that are modulated by place, speed, acceleration, direction, as well conjunctions these properties, directly comparable spatially Interestingly, Bayesian decoding position based on reflected animal's location accurately activity pyramidal A portion showed stable codes over course multiple days, potentially reflecting long-term episodic memory. distributions exhibiting properties formed gradients along anterior-posterior dorsal-ventral axes LS, topographical organization inputs LS. Finally, show transsynaptic tracing neurons receiving excitatory input send projections hypothalamus medial septum, regions not targeted principal hippocampus. Together, our findings demonstrate robustly represents spatial, directional self-motion information is uniquely positioned relay this from hippocampus regions, thus occupying key within distributed memory network.

Language: Английский

Distinct circuits and molecular targets of the paraventricular hypothalamus decode visceral and somatic pain DOI Creative Commons
Yongchang Li,

Fu‐Chao Zhang,

Di Li

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

6
Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor DOI Creative Commons
Ila Mishra,

Wei Rose Xie,

Juan C. Bournat

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(4), P. 549 - 563.e8

Published: March 16, 2022

Language: Английский

Citations

26
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain DOI Creative Commons
Yongchang Li, Qian Wang, Mengge Li

et al.

Pain, Journal Year: 2022, Volume and Issue: 164(3), P. 625 - 637

Published: Aug. 19, 2022

Abstract Irritable bowel syndrome is a functional gastrointestinal disorder characterized by chronic visceral pain with complex etiology and difficult treatment. Accumulated evidence has confirmed that the sensitization of central nervous system plays an important role in development pain, whereas exact mechanisms action neural pathways remain largely unknown. In this study, distinct circuit was identified from paraventricular hypothalamic (PVH) to ventral lateral septal (LSV) region. This responsible for regulating pain. particular, data indicated PVH CaMKIIα-positive neurons inputs LSV were only activated colorectal distention rather than somatic stimulations. The PVH-LSV CaMKIIα + projection pathway further experiments containing viral tracer. Optogenetic inhibition suppressed selective activation evoked These findings suggest critical

Language: Английский

Citations

25
Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review DOI Creative Commons
Kristie Conde,

Shuzheng Fang,

Yong Xu

et al.

Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 7, 2023

The prevalence of obesity is rapidly increasing worldwide, while the development effective therapies lags behind. Although new therapeutic targets to alleviate are identified every day, and drug efficacy improving, adverse side effects increased health risks remain serious issues facing weight-loss industry. Serotonin, also known as 5-HT, has been extensively studied in relation appetite reduction weight loss. As a result, dozens upstream downstream neural 5-HT have identified, revealing multitude circuits involved mediating anorexigenic effect 5-HT. Despite rise fall several therapeutics recent decades, future target for therapy looks promising. This review focuses on history serotonin, state current central serotonin research, previous serotonergic therapies, treating individuals with obesity.

Language: Английский

Citations

14
A parabrachial to hypothalamic pathway mediates defensive behavior DOI Creative Commons
Fan Wang, Yuge Chen, Yuxin Lin

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 17, 2023

Defensive behaviors are critical for animal’s survival. Both the paraventricular nucleus of hypothalamus (PVN) and parabrachial (PBN) have been shown to be involved in defensive behaviors. However, whether there direct connections between them mediate remains unclear. Here, by retrograde anterograde tracing, we uncover that cholecystokinin (CCK)-expressing neurons lateral PBN (LPB CCK ) directly project PVN. By vivo fiber photometry recording, find LPB actively respond various threat stimuli. Selective photoactivation promotes aversion Conversely, photoinhibition attenuates rat or looming stimuli-induced flight responses. Optogenetic activation axon terminals within PVN glutamatergic Whereas chemogenetic pharmacological inhibition local prevent -PVN pathway activation-driven These data suggest recruit downstream engage Our study identifies a previously unrecognized role controlling

Language: Английский

Citations

13
Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict DOI Creative Commons

Dylan C.M. Yeates,

Dallas Leavitt, Sajeevan Sujanthan

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 10, 2022

Abstract The ability to resolve an approach-avoidance conflict is critical adaptive behavior. ventral CA3 (vCA3) and CA1 (vCA1) subfields of the hippocampus (vHPC) have been shown facilitate avoidance approach behavior, respectively, in face motivational conflict, but neural circuits by which this subfield-specific regulation implemented unknown. We demonstrate that two distinct pathways from these lateral septum (LS) contribute divergent control. In Long-Evans rats, chemogenetic inhibition vCA3- LS caudodorsal (cd) pathway potentiated towards a learned conflict-eliciting stimulus, while vCA1-LS rostroventral (rv) non-specifically. Additionally, vCA3-LScd inhibited animals were less hesitant explore food during environmental uncertainty, vCA1- LSrv took longer initiate exploration. These findings suggest vHPC influences multiple behavioral systems via differential projections LS, turn send inhibitory centres brain.

Language: Английский

Citations

21
Inhibitory actions of melanin‐concentrating hormone in the lateral septum DOI Creative Commons
Mikayla A. Payant, C Duncan Spencer, Nikita K. Koziel Ly

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(14), P. 3545 - 3574

Published: June 14, 2024

Abstract Melanin‐concentrating hormone (MCH) neurons can co‐express several neuropeptides or neurotransmitters and send widespread projections throughout the brain. Notably, there is a dense cluster of nerve terminals from MCH in lateral septum (LS) that innervate LS cells by glutamate release. The also key region integrating stress‐ anxiety‐like behaviours, which are emerging roles neurons. However, it not known if where peptide acts within LS. We analysed male female mice anteroposteriorly found spatial overlap between distribution pattern MCH‐immunoreactive (MCH‐ir) fibres with receptor Mchr1 mRNA hybridization MCHR1‐ir cells. This was most prominent along ventral border rostral part (LSr). Most MCHR1‐labelled lay adjacent to passing MCH‐ir fibres, but some varicosities directly contacted soma cilium thus performed whole‐cell patch‐clamp recordings MCHR1‐rich LSr regions determine how respond MCH. Bath application acute brain slices activated bicuculline‐sensitive chloride current hyperpolarized MCH‐mediated hyperpolarization blocked calphostin C, suggested inhibitory actions were mediated protein kinase C‐dependent activation GABA A receptors. Taken together, these findings define potential hotspots may elucidate contributions anxiety‐related feeding behaviours. image Key points have (LS), underlying behaviours system, function known. mRNA, MCHR1 expression Within regions, inhibited increasing conductance via manner. Electrophysiological effects been elusive, few studies described mechanisms action. Our demonstrated, our knowledge, first description G q ‐coupling slices, previously predicted cell primary culture models only. Together, defined mechanistic underpinnings for such as

Language: Английский

Citations

4
General anesthesia activates a central anxiolytic center in the BNST DOI Creative Commons

Dongye Lu,

Camille G. Uldry Lavergne,

Seonmi Choi

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114909 - 114909

Published: Oct. 25, 2024

Language: Английский

Citations

4
The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents DOI Creative Commons
Rachel Goh, Mingdao Mu, Wing‐Ho Yung

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 25, 2025

Abstract Obsessive-compulsive disorder (OCD), a disabling and notoriously treatment-resistant neuropsychiatric disorder, affects 2–3% of the general population is characterized by recurring, intrusive thoughts (obsessions) repetitive, ritualistic behaviors (compulsions). Although long associated with dysfunction within cortico-striato-thalamic-cortical circuits, thalamic role in OCD pathogenesis remains highly understudied literature. Here, we identified rat nucleus – reuniens (NRe) that mediates persistent, compulsive self-grooming behavior. Optogenetic activation this triggers immediate, excessive grooming strong irresistibility, increases anxiety, induces negative affective valence. A thalamic-hypothalamic pathway linking NRe to dorsal premammillary (PMd) was discovered mediate behavior render it defensive coping response stress, mirroring compulsions faced patients. Given close resemblance between clinical manifestations OCD, results from study highlight mediating OCD-like behaviors. This can be attributed NRe’s position at nexus an extensive frontal-striatal-thalamic network regulating cognition, emotion, stress-related behaviors, suggesting as potential novel target for intervention.

Language: Английский

Citations

0
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors DOI Creative Commons

Mengyue Zhu,

Jieqiao Peng,

Mi Wang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 1, 2025

Language: Английский

Citations

0