Regenerative and restorative medicine for eye disease

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 1149 - 1156

Published: June 1, 2022

Language: Английский

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Metaverse Wearables for Immersive Digital Healthcare: A Review

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Sept. 22, 2023

The recent exponential growth of metaverse technology has been instrumental in reshaping a myriad sectors, not least digital healthcare. This comprehensive review critically examines the landscape and future applications wearables toward immersive key technologies advancements that have spearheaded metamorphosis are categorized, encapsulating all-encompassed extended reality, such as virtual augmented mixed other haptic feedback systems. Moreover, fundamentals their deployment assistive healthcare (especially for rehabilitation), medical nursing education, remote patient management treatment investigated. potential benefits integrating into paradigms multifold, encompassing improved prognosis, enhanced accessibility to high-quality care, high standards practitioner instruction. Nevertheless, these without inherent challenges untapped opportunities, which span privacy protection, data safeguarding, innovation artificial intelligence. In summary, research trajectories circumvent hurdles also discussed, further augmenting incorporation within infrastructures post-pandemic era.

Language: Английский

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Frontier applications of retinal nanomedicine: progress, challenges and perspectives

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Language: Английский

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Bionic Engineered Protein Coating Boosting Anti‐Biofouling in Complex Biological Fluids

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(6)

Published: Nov. 11, 2022

Abstract Implantable medical devices have been widely applied in diagnostics, therapeutics, organ restoration, and other biomedical areas, but often suffer from dysfunction infections due to irreversible biofouling. Inspired by the self‐defensive “vine‐thorn” structure of climbing thorny plants, a zwitterion‐conjugated protein is engineered via grafting sulfobetaine methacrylate (SBMA) segments on native bovine serum albumin (BSA) molecules for surface coating antifouling applications complex biological fluids. Unlike traditional synthetic polymers which operation requires arduous pretreatments, BSA@PSBMA (PolySBMA conjugated BSA) can achieve facile surface‐independent various substrates through simple dipping/spraying method. Interfacial molecular force measurements adsorption tests demonstrate that substrate‐foulant attraction significantly suppressed strong interfacial hydration steric repulsion bionic BSA@PSBMA, enabling surfaces exhibit superior resistance biofouling broad spectrum species including proteins, metabolites, cells, biofluids under conditions. This work provides an innovative paradigm using proteins generate with extraordinary capability desired properties bioengineering applications.

Language: Английский

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Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 4, 2022

Abstract Localized stimulation of the inner retinal neurons for high-acuity prosthetic vision requires small pixels and minimal crosstalk from neighboring electrodes. Local return electrodes within each pixel limit crosstalk, but they over-constrain electric field, thus precluding efficient with subretinal smaller than 55 μm. Here we demonstrate a high-resolution based on novel design photovoltaic array, where field confinement is achieved dynamically, leveraging adjustable conductivity diodes under forward bias to turn designated into transient returns. We validated computational modeling in such an optically-controlled circuit by in-vitro in-vivo measurements. Most importantly, using this strategy, demonstrated that grating acuity 40 μm matches pitch, while 20 pixels, it reaches 28 natural visual resolution rats. This method enables customized shaping individual thickness distance implant, paving way higher atrophic macular degeneration.

Language: Английский

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2D Semiconductor‐Based Optoelectronics for Artificial Vision

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(52)

Published: Sept. 8, 2023

Abstract Artificial retina technologies aim to restore visual function by mimicking the natural processes of eye. These biomimetic devices can convert light into electrical signals that brain interpret as information, bypassing damaged or non‐functional cells To be effective, these should possess high sensitivity light, spatial resolution, biocompatibility, power efficiency, and so on. Recently, 2D semiconductor materials have appeared a promising candidate for artificial retinal devices, thanks their excellent optoelectronic properties, ultrathin body, flexible nature, biocompatibility. Here recent developments in field semiconductors‐based optoelectronics recovery are reviewed potential applications discussed. The photodetector, memory, synapse mechanisms utilized systems based on summarized. Additionally, range application scenarios inspired vision is explored. Finally, it concluded with an overview critical technical challenges strategies must addressed successful development technologies. It also highlights new other fields, such robotics intelligence.

Language: Английский

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Optical neuromodulation at all scales: from nanomaterials to wireless optoelectronics and integrated systems

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(10), P. 3326 - 3352

Published: Jan. 1, 2023

This review summarizes optical nanomaterials, devices, and systems for neuromodulation. We describe their structures, working principles bioelectronic applications with challenges prospects.

Language: Английский

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Virtual Human Retina: Simulating Neural Signalling, Degeneration, and Responses to Electrical Stimulation

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Current brain-based visual prostheses pose significant challenges impeding adoption such as the necessarily complex surgeries and occurrence of more substantial side effects due to sensitivity brain. This has led much effort toward vision restoration being focused on approachable part brain - retina. Here we introduce a novel, parameterized simulation platform that enables study human retinal degeneration optimization stimulation strategies. The bears immense potential for patient-specific tailoring serves enhance artificial solutions individuals with impairments. Our virtual retina is developed using software package, NEURON. supports large-scale simulations over 10,000 neurons whilst upholding strong biological plausibility multiple important pathways detailed network properties. comprehensive three-dimensional model includes photoreceptors, horizontal cells, bipolar amacrine midget parasol ganglion connectivity across various eccentricities (1 mm 5 from fovea) in constructed electrophysiology, immunohistology, optical coherence tomography imaging data healthy degenerate retinas. We validated our by replicating numerous experimental observations primate retina, particular focus degeneration. simulated interactions between diseased retinas state-of-the-art implants, shedding light limitations commercial prostheses. results suggested appropriate settings intraretinal prototype devices could leverage network-mediated activation achieve mosaics alike retina's response natural light, promoting prospect naturalistic vision. additionally highlights importance controlling inhibitory circuits induce functionally relevant activity. demonstrates this package its utility valuable tool engineers, scientists, clinicians design optimisation both research educational applications.

Language: Английский

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Advances in visual prostheses: engineering and biological challenges

Progress in Biomedical Engineering, Journal Year: 2022, Volume and Issue: 4(3), P. 032003 - 032003

Published: July 1, 2022

Abstract Vision is an extraordinary sense through which we can appreciate the beauty of world live in, gain invaluable knowledge and communicate with others using visual expression arts. On contrary, blindness a threatening medical condition disrupting life affected people their families. Therefore, restoring sight one open challenges our society. Today, synergistic convergence science technology holds potential to provide blind patients artificial vision prostheses: type implantable device able reactivate neurons electrical stimulation. Although clinical trials showed that restoration still far away, significant technological advances make prostheses valuable solution for patients. This review not only description state-of-the-art. Instead, it provides reader update on recent developments, critical discussion challenges, overview promising future directions.

Language: Английский

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Retinal Prostheses: Engineering and Clinical Perspectives for Vision Restoration

Sensors, Journal Year: 2023, Volume and Issue: 23(13), P. 5782 - 5782

Published: June 21, 2023

A retinal prosthesis, also known as a bionic eye, is device that can be implanted to partially restore vision in patients with diseases have resulted the loss of photoreceptors (e.g., age-related macular degeneration and retinitis pigmentosa). Recently, there been major breakthroughs prosthesis technology, creation numerous types implants, including epiretinal, subretinal, suprachoroidal sensors. These devices stimulate remaining cells retina electric signals create visual sensation. literature review pre-clinical clinical studies published between 2017 2023 conducted. This narrative delves into anatomy, physiology, pathology, principles underlying electronic prostheses. Engineering aspects are explored, electrode–retina alignment, electrode size material, charge density, resolution limits, spatial selectivity, bidirectional closed-loop systems. article discusses aspects, focusing on safety, adverse events, function, outcomes, importance rehabilitation programs. Moreover, ongoing debate over whether implantable still offer promising approach for treatment diseases, considering recent emergence cell-based gene-based therapies well optogenetics. compares prostheses these alternative therapies, providing balanced perspective their advantages limitations. The advancements technology outlined, emphasizing progress engineering outlook While acknowledging challenges complexities this highlights significant potential restoration individuals calls continued research development refine enhance performance, ultimately improving patient outcomes quality life.

Language: Английский

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