Decisions on a platter: Food biases and arousal alter reward learning DOI Open Access
Nina Rouhani, Cooper D. Grossman, Jamie D. Feusner

et al.

Published: Sept. 4, 2023

Food seeking and avoidance are powerful drivers of decision-making in healthy clinical populations. The urge to eat engages primary reward systems the brain, thought bias preference for energy-dense or high-calorie food more likely sate hunger. This process is however interrupted eating disorders where avoided. It nevertheless unclear how innate learned biases may interact with general processing predict learning decisions. We developed a novel paradigm investigate whether high- low-calorie alter large sample participants typical (‘TE’) disordered (‘DE’) behavior. Importantly, characteristics (high- vs. low-calorie) were completely incidental task goal maximizing monetary reward. An arousal manipulation involving win loss, examined heightened arousal, influence goal-directed behavior, enhances impact on learning. Consistent prior notions food-relevant biases, TE group better (i.e., made correct choices) when foods rewarding while DE rewarding. boosted this group-dependent bias. Fitting behavior reinforcement models enabled us identify distinct cognitive components underlying effect. Specifically, food-related was best explained accounting differences initial values rates (for positive prediction errors) foods. In other words, eaters showed their pre-experimental type food, respectively), as well extent which they from outcomes associated that preference. These findings provide mechanistic account reward-based choice, especially under arousal. Our results suggest interventions altering should target habit-directed mechanisms help mitigate maladaptive

Language: Английский

Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents DOI Creative Commons
Robyn M. Brown, Morgan H. James

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 123, P. 110717 - 110717

Published: Jan. 6, 2023

Language: Английский

Citations

20
Dietary intake in children and adolescents with food addiction: A systematic review DOI Creative Commons
Gabriela Carvalho Jurema Santos, Matheus Santos de Sousa Fernandes,

Pacheco Gabriela Carniel

et al.

Addictive Behaviors Reports, Journal Year: 2024, Volume and Issue: 19, P. 100531 - 100531

Published: Jan. 23, 2024

Food addiction (FA) is characterized by behavioral changes related to the consumption of palatable foods, marked dependence, impulsivity, and compulsion. Children adolescents are more vulnerable FA owing their significant ultra-processed foods. This review aims investigate differences in dietary intake pediatric populations with without FA. We conducted a systematic literature review. PubMed, ScienceDirect, PsycINFO databases were searched up July 2023. Potentially eligible studies independently checked two researchers. The methodological quality included was assessed using Joanna Briggs Institute Critical Appraisal Checklist for analytical cross-sectional studies. Of 4868 articles identified, six included. All had high quality. High calories fat observed children A diet analysis showed that such as sugary drinks, sweets, chips, Given these findings, we concluded childhood may be associated higher energy and, consequently, macronutrients. Few have examined relationship between food childhood, required.

Language: Английский

Citations

5
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice DOI
Jakub Wojcieszak, K Kuçzyńska,

A. Leszczyńska

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

0
Eating disorder symptoms and emotional arousal modulate food biases during reward learning in females DOI Creative Commons
Nina Rouhani, Cooper D. Grossman, Jamie D. Feusner

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Food seeking and avoidance engage primary reward systems to drive behavior. It is nevertheless unclear whether innate or learned food biases interact with general processing interfere goal-directed choice. To this end, we recruited a large non-clinical sample of females high eating-disorder symptoms ('HED') matched low ('LED') complete reward-learning task where the calorie content stimuli was incidental goal maximizing monetary reward. We find replicate low-calorie bias in HED high-calorie LED, reflecting strength pre-experimental food-reward associations. An emotional arousal manipulation shifts group-dependent across individual differences, interoceptive awareness predicting change. Reinforcement-learning models further identify distinct cognitive components supporting these group-specific biases. Our results highlight influence reinforcement-based mechanisms eliciting potentially maladaptive Disordered eating can disrupt rewarding value food. Here, authors show female that disorder symptoms, arousal, modulate goal-irrelevant during reinforcement learning.

Language: Английский

Citations

0
Punishment resistance for cocaine is associated with inflexible habits in rats DOI Creative Commons
Bradley O. Jones,

Morgan S. Paladino,

Adelis M. Cruz

et al.

Addiction Neuroscience, Journal Year: 2024, Volume and Issue: 11, P. 100148 - 100148

Published: Jan. 27, 2024

Addiction is characterized by continued drug use despite negative consequences. In an animal model, a subset of rats continues to self-administer cocaine footshock consequences, showing punishment resistance. We sought test the hypothesis that resistance arises from failure exert goal-directed control over habitual seeking. While habits are not inherently permanent or maladaptive, under conditions should encourage makes them maladaptive and inflexible. trained male female Sprague Dawley on seeking-taking chained schedule self-administration. then exposed four days testing in which was delivered randomly one-third trials. Before after (four pre-punishment ≥ post-punishment), we assessed whether seeking using outcome devaluation via satiety. found associated with habits, whereas sensitivity increased control. Although for predicted responding pre-punishment, it post-punishment. parallel studies food self-administration, similarly observed post-punishment but males, although both pre- females, indicating food-seeking females. These findings indicate related have become inflexible persist transition behavior.

Language: Английский

Citations

3
Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation DOI Creative Commons
Aida Mohammadkhani,

Caitlin Mitchell,

Morgan H. James

et al.

British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and orexin‐B, was discovered over 25 years ago immediately identified a central regulator sleep wakefulness. These peptides interact with two G‐protein coupled receptors, 1 (OX ) 2 receptors which are capable coupling to all heterotrimeric subfamilies, but primarily transduce increases in calcium signalling. Orexin neurons regulated by variety transmitter systems environmental stimuli that signal reward availability, including food drug related cues. also activated anticipation, stress, cues predicting motivationally relevant information, those drugs abuse, engage neuromodulatory systems, dopamine the ventral tegmental area (VTA) respond these signals. As such, have been characterized motivational activators coordinate range functions, feeding arousal, allow individual critical for survival. This review focuses on role orexins appetitive motivation highlights pathologies inappropriately high levels motivated arousal (overeating, anxiety substance use disorders) versus is impaired (depression).

Language: Английский

Citations

3
Amelioration impact of gut-brain communication on obesity control by regulating gut microbiota composition through the ingestion of animal-plant-derived peptides and dietary fiber: can food reward effect as a hidden regulator? DOI
Wei Jia, Jian Peng, Yan Zhang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11575 - 11589

Published: Aug. 1, 2023

Various roles of intestinal flora in the gut-brain axis response pathway have received enormous attention because their unique position flora-derived metabolites regulating hormones, inducing appetite, and modulating energy metabolism. Reward pathways brain play a crucial role communications, but mechanisms not been methodically understood. This review outlined by which leptin, ghrelin, insulin are influenced to regulate appetite body weight, focused on significance paraventricular nucleus ventromedial prefrontal cortex food reward. The vagus nerve mitochondria essential involved modulation neurotransmitters, neural signaling, neurotransmission communications. dynamic nutrient intake changes characteristics feeding activity requires participation transmit messages be completed. SCFAs, Bas, BCAAs, induced hormones mediate sensory information reward signaling host complex regulatory mechanism selection, composition significantly impacts this process. Food process obesity based communications expands new ideas for prevention treatment obesity.

Language: Английский

Citations

6
Use of experimental medicine approaches for the development of novel psychiatric treatments based on orexin receptor modulation DOI Creative Commons

Amy C. Beckenstrom,

Preciosa Coloma,

Gerard R. Dawson

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 147, P. 105107 - 105107

Published: Feb. 23, 2023

Language: Английский

Citations

5
Making and breaking habits: Revisiting the definitions and behavioral factors that influence habits in animals DOI Creative Commons

Sophia N. Handel,

Rachel J. Smith

Journal of the Experimental Analysis of Behavior, Journal Year: 2023, Volume and Issue: 121(1), P. 8 - 26

Published: Nov. 27, 2023

Abstract Habits have garnered significant interest in studies of associative learning and maladaptive behavior. However, habit research has faced scrutiny challenges related to the definitions methods. Differences conceptualizations habits between animal human create difficulties for translational research. Here, we review commonly used methods studying animals humans discuss potential alternative ways assess habits, such as automaticity. To better understand then focus on behavioral factors that been shown make or break animals, well mechanisms underlying influence these factors. We evidence habitual goal‐directed systems learn parallel they seem interact competitive cooperative manners. Finally, draw parallels responding compulsive drug seeking delineate similarities differences behaviors.

Language: Английский

Citations

5
Utility of ‘substance use disorder’ as a heuristic for understanding overeating and obesity DOI Creative Commons
Richard M. O’Connor, Paul J. Kenny

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2022, Volume and Issue: 118, P. 110580 - 110580

Published: May 27, 2022

Language: Английский

Citations

9