Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem

Theranostics, Journal Year: 2023, Volume and Issue: 13(5), P. 1607 - 1631

Published: Jan. 1, 2023

Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that generally regarded as genetic disease with diverse intertumor and intratumor heterogeneity. This perspective review mainly outlines the up-to-date knowledge ecology NPC progression, presents number conceptual stepping-stones. At beginning, I explicitly advocate nature (cancer) not but an ecological disease: multidimensional spatiotemporal "unity evolution" pathological ecosystem. The hallmarks proposed to act factors population fitness. Subsequently, cells are described invasive species its metastasis multidirectional dispersal. foundational principles include intraspecific relationship (e.g. communication) interspecific competition, predation, parasitism mutualism) interpreted understand progression. "Mulberry-fish-ponds" model can well illustrate dynamic reciprocity Tumor-host interface transition zone cancer, tumor buddings should be recognized islands separated from mainland. It noted tumor-host has significantly molecular functional edge effect because curvature irregularity. Selection driving therapy including hyperthermia for patients, future perspectives in such field "ecological pathology", "multidimensional tumoriecology" also discussed. advance "nothing evolution or makes sense except light other". tree constructed comprehensively point out research direction. Taken together, establishment theory might provide novel framework paradigm our understanding complex causal process potential preventive therapeutic applications patients.

Language: Английский

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Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 9, 2023

Abstract The biological complexity of cancer represents a tremendous clinical challenge, resulting in the frequent failure current treatment protocols. In rapidly evolving scenario growing tumor, anticancer treatments impose drastic perturbation not only to cells but also tumor microenvironment, killing portion and inducing massive stress response survivors. Consequently, can act as double-edged sword by temporary while laying ground for therapy resistance subsequent disease progression. Cancer cell dormancy (or quiescence) is central theme evolution, being tightly linked tumor’s ability survive cytotoxic challenges, metastasize, resist immune-mediated attack. Accordingly, quiescent (QCCs) have been detected virtually all stages development. recent years, an increasing number studies focused on characterization quiescent/therapy resistant cells, unveiling QCCs core transcriptional programs, metabolic plasticity, mechanisms immune escape. At same time, our partial understanding quiescence reflects difficulty identify stable biomarkers/therapeutic targets control settings. This review focuses discoveries interrelated fields dormancy, stemness, resistance, discussing experimental evidences frame nonlinear dynamics approach, exploring possibility that may represent peril potential therapeutic resource.

Language: Английский

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Viral but not bacterial community successional patterns reflect extreme turnover shortly after rewetting dry soils

Nature Ecology & Evolution, Journal Year: 2023, Volume and Issue: 7(11), P. 1809 - 1822

Published: Sept. 28, 2023

Language: Английский

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Dormancy in the origin, evolution and persistence of life on Earth

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2038)

Published: Jan. 1, 2025

Life has existed on Earth for most of the planet’s history, yet major gaps and unresolved questions remain about how it first arose persisted. Early posed numerous challenges life, including harsh fluctuating environments. Today, many organisms cope with such conditions by entering a reversible state reduced metabolic activity, phenomenon known as dormancy. This process protects inactive individuals minimizes risk extinction preserving information that stabilizes life-system dynamics. Here, we develop framework understanding dormancy early Earth, beginning primer theory its core criteria. We hypothesize dormancy-like mechanisms acting chemical precursors in prebiotic world may have facilitated origin life. Drawing evidence from phylogenetic reconstructions fossil record, demonstrate is prevalent across tree life throughout deep time. These observations lead us to consider might shaped nascent living systems buffering stochastic processes small populations, protecting against large-scale planetary disturbances, aiding dispersal patchy landscapes facilitating adaptive radiations. Given fundamental easily evolved property also likely be feature elsewhere universe.

Language: Английский

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A Game of Life with dormancy

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 292(2039)

Published: Jan. 1, 2025

The factors contributing to the persistence and stability of life are fundamental for understanding complex living systems. Organisms commonly challenged by harsh fluctuating environments that suboptimal growth reproduction, which can lead extinction. Many species contend with unfavourable noisy conditions entering a reversible state reduced metabolic activity, phenomenon known as dormancy. Here, we develop Spore Life, model investigate effects dormancy on population dynamics. It is based Conway’s Game Life (GoL), deterministic cellular automaton where simple rules govern an individual its neighbours. For individuals would otherwise die, provides refuge in form inactive state. These dormant (spores) resuscitate when local improve. includes parameter α ∈ [ 0,1 form="postfix" stretchy="false">] controls survival probability spores, interpolating between GoL ( = 0 ) 1 ), while capturing stochastic dynamics intermediate regime < ). In addition identifying emergence unique periodic configurations, find spore increases average number active buffers populations from Contrary expectations, stabilization not result large long-lived seed bank. Instead, demographic patterns only require small resuscitation events. Our approach yields novel insight into what minimally required origins behaviours associated banks they generate.

Language: Английский

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What is microbial dormancy?

Trends in Microbiology, Journal Year: 2023, Volume and Issue: 32(2), P. 142 - 150

Published: Sept. 7, 2023

Life can be stressful. One way to deal with stress is simply wait it out. Microbes do this by entering a state of reduced activity and increased resistance commonly called 'dormancy'. But what dormancy? Different scientific disciplines emphasize distinct traits phenotypic ranges in defining dormancy for their microbial species system-specific questions interest. Here, we propose unified definition dormancy, using broad framework place earlier discipline-specific definitions new context. We then discuss how may improve our ability investigate multi-omics tools. Finally, leverage the diversity genomic mechanisms an extreme environment that challenges easy - permafrost.

Language: Английский

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Microbial inheritance through seed: a clouded area needs to be enlightened

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(1)

Published: Jan. 1, 2025

Language: Английский

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Beneath the surface: Unsolved questions in soil virus ecology

Soil Biology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109780 - 109780

Published: March 1, 2025

Language: Английский

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Spatial Populations with Seed-Bank: Renormalisation on the Hierarchical Group

Memoirs of the American Mathematical Society, Journal Year: 2025, Volume and Issue: 307(1553)

Published: Feb. 27, 2025

We consider a system of interacting diffusions labeled by geographic space that is given the hierarchical group Ω N \Omega _N order alttext="upper N element-of double-struck ∈ mathvariant="double-struck">N encoding="application/x-tex">N\in \mathbb {N} . Individuals live in colonies and are subject to resampling migration as long they active. Each colony has seed-bank into which individuals can retreat become dormant, suspending their until active again. The kernel structure: hop between at rate depends on hierarchical distance colonies. layered when dormant acquire colour determines latter allows us model seed-banks whose wake-up times have fat tail. analyse coupled stochastic differential equations describes population large-colony-size limit. For fixed , exhibits dichotomy coexistence (= locally multi-type equilibria) clustering mono-type equilibria). To identify clustering regime, i.e., range parameters controlling for clustering prevails, we apply necessary sufficient criterion derived (Electron. J. Probab. 27 (2022), Paper No. 18, 88, DOI 10.1214/21-ejp728. MR4377129) valid any countable Abelian group endowed with discrete topology. diffusion function does not play role this criterion. carry out multi-scale renormalisation analysis mean-field limit right-arrow normal infinity"> → mathvariant="normal">∞ encoding="application/x-tex">N\to \infty In particular, show block averages space-time scale alttext="k k encoding="application/x-tex">k \in perform renormalised alttext="k"> encoding="application/x-tex">k regime, after an appropriate scaling converges Fisher-Wright encoding="application/x-tex">k\to irrespective resampling. Thus, full universality large scales terms several subclasses speed scaled This turn mono-type clusters grow time. reduces compared without seed-bank. reduction result delicate interplay seed-bank, limit be worked explicitly.

Language: Английский

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Exploring plant and soil microbial communities as indicators of soil organic carbon in a California rangeland

Soil Biology and Biochemistry, Journal Year: 2023, Volume and Issue: 178, P. 108952 - 108952

Published: Jan. 5, 2023

Soil organic carbon (SOC) is increasingly a focus of land management and policy initiatives, due to the dual role it plays in soil health climate change mitigation. To manage SOC effectively, managers would benefit from proxy indicators that can assess concentrations forecast changes through time. Because inputs outputs are driven by plants microorganisms, plant microbial communities may be useful spatial or temporal changes. compare utility these ecological as indicators, we monitored surface subsurface soils across six-year period on ranch Central Coastal California, measured plant, fungal, bacterial/archaeal community composition. As expected, observed unique relationships between each candidate indicator SOC. Most notably, relative abundance putative copiotrophic oligotrophic bacterial phyla allowed us predict future concentration, did saprotrophic fungi cover perennial grass. Plant structure was also related content at time sampling. Combining improved our ability concentration changes, though were unable identify strongly explained historical preceded Our findings suggest measurements indicate so inform healthy soils.

Language: Английский

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