Stretchable Temperature-Responsive Multimodal Neuromorphic Electronic Skin with Spontaneous Synaptic Plasticity Recovery

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 8283 - 8293

Published: April 22, 2022

Multimodal electronic skin devices capable of detecting multimodal signals provide the possibility for health monitoring. Sensing and memory temperature deformation by human are great significance perception monitoring physiological changes body. Electronic is highly expected to have similar functions as skin. Here, implementing intrinsically stretchable neuromorphic transistors with mechanoreceptors thermoreceptors in an array, we realized temperature-responsive (STRM-NES) both sensory functions, which synaptic plasticity can be modulated multiple modalities, situ variations, stretching deformations. Temperature-responsive spontaneous recovery, temperature-dependent multitrial learning proposed. Furthermore, a array composed fully functional subcells demonstrated identify distributions variations at different regions conditions after various strains The STRM-NES has temperature- strain-responsive excellent self-healing, reusable capability, showing abilities sense, transmit, memory, recovery from external stimuli. It facilitate development wearable electronics, intelligent robotics, prosthetic applications.

Language: Английский

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Analogies of human speech and bird song: From vocal learning behavior to its neural basis

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 22, 2023

Vocal learning is a complex acquired social behavior that has been found only in very few animals. The process of animal vocal requires the participation sensorimotor function. By accepting external auditory input and cooperating with repeated imitation practice, stable pattern information output eventually formed. In parallel evolutionary branches, humans songbirds share striking similarities behavior. For example, their processes involve feedback, syntactic structures, sensitive periods. At same time, they have evolved hierarchical structure special forebrain regions related to motor control learning, which are organized closely associated cortex. comparing location, function, genome, transcriptome learning-related brain regions, it was confirmed songbird singing human language-related neural pathways certain analogy. These common characteristics make an ideal model for studying mechanisms language may be explained through similar mechanisms, can provide important insights treatment disorders.

Language: Английский

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CREB3 gain of function variants protect against ALS

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease arising from the loss of glutamatergic corticospinal neurons (CSN) cholinergic motoneurons (MN). Here, we performed comparative cross-species transcriptomics CSN using published snRNA-seq data motor cortex ALS control postmortem tissues, longitudinal RNA-seq on purified male Sod1G86R mice. We report that undergo ER stress altered mRNA translation, identify transcription factor CREB3 its regulatory network as resilience marker ALS, not only amongst vulnerable neuronal populations, but across all populations well other cell types. Using genetic epidemiologic analyses further rare variant CREB3R119G (rs11538707) positive modifier in ALS. Through gain function, decreases risk developing progression rate patients. Cross-species unravels markers Genetics epidemiology protective CREB3R119G.

Language: Английский

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Resilience of A Learned Motor Behavior After Chronic Disruption of Inhibitory Circuits

Published: April 23, 2025

Maintaining motor behaviors throughout life is crucial for an individual’s survival and reproductive success. The neuronal mechanisms that preserve behavior are poorly understood. To address this question, we focused on the zebra finch, a bird produces highly stereotypical song after learning it as juvenile. Using cell-specific viral vectors, chronically silenced inhibitory neurons in pre-motor nucleus called high vocal center (HVC), which caused drastic degradation. However, producing severely degraded vocalizations around 2 months, rapidly improved, animals could sing songs resembled original. In adult birds, single-cell RNA sequencing of HVC revealed silencing interneurons elevated markers microglia increased expression Major Histocompatibility Complex I (MHC I), mirroring changes observed juveniles during learning. Interestingly, adults restore their despite lesioning lateral magnocellular anterior neostriatum (LMAN), brain juvenile This suggests while molecular may overlap, utilize different recovery. Chronic acute electrophysiological recordings within its downstream target, robust archistriatum (RA), activity circuit permanently altered with higher spontaneous firing RA lower compared to control even had fully recovered. Together, our findings show complex learned can recover extended periods perturbed dynamics. These results loss tone be compensated by recovery partly local do not require circuits necessary

Language: Английский

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Resilience of A Learned Motor Behavior After Chronic Disruption of Inhibitory Circuits

Published: April 23, 2025

Maintaining motor behaviors throughout life is crucial for an individual’s survival and reproductive success. The neuronal mechanisms that preserve behavior are poorly understood. To address this question, we focused on the zebra finch, a bird produces highly stereotypical song after learning it as juvenile. Using cell-specific viral vectors, chronically silenced inhibitory neurons in pre-motor nucleus called high vocal center (HVC), which caused drastic degradation. However, producing severely degraded vocalizations around 2 months, rapidly improved, animals could sing songs resembled original. In adult birds, single-cell RNA sequencing of HVC revealed silencing interneurons elevated markers microglia increased expression Major Histocompatibility Complex I (MHC I), mirroring changes observed juveniles during learning. Interestingly, adults restore their despite lesioning lateral magnocellular anterior neostriatum (LMAN), brain juvenile This suggests while molecular may overlap, utilize different recovery. Chronic acute electrophysiological recordings within its downstream target, robust archistriatum (RA), activity circuit permanently altered with higher spontaneous firing RA lower compared to control even had fully recovered. Together, our findings show complex learned can recover extended periods perturbed dynamics. These results loss tone be compensated by recovery partly local do not require circuits necessary

Language: Английский

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Neural Activity During Call Production in the Female Zebra Finch Homolog of the Male Forebrain Song System

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(9)

Published: April 30, 2025

ABSTRACT Female zebra finches ( Taeniopygia guttata ) are unable to sing because of the vestigial development forebrain song control areas such as RA (nucleus robustus archistriatalis), a premotor nucleus pathway. In male finches, is also involved in call‐based vocal communication addition control. Here, we monitored activity neurons during freely behaving females using miniaturized telemetric recording device combined with audio recording. Neurons region showed associated stack and tet calls, two innate short‐range social calls produced by both sexes. units were active when called respond partner's call or initiate call. However, spontaneous, regularly firing units, typical RA, very rare or, found, no association output. Despite small number adult female neurons, these not functionless, but communication.

Language: Английский

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Emergence of sex-specific transcriptomes in a sexually dimorphic brain nucleus

Cell Reports, Journal Year: 2022, Volume and Issue: 40(5), P. 111152 - 111152

Published: Aug. 1, 2022

We present the transcriptomic changes underlying development of an extreme neuroanatomical sex difference. The robust nucleus arcopallium (RA) is a key component songbird vocal motor system. In zebra finch, RA initially monomorphic and then atrophies in females but grows up to 7-fold larger males. Mirroring this divergence, we show here that sex-differential gene expression expands from hundreds predominantly chromosome Z genes early thousands autosomal by time sexual dimorphism asymptotes. Male-specific developmental processes include cell axonal growth, synapse assembly activity, energy metabolism; female-specific polarity differentiation, transcriptional repression, steroid hormone immune signaling. Transcription factor binding site analyses support female-biased activation pro-apoptotic regulatory networks. extensive sex-specific reorganization provides insights into potential drivers sexually dimorphic neurodevelopment.

Language: Английский

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Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

eLife, Journal Year: 2023, Volume and Issue: 12

Published: May 9, 2023

Complex motor skills in vertebrates require specialized upper neurons with precise action potential (AP) firing. To examine how diverse populations of subserve distinct functions and the specific repertoire ion channels involved, we conducted a thorough study excitability controlling somatic function zebra finch. We found that robustus arcopallialis projection (RAPNs), key command for song production, exhibit ultranarrow spikes higher firing rates compared to non-vocal (dorsal intermediate arcopallium [AId] neurons). Pharmacological molecular data indicate this striking difference is associated expression RAPNs high threshold, fast-activating voltage-gated Kv3 channels, likely contain Kv3.1 (

Language: Английский

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A Wearable Master–Slave Rehabilitation Robot Based on an Epidermal Array Electrode Sleeve and Multichannel Electromyography Network

Advanced Intelligent Systems, Journal Year: 2023, Volume and Issue: 5(3)

Published: Jan. 18, 2023

Investigating electromyography (EMG) signals is vital to promote the development of both rehabilitative robots and understanding movement neural mechanism. Interactions between various muscle units are paramount be measured through network analysis, aiming reveal how information propagated integrated. Herein, an EMG using epidermal array electrode sleeve record multichannel EMGs constructed. Then, a master–slave rehabilitation robot by adopting as feature for intention recognition built. The results demonstrate that can with high quality, characterized better signal robustness higher performance. different finger movements evoke specific spatial patterns, dominated hub at in charge corresponding movement, proposed network‐based approach consistently achieves highest accuracy. Moreover, also shows relatively less influence length positions on recognition. Finally, system achieve 98.21% ± 2.37 accuracy online control. These provide novel theoretical practical basis prosthesis control hemiplegic hand rehabilitation.

Language: Английский

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The lncRNA lnc_AABR07044470.1 promotes the mitochondrial-damaged inflammatory response to neuronal injury via miR-214-3p/PERM1 axis in acute ischemic stroke

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: March 11, 2024

Abstract Purpose We investigated the role of lnc_AABR07044470.1 on occurrence and development acute ischemic stroke (AIS) neuronal injury by targeting miR-214-3p/PERM1 axis to find a novel clinical drug target prediction treatment AIS. Methods The mouse AIS animal model was used in vivo experiments hypoxia/reoxygenation cell vitro established. Firstly, infarction volume pathological changes hippocampal neurons were detected using HE staining. Secondly, rat primary neuron apoptosis flow cytometry assay. numbers neuron, microglia astrocytes immunofluorescence (IF). Furthermore, binding detection performed bioinformatics database double luciferase reporter Lnc_AABR07044470.1 localization fluorescence situ hybridization (FISH).Lnc_AABR07044470.1, miR-214-3pand PERM1mRNA expression RT-qPCR. NLRP3, ASC, Caspase-1 PERM1 protein Western blotting. IL-1β ELISA Results Mouse four-vessel occlusion could easily establish model, had an obvious time-dependence. staining showed that, compared with sham group, deteriorated group. significantly reduced, while activated. Moreover, confirmed site miR-214-3p Perm1. down-regulated miR-214-3pexpression up-regulated vivo. At same time, inflammasome pro-inflammatory factor vitro. over-expression inhibitor inhibit up-regulate Finally, transfected significant relieving injury. Conclusion promotes inflammatory response via

Language: Английский

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