Pancreatic Cancer Organoids: An Emerging Platform for Precision Medicine? DOI Creative Commons
Evangelia Sereti, Irida Papapostolou, Konstantinos Dimas

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 890 - 890

Published: March 14, 2023

Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies, with remarkable resistance to treatment, poor prognosis, and clinical outcome. More efficient approaches are urgently needed improve patients’ survival. Recently, development organoid culture systems has gained substantial attention as an emerging preclinical research model. PDAC organoids have been developed study cancer biology, progression, treatment response, filling translational gap between in vitro vivo models. Here, we review rapidly evolving field their potential powerful tools that could pave way towards precision medicine for cancer.

Language: Английский

A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly DOI
Si‐Yong Qin, Jiaqi Feng, Yin‐Jia Cheng

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215600 - 215600

Published: Dec. 14, 2023

Language: Английский

Citations

36
Viscoelastic stiffening of gelatin hydrogels for dynamic culture of pancreatic cancer spheroids DOI Open Access
Han Nguyen, Chien‐Chi Lin

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 203 - 215

Published: Feb. 12, 2024

Language: Английский

Citations

12
Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment DOI Creative Commons
Maria Kalli, Triantafyllos Stylianopoulos

APL Bioengineering, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 21, 2024

Within the complex tumor microenvironment, cells experience mechanical cues-such as extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, shear stress-that significantly impact cancer cell behavior immune responses. Recognizing significance these cues not only sheds light on progression but also holds promise for identifying potential biomarkers that would predict therapeutic outcomes. However, standardizing methods studying how affect is challenging. This challenge stems from limitations traditional

Language: Английский

Citations

9
Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis DOI Creative Commons
Sun-Ah Lee,

G J Cho,

Do Young ‍Kim

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation mechano-responses. The biophysical interactions between cells and their dynamic are attributed to force-dependent alterations molecular pathways that trigger structural reorganization intracellular organelles associated genetic modifications. Recent studies underscore oxygen concentration metastasis. Suppressed levels promote development invasive phenotypes aggressive proliferation cells, accompanied remodeling encompassing modulation physical settings extracellular matrix. This review summarizes surroundings determining progression. Biophysical interpretation could provide further insights into novel biomedical technologies for therapeutic treatment.

Language: Английский

Citations

8
The importance of 3D fibre architecture in cancer and implications for biomaterial model design DOI
J. Ashworth, Thomas R. Cox

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(7), P. 461 - 479

Published: June 17, 2024

Language: Английский

Citations

8
Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma DOI Creative Commons
Xiu Wang,

Baoqin Song,

Mengru Wu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101694 - 101694

Published: March 1, 2025

Language: Английский

Citations

1
Profiling variable-number tandem repeat variation across populations using repeat-pangenome graphs DOI Creative Commons
Tsung-Yu Lu, Katherine M. Munson, Alexandra P. Lewis

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: July 12, 2021

Abstract Variable number tandem repeats (VNTRs) are composed of consecutive repetitive DNA with hypervariable repeat count and composition. They include protein coding sequences associations clinical disorders. It has been difficult to incorporate VNTR analysis in disease studies that use short-read sequencing because the traditional approach mapping human reference is less effective for divergent sequences. In this work, we solve short reads a repeat-pangenome graph (RPGG), data structure encodes both population diversity loci from multiple haplotype-resolved assemblies. We develop software build RPGG, RPGG estimate composition reads. discover VNTRs length stratified by continental population, expression quantitative trait loci, indicating will be critical future disease.

Language: Английский

Citations

43
Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research DOI Creative Commons
Tiago Ferreira, Adelina Gama, Fernanda Seixas

et al.

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 10(6), P. 379 - 379

Published: May 30, 2023

Breast cancer is one of the most common and well-known types among women worldwide frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas rats currently widely used animal for research laboratory context. Both have contributed to advancement scientific knowledge this field, and, a “One Health” approach, they allowed broad understanding specific biopathological pathways, influence environmental factors screening/discovery candidate therapies. This review aims clearly showcase similarities differences woman, dog rat concerning anatomical, physiological histological features mammary gland breast/mammary epidemiology, order better portray tumorigenesis, ensure appropriate conclusions extrapolation results species. We also discuss major aspects that stand out these The glands share structural similarities, especially with respect lactiferous ducts lymphatic drainage. In contrast, only duct per nipple. A comprehensive comparison between humans given special focus, as species several terms such age onset, hormonal etiology, risk factors, clinical course disease. Holistically, it clear each has advantages limitations researchers must consider during development experimental designs data analysis.

Language: Английский

Citations

21
3D Multispheroid Assembly Strategies towards Tissue Engineering and Disease Modeling DOI

Tong Zhu,

Yan Hu, Haitao Cui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Cell spheroids (esp. organoids) as 3D culture platforms are popular models for representing cell–cell and cell–extracellular matrix (ECM) interactions, bridging the gap between 2D cell cultures natural tissues. with spatially organized multiple types preferred gaining comprehensive insights into tissue pathophysiology constructing in vitro tissues disease because of complexities In recent years, an assembly strategy using (or living building blocks has been developed to construct complex spatial organization. Here, a overview advances multispheroid studies is provided. The different mechanisms techniques, i.e., automated directed assembly, noncontact remote programmed self‐assembly, introduced. processing steps, advantages, technical limitations existing methodologies summarized. Applications strategies modeling, drug screening, engineering, organogenesis reviewed. Finally, this review concludes by emphasizing persistent issues future perspectives, encouraging researchers adopt techniques generating advanced that better resemble real

Language: Английский

Citations

8
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer DOI Creative Commons
Ying Liu, Babatunde O. Okesola, David Osuna de la Peña

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: March 12, 2024

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression therapy resistance. To further the understanding of how stiffening microenvironment (TME) contributes to aggressiveness, three‐dimensional (3D) self‐assembling hydrogel disease model developed based on peptide amphiphiles (PAs, PA‐E3Y ) designed tailor stiffness. The displays nanofibrous architectures reminiscent native TME enables study invasive behavior PDAC cells. Enhanced tuneability stiffness demonstrated interacting thermally annealed aqueous solutions (PA‐E3Y h divalent cations create hydrogels mechanical properties ultrastructure similar ECM. It shown that levels found in induces ECM deposition, promotes epithelial‐to‐mesenchymal transition (EMT), enriches CD133 + /CXCR4 cancer stem cells (CSCs), subsequently enhances drug findings reveal 3D environment renders more aggressive therefore faithfully recapitulates vivo tumors.

Language: Английский

Citations

7