Importance and vulnerability of lakes and reservoirs supporting drinking water in China

Fundamental Research, Journal Year: 2022, Volume and Issue: 3(2), P. 265 - 273

Published: March 12, 2022

Drinking water is closely related to human health, disease and mortality, contaminated drinking causes 485,000 deaths from diarrhea each year worldwide. China has been facing increasingly severe scarcity due both shortages poor quality. Ensuring safe clean a great challenge top priority, especially for with 1.4 billion people. In China, more than 4000 centralized sources including rivers, lakes reservoirs, groundwater have established serve urban residents. However, there little knowledge on the percentage, serving population quality of three source types. We collected nationwide data covering 395 prefecture-level county-level cities in two most populous provinces (Guangdong Shandong) examine their contribution importance. Geographically, types can be classified into clear regions exhibiting apparent differences respective contributions groundwater. further found that overall, reservoirs account 40.6% vs. river (30.8%) (28.6%) China. Lakes are particularly important densely populated eastern region, where they used as by 51.0% (318 million). Moreover, supply increasing better many cross-regional transfer projects. These results will useful government improve optimize establishment sources, which provide safeguard people's lives health realize sustainable development goals.

Language: Английский

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Properties of the “Z”‐Phase in Mn‐Rich P2‐Na_0.67Ni_0.1Mn_0.8Fe_0.1O₂ as Sodium‐Ion‐Battery Cathodes

Small, Journal Year: 2023, Volume and Issue: 19(20)

Published: Feb. 20, 2023

P2 layered oxides have attracted more and attention as cathode materials of high-power sodium-ion batteries (SIBs). During the charging process, release sodium ions leads to layer slip, which transformation phase into O2 phase, resulting in a sharp decline capacity. However, many do not undergo -O2 transition during discharging, but form "Z" phase. It is proved that iron-containing compound Na0.67 Ni0.1 Mn0.8 Fe0.1 formed symbiotic structure P O high-voltage through ex-XRD HAADF-STEM. material undergoes structural change -OP4 . With increase voltage, O-type superposition mode increases an ordered OP4 -type disappears after further pure 57 Fe-Mössbauer spectroscopy revealed no migration Fe detected. The O-Ni-O-Mn-Fe-O bond metal MO6 (M = Ni, Mn, Fe) octahedron can inhibit elongation Mn-O improve electrochemical activity so P2-Na0.67 has excellent capacity 172.4 mAh g-1 coulombic efficiency close 99% at 0.1C.

Language: Английский

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Hierarchical Synergistic Structure for High Resolution Strain Sensor with Wide Working Range

Small, Journal Year: 2023, Volume and Issue: 19(34)

Published: May 8, 2023

Strain sensors have been attracting tremendous attention for the promising application of wearable devices in recent years. However, trade-off between high resolution, sensitivity, and broad detection range is a great challenge strain sensors. Herein, novel design hierarchical synergistic structure (HSS) Au micro cracks carbon black (CB) nanoparticles reported to overcome this challenge. The sensor based on designed HSS exhibit sensitivity (GF > 2400), resolution (0.2%) even under large loading strain, (>40%), outstanding stability (>12000 cycles), fast response speed simultaneously. Further, experiments simulation results demonstrate that layer greatly changed morphology micro-cracks, forming micro-scale nano-scale particles, thus enabling effect double conductive network micro-cracks CB nanoparticles. Based excellent performance, successfully applied monitoring tiny signals carotid pulse during body movement, which illustrates potential health monitoring, human-machine interface, human motion detection, electronic skin.

Language: Английский

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USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 13, 2024

Abstract A hallmark of tumor cells, including bladder cancer (BLCA) is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which crucial in regulating glycolysis, amplified and activated BLCA. However, direct targeting the c-Myc oncoprotein, regulates glycolytic metabolism, presents great challenges necessitates discovery a more clarified regulatory mechanism to develop selective targeted therapy. In this study, siRNA library deubiquitinases identified candidate enzyme named USP43, may regulate metabolism transcriptional activity. Further investigation using functional assays molecular studies revealed USP43/c-Myc positive feedback loop that contributes progression Moreover, USP43 stabilizes by deubiquitinating at K148 K289 primarily through deubiquitinase Additionally, upregulation protein BLCA increased chance interaction with interfered FBXW7 access degradation c-Myc. These findings suggest potential therapeutic target for indirectly oncoprotein consequently enhancing efficacy treatment.

Language: Английский

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Spatio-temporal patterns and spillover effects of synergy on carbon dioxide emission and pollution reductions in the Yangtze River Delta region in China

Sustainable Cities and Society, Journal Year: 2024, Volume and Issue: 107, P. 105419 - 105419

Published: April 8, 2024

Language: Английский

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Scalable Electrosynthesis of Formamide through C−N Coupling at the Industrially Relevant Current Density of 120 mA cm⁻²

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 15, 2022

The scalable and durable electrosynthesis of high-valued organonitrogen compounds from carbon- nitrogen-containing small molecules, especially operating at a high current density, is highly desirable. Here, one-pot electrooxidation method to synthesize formamide (HCONH2 ) methanol ammonia over commercial boron-doped diamond (BDD) catalyst reported. selectivity Faradaic efficiency (FE HCONH2${{_{{\rm HCONH}{_{2}}}}}$ achieve 73.2 % 41.2 the density 120 mA cm-2 with durability. C-N bond originates nucleophilic attack on an aldehyde-like intermediate. Impressively, 8 L electrolyzer employed for pilot plant test 2200 cm2 BDD electrode, which exhibits 33.5 FE (current: 264 A) yield rate 36.9 g h-1 , demonstrating potential this technique large-scale formamide.

Language: Английский

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Recent advances in in situ and operando characterization techniques for Li₇La₃Zr₂O₁₂-based solid-state lithium batteries

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(5), P. 1479 - 1538

Published: Jan. 1, 2023

Various in situ / operando characterization techniques provide a comprehensive understanding of LLZO-based solid-state lithium batteries.

Language: Английский

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DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 27, 2023

Abstract To date, most studies on the DNA polymerase, POLD1, have focused effect of POLD1 inactivation mutations in tumors. However, implications high expression tumorigenesis remains elusive. Here, we determine that has a pro-carcinogenic role bladder cancer (BLCA) and is associated to malignancy prognosis BLCA. Our demonstrate promotes proliferation metastasis BLCA via MYC. Mechanistically, stabilizes MYC manner independent its’ polymerase activity. Instead, attenuates FBXW7-mediated ubiquitination degradation by directly binding homology box 1 domain competitively with FBXW7. Moreover, find forms complex promote transcriptional activity In turn, increases , forming POLD1-MYC positive feedback loop enhance Overall, our study identifies as promotor BCLA driven mechanism suggest its potential biomarker for

Language: Английский

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Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic

EBioMedicine, Journal Year: 2024, Volume and Issue: 100, P. 104972 - 104972

Published: Jan. 21, 2024

The importance of EZH2 as a key methyltransferase has been well documented theoretically. Practically, the first inhibitor Tazemetostat (EPZ6438), was approved by FDA in 2020 and is used clinic. However, for most solid tumors it not effective desired scope clinical indications limited, suggesting that targeting its enzymatic activity may be sufficient. Recent technologies focusing on degradation protein have drawn attention due to their potential robust effects. This review focuses molecular mechanisms regulate stability via post-translational modifications (PTMs), mainly including ubiquitination, phosphorylation, acetylation. In addition, we discuss recent advancements multiple proteolysis chimeras (PROTACs) strategies latest degraders can downregulate protein. We aim highlight future directions expand application novel inhibitors both stability.

Language: Английский

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In Situ Construction of Hollow Coral‐Like Porous S‐Doped g‐C₃N₄/ZnIn₂S₄ S‐Scheme Heterojunction for Efficient Photocatalytic Hydrogen Evolution

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 3, 2024

The rational design of visible-light-responsive catalysts is crucial for converting solar energy into hydrogen to promote sustainable development. In this work, a C─S─C bond introduced g-C

Language: Английский

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