Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101826 - 101826
Published: March 15, 2023
Language: Английский
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(16)
Published: Oct. 18, 2022
Emergence of antibiotic-resistance pathogens has caused serious health issues and if the current trend is to continue, treatment infection will become complicated even unsuccessful due new antimicrobial resistance (AMR). Therefore, there a global drive identify methods treat develop better antibacterial materials therapy. Although more potent antibiotics have aided fight against microbes, they only offer temporary solution because future bacteria strains may resistant these drugs. Recently, application non-biological such as, electrical currents photothermal/dynamic therapies kill bacteria, reveal approaches design biomaterials, as complications stemming from drug-resistant can be obviated. Furthermore, recent research focused on mimicking surface patterns plants insects lotus leaves dragonfly wings. Bio-inspired micro/nano been replicated variety biomaterials improve bacterial other properties with good success. This an exciting area immense practical clinical potentials. In this review, advances in chemical/biological combat AMR are summarized related mechanisms discussed.
Language: Английский
Citations
42
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)
Published: June 4, 2023
Abstract With the promotion of nanochemistry research, large numbers nanomaterials have been applied in vivo to produce desirable cytotoxic substances response endogenous or exogenous stimuli for achieving disease‐specific therapy. However, performance is a critical issue that difficult improve and optimize under biological conditions. Defect‐engineered nanoparticles become most researched hot materials biomedical applications recently due their excellent physicochemical properties, such as optical properties redox reaction capabilities. Importantly, can be easily adjusted by regulating type concentration defects without requiring other complex designs. Therefore, this tutorial review focuses on defect engineering briefly discusses classification, introduction strategies, characterization techniques. Several representative defective are especially discussed order reveal relationship between properties. A series disease treatment strategies based engineered summarized. By summarizing design application nanomaterials, simple but effective methodology provided researchers therapeutic effects nanomaterial‐based platforms from science perspective.
Language: Английский
Citations
39
Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1762 - 1762
Published: Feb. 13, 2023
Due to the overuse of antibiotics, bacterial resistance has markedly increased become a global problem and major threat human health. Fortunately, in recent years, various new antibiotics have been developed through both improvements traditional discovery with novel mechanisms aim addressing decrease efficacy antibiotics. This manuscript reviews that approved for marketing last 20 years an emphasis on antibacterial properties, mechanisms, structure–activity relationships (SARs), clinical safety these Furthermore, current deficiencies, opportunities improvement, prospects are thoroughly discussed provide insights design development safer more potent
Language: Английский
Citations
38
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)
Published: July 20, 2023
Abstract The discovery of antibiotics has saved millions lives, but the emergence antibiotic‐resistant bacteria become another problem in modern medicine. To avoid or reduce overuse antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better smarter than conventional therapies. common goal smart (SAMs) is increase antibiotic efficacy function via an mechanism different from that order biological properties while reducing risk drug resistance. research development SAMs increasingly interdisciplinary because new designs require knowledge fields input/collaboration scientists fields. A good understanding energy conversion physiological characteristics cells bacteria, bactericidal structures components nature expected promote SAMs. In this review, importance multidisciplinary insights for emphasized, latest advances categorized discussed according pertinent disciplines including science, physiology, biomimicry.
Language: Английский
Citations
38
Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101826 - 101826
Published: March 15, 2023
Language: Английский
Citations
37