Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

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Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 23, 2024

Abstract Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity lack antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi 2 S 3‐X @PDA) designed using polydopamine (PDA) shell firmly anchored to surface sulfur vacancy‐rich bismuth sulfide nanorods NRs). Under near‐infrared light hydrogen peroxide, Bi @PDA significantly improves efficiency reactive oxygen species generation shows nearly 100% broad‐spectrum effect against multiple bacterial strains biofilms in vitro. Interestingly, activity PDA remarkably downregulates expression pro‐inflammatory factors promotes macrophage reprogramming toward proregenerative M2 phenotype. mouse wound model methicillin‐resistant Staphylococcus aureus biofilm infection, effectively eliminates through APCT/mild photothermal therapy, while reducing normal tissues regulating immune microenvironment, thereby promoting rapid healing. Overall, light‐controlled strategy, which provides both anti‐inflammatory functions, reliable tool combating infection

Language: Английский

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Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi 2 S 3 nanoheterojunctions that enable the charge separation expand scope catalytic reactions, aiming promote development improvement engineering is developed. this kind system, Fermi levels mediate formation internal electric field at interface guide recombination weak redox carriers, while strong carriers are retained. Thus, these high‐energy electrons holes able catalyze variety substrates in tumor microenvironment, such as reduction oxygen carbon dioxide superoxide radicals monoxide (CO), oxidation H O hydroxyl radicals, thus achieving sonodynamic therapy CO combined therapy. Mechanistically, generated reactive species damage DNA inhibit cancer cell energy levels, respectively, synergistically induce apoptosis. This study provides new insights into realization high efficiency low toxicity from unique perspective materials design. It anticipated therapeutic method will garner significant interest sonocatalytic nanomedicine field.

Language: Английский

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Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Language: Английский

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Defect‐Repaired g‐C₃N₄ Nanosheets: Elevating the Efficacy of Sonodynamic Cancer Therapy Through Enhanced Charge Carrier Migration

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(18)

Published: Feb. 7, 2024

Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains primary limiting factor for clinical application this treatment method. Here, defect-repaired graphene phase carbon nitride (g-C

Language: Английский

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Application of Artificial Intelligence in the Exploration and Optimization of Biomedical Nanomaterials

Nano Biomedicine and Engineering, Journal Year: 2023, Volume and Issue: 15(3), P. 342 - 353

Published: Sept. 1, 2023

Language: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Language: Английский

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Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 2, 2024

As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.

Language: Английский

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Artificial Bacteriophages for Treating Oral Infectious Disease via Localized Bacterial Capture and Enhanced Catalytic Sterilization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(41)

Published: Aug. 19, 2024

Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications robust artificial bacteriophages for localized bacterial capture enhanced in treatment oral infectious diseases. During whole process killing, CSHSs can efficiently via shortening between CSHSs, produce massive around bacteria, further iinducing admirable effect inhibition. By using mucosal infection periodontitis typical diseases, it is easily found that populations lesions animals after fall sharply, well‐developed nanosystem decrease inflammatory reaction promote hard or soft tissue repair. Together, high Fenton‐like activity, strong affinity, excellent overall safety nanoplatform promise its great therapeutic potential disinfection.

Language: Английский

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Unleashing the antibacterial potential of ZIFs and their derivatives: mechanistic insights

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3270 - 3291

Published: Jan. 1, 2025

Antibiotic resistance presents an alarming threat to global health, with bacterial infections now ranking among the leading causes of mortality. To address this escalating challenge, strategies such as antibiotic stewardship, development antimicrobial therapies, and exploration alternative treatment modalities are imperative. Metal-organic frameworks (MOFs), acclaimed for their outstanding biocompatibility in vivo biodegradability, promising avenues synthesis novel agents under mild conditions. Among these, zeolitic imidazolate (ZIFs), a remarkable subclass MOFs, have emerged potent antibacterial materials; efficacy which stems from porous structure, metal ion content, tunable functionalized groups. This could be further enhanced by incorporating or encapsulating ions, Cu, Fe, Ti, Ag, others. perspective aims underscore potential ZIFs underlying mechanisms including release generation reactive oxygen species (ROS), disruption cell walls, synergistic interactions other agents. These attributes position candidates advanced applications combating infections. Furthermore, we propose approach synthesizing derivatives, demonstrating exceptional against Escherichia coli Staphylococcus aureus. By highlighting benefits derivatives agents, emphasizes critical challenge resistance.

Language: Английский

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