Quetiapine Reverses the Behavior and Myelination in Alcohol-Exposed Gestational Diabetes Mellitus Offspring Mice <i>via</i> ERK1/2 Signaling

Biological and Pharmaceutical Bulletin, Journal Year: 2025, Volume and Issue: 48(3), P. 323 - 335

Published: March 28, 2025

Gestational diabetes mellitus (GDM) is a glucose metabolism abnormality that first emerges during pregnancy and may negatively affect the behavioral neurodevelopmental outcomes of offspring. Quetiapine (QUE) has been shown to promote differentiation oligodendrocyte precursor cells (OPCs) protect oligodendrocytes myelination. To explore effects QUE on improving expression conditioned place preference (CPP) myelination in infralimbic cortex (IL) medial prefrontal alcohol-exposed GDM offspring mice, we evaluated CPP 5-week-old treated them with extracellular-regulated protein kinase (ERK) inhibitor U0126. Immunohistochemical staining compared numbers mature oligodendrocytes, OPCs, myelin levels. Immunofluorescence was employed examine OPC activation ERK1/2 signaling pathway. In offspring, increased considerably following alcohol exposure, whereas early treatment or U0126 significantly decreased expression. Meanwhile, exposure resulted substantial pathway within OPCs IL region, as well reduction differentiation, count, inhibited region markedly restored numbers, Collectively, enhanced after by regulating overactivation pathway, thus partially reversing loss ultimately

Language: Английский

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New directions in modelling dysregulated reward seeking for food and drugs

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 1037 - 1048

Published: Nov. 2, 2021

Language: Английский

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Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: April 27, 2021

Abstract Addiction is a chronic relapsing brain disease characterized by compulsive reward-seeking despite harmful consequences. The mechanisms underlying addiction are orchestrated transcriptional reprogramming in the reward system of vulnerable subjects. This study aims at revealing gene expression alterations across different types addiction. We analyzed publicly available transcriptome datasets prefrontal cortex (PFC) from palatable food and cocaine study. found 56 common genes upregulated PFC addicted mice these two studies, whereas most differentially expressed were exclusively linked to either or Gene ontology analysis shared revealed that contribute learning memory, dopaminergic synaptic transmission, histone phosphorylation. Network protein–protein interaction node among G protein-coupled receptors (Drd2, Drd1, Adora2a, Gpr6, Gpr88) downstream targets cAMP signaling pathway (Ppp1rb1, Rgs9, Pde10a) as core network Upon extending cell-type specific level, some molecular players selectively excitatory neurons, oligodendrocytes, endothelial cells. Overall, computational whole provides new insights into basis addiction-like behaviors PFC.

Language: Английский

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Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System—Implications for Health and Disease

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3661 - 3661

Published: April 1, 2021

The endocannabinoid system (ECS) employs a huge network of molecules (receptors, ligands, and enzymatic machinery molecules) whose interactions with other cellular networks have still not been fully elucidated. Endogenous cannabinoids are the primary function control multiple metabolic pathways. Maintenance tissue homeostasis by functional fine-tuning essential pathways is one key characteristics ECS. It implicated in variety physiological pathological states an attractive pharmacological target yet to reach its full potential. This review will focus on involvement ECS glucose lipid metabolism, food intake regulation, immune homeostasis, respiratory health, inflammation, cancer be substantiated using freely available data from open-access databases, experimental literature review. Future directions should envision capturing diversity exploiting options beyond classical suspects (exogenous cannabinoid receptor monomers) as signaling through heteromers offers new possibilities for different biochemical outcomes cell.

Language: Английский

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miRNA signatures associated with vulnerability to food addiction in mice and humans

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(10)

Published: March 29, 2022

Food addiction is characterized by a loss of behavioral control over food intake and associated with obesity other eating disorders. The mechanisms underlying this disorder are largely unknown. We aimed to investigate the changes in miRNA expression promoted animals humans their involvement hallmarks disorder. found sharp similitudes between signatures medial prefrontal cortex (mPFC) our animal cohort circulating levels human cohort, which allowed us identify several miRNAs potential interest development Tough decoy (TuD) inhibition miRNA-29c-3p mouse mPFC persistence response enhanced vulnerability developing addiction, whereas miRNA-665-3p compulsion-like behavior also vulnerability. In contrast, we that miRNA-137-3p did not lead addiction. Therefore, could be acting as protective factors regard believe elucidation these epigenetic will advances toward identifying innovative biomarkers possible future interventions for related disorders based on strategies now available modify activity expression.

Language: Английский

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