Macrophages in immunoregulation and therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 22, 2023

Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.

Language: Английский

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Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 24, 2022

Abstract Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor stromal cells to promote proliferation, migration, invasion, angiogenesis immune evasion. Both ECM itself stiffening-induced mechanical stimuli may activate cell membrane receptors mechanosensors such as integrin, Piezo1 TRPV4, thereby modulating the malignant phenotype of cells. A better understanding how stiffness regulates progression will contribute development new therapeutics. rapidly expanding evidence in this research area suggests that regulators effectors represent potential therapeutic targets cancer. This review summarizes recent work on regulation cancer, effects progression, immunity drug resistance. We also discuss be druggable intervene Based these advances, future efforts can made develop more effective safe drugs interrupt stiffness-induced oncogenic signaling,

Language: Английский

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Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 9, 2022

Skin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors dynamic remodeling of extracellular matrices to maximize regeneration repair. Consequently, abnormalities in functions or pathways inevitably give rise side effects, such as dysregulated inflammation, hyperplasia nonmigratory epithelial cells, lack response growth factors, impedes angiogenesis fibrosis. These issues may cause delayed healing even non-healing states. Current clinical therapeutic approaches are predominantly dedicated preventing infections alleviating topical symptoms rather than addressing modulation microenvironments achieve targeted outcomes. Bioactive materials, relying on their chemical, physical, biological properties carriers bioactive substances, can affect promote at level. By mechanisms from perspective behaviors, this review discusses how materials within wounds during stages hemostasis, anti-inflammation, tissue deposition, matrix remodeling. A deeper understanding bound development more efficient for applications.

Language: Английский

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Tuning immunity through tissue mechanotransduction

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(3), P. 174 - 188

Published: Aug. 16, 2022

Language: Английский

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Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(12)

Published: Dec. 5, 2021

Abstract Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially temporally regulating biophysical biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted display deliver macrophage regulatory signals in a precise near‐physiological way, serving as powerful artificial microenvironments which explore direct fate macrophages. review starts discussing classification function macrophages, then introduces polarization macrophages different conventional wounds chronic wounds. Recent advances biomaterials balance phenotypes healing emphasized. Finally, looking ahead, potential ability biomaterial scaffolds modulate signaling produce environment conducive discussed.

Language: Английский

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Bone Repair Biomaterials: A Perspective from Immunomodulation

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(51)

Published: Oct. 9, 2022

Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus research has transitioned from bioinert bioactive biomaterials. many not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology revealed that immune system, which macrophages are critical components, plays essential regulatory role regeneration. this review, healing explored developments promote regeneration by modulating macrophage polarization improving osteoimmune microenvironment reviewed. This review provides reference development application repair immunomodulation perspective.

Language: Английский

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Inflammatory Microenvironment of Skin Wounds

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 1, 2022

Wound healing is a dynamic and highly regulated process that can be separated into three overlapping interdependent phases: inflammation, proliferation, remodelling. This review focuses on the inflammation stage, as it key stage of wound plays vital role in local immune response determines progression healing. Inflammatory cells, main effector cells inflammatory response, have been widely studied, but little attention has paid to immunomodulatory effects non-inflammatory extracellular matrix. In this review, we attempt deepen our understanding wound-healing microenvironment by focusing interactions between matrix, well their regulating during stage. We hope findings will provide new ideas for promoting tissue regeneration through regulation.

Language: Английский

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Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 26, 2022

Mechanical damage is one of the predisposing factors inflammation, and it runs through entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic diseases. The mechanism how forces induce inflammation not fully understood. Piezo1 a newly discovered mechanically sensitive ion channel. channel opens in response stimuli, transducing signals into an cascade cell leading tissue inflammation. A large amount evidence shows that plays vital role occurrence progression This mini-review briefly presents new responds different stresses trigger various tissues. discovery provides insights for treatment diseases related stress. Inhibiting transduction can inhibit improve outcome at early stage. pharmacology has shown bright prospects. development tissue-specific drugs clinical use may be target treating

Language: Английский

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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease

Neuron, Journal Year: 2022, Volume and Issue: 111(1), P. 15 - 29.e8

Published: Nov. 10, 2022

Language: Английский

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Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 26, 2023

Abstract Soft and stretchable electronics have emerged as highly promising tools for biomedical diagnosis biological studies, they interface intimately with the human body other systems. Most electronic materials devices, however, still Young’s moduli orders of magnitude higher than soft bio-tissues, which limit their conformability long-term biocompatibility. Here, we present a design strategy interlayer allowing use existing relatively high to versatilely realize devices ultralow tissue-level moduli. We demonstrated transistor arrays active-matrix circuits below 10 kPa—over two lower current state art. Benefiting from increased irregular dynamic surfaces, ultrasoft device created realizes electrophysiological recording on an isolated heart adaptability, spatial stability, minimal influence ventricle pressure. In vivo biocompatibility tests also demonstrate benefit suppressing foreign-body responses implantation. With its general applicability diverse this soft-interlayer overcomes material-level limitation imparting softness variety bioelectronic devices.

Language: Английский

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