Current Status and Prospects of Clinical Treatment of Osteosarcoma DOI Creative Commons
Zong-Yuan Jiang, Ji‐Bin Liu, Xiaofeng Wang

et al.

Technology in Cancer Research & Treatment, Journal Year: 2022, Volume and Issue: 21

Published: Jan. 1, 2022

Osteosarcoma, one of the common malignant tumors in skeletal system, originates mesenchymal tissue, and most susceptible area occurrence is metaphysis with its abundant blood supply. Tumors are characterized by highly spindle stromal cells that can produce bone-like tissue. Most osteosarcoma primary, a few secondary. Osteosarcoma occurs primarily children adolescents undergoing vigorous bone growth development. cases involve rapid tumor development early metastasis. In recent years, research has grown areas molecular biology, imaging medicine, biological materials, applied anatomy, surgical techniques, biomechanics, comprehensive treatment tumors. With developments biology tissue bioengineering, methods have also made great progress, especially limb salvage treatment, which significantly enhances quality life after surgery improves 5-year survival rate patients This article provides review salvage, immunotherapy, gene therapy, targeted therapy from traditional amputation to neoadjuvant chemotherapy, providing reference for current clinical treatments osteosarcoma.

Language: Английский

Layered double hydroxide-based nanomaterials for biomedical applications DOI
Tingting Hu, Zi Gu, Gareth R. Williams

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

Citations

259
Flexible Accelerated‐Wound‐Healing Antibacterial MXene‐Based Epidermic Sensor for Intelligent Wearable Human‐Machine Interaction DOI
Mingkun Li, Yunfei Zhang,

Lishuyi Lian

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(47)

Published: Sept. 17, 2022

Abstract Flexible epidermic sensors made from conductive hydrogels are holding bright potential in personalized healthcare, multifunctional electronic skins, and human‐machine interfaces. However, it is still a great challenge to simultaneously realize hydrogel‐based with reliable self‐healing ability remarkable sensing performances high‐performance healthcare (especially electrophysiological signals) for wearable interaction, as well accelerated wound healing subsequent medical treatment together. Herein, flexible healable sensor assembled the facilely prepared antibacterial MXene hydrogel efficiently sensitively interaction. The as‐prepared possesses enhanced mechanical performance, outstanding capability, injectability, facile degradability, excellent biocompatibility, robust ability, which capable of being into monitor human movements rehabilitation training, detect tiny signals diagnosis cardiovascular‐ muscle‐related diseases, be employed In addition, can utilized treat infection effectively accelerate healing. Thus, sheds light on preparing integration personal health smart interaction next‐generation artificial skins.

Language: Английский

Citations

191
Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects DOI Creative Commons
Pengfei Zhang, Yufen Xiao, Xue Sun

et al.

Med, Journal Year: 2022, Volume and Issue: 4(3), P. 147 - 167

Published: Dec. 21, 2022

Language: Английский

Citations

117
Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence DOI Creative Commons

Bangfeng Wang,

Yiwei Li, Mengfan Zhou

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 11, 2023

Abstract The frequent outbreak of global infectious diseases has prompted the development rapid and effective diagnostic tools for early screening potential patients in point-of-care testing scenarios. With advances mobile computing power microfluidic technology, smartphone-based health platform drawn significant attention from researchers developing devices that integrate optical detection with artificial intelligence analysis. In this article, we summarize recent progress these platforms, including aspects chips, imaging modalities, supporting components, software algorithms. We document application platforms terms objects, molecules, viruses, cells, parasites. Finally, discuss prospects future platforms.

Language: Английский

Citations

111
Oral Hydrogel Microbeads-Mediated In Situ Synthesis of Selenoproteins for Regulating Intestinal Immunity and Microbiota DOI
Jiang Ouyang,

Bo Deng,

Binhua Zou

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(22), P. 12193 - 12205

Published: May 19, 2023

Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as protein drug that is easily denatured or degraded the acidic environment of stomach, efficient oral delivery selenoprotein great challenge. Herein, we innovated an hydrogel microbeads-based biochemical strategy can situ synthesize selenoproteins, therefore bypassing necessity harsh conditions for while effectively generating selenoproteins therapeutic applications. The microbeads were synthesized by coating hyaluronic acid-modified selenium nanoparticles with protective shell calcium alginate (SA) hydrogel. We tested this mice bowel disease (IBD), one most representative diseases related to intestinal immunity microbiota. Our results revealed microbeads-mediated synthesis could prominently reduce proinflammatory cytokines secretion mediate (e.g., neutrophils monocytes increase regulatory T cells) relieve colitis-associated symptoms. This was also able regulate gut microbiota composition (increase probiotics abundance suppress detrimental communities) maintain homeostasis. Considering widely associated cancers, infections, inflammations, etc., might be possibly applied broadly tackle various diseases.

Language: Английский

Citations

108
Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties DOI

Yunxin Tang,

Anuraj Varyambath,

Yuanchen Ding

et al.

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(19), P. 5369 - 5390

Published: Jan. 1, 2022

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials.

Language: Английский

Citations

103
Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy DOI Creative Commons
Shuang Bai,

Yulu Lan,

Shiying Fu

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 18, 2022

As the indispensable second cellular messenger, calcium signaling is involved in regulation of almost all physiological processes by activating specific target proteins. The importance ions (Ca

Language: Английский

Citations

102
Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy DOI Creative Commons
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Language: Английский

Citations

90
Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review DOI

Yongliang Ouyang,

Jiulong Zhao, Shige Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 227, P. 505 - 523

Published: Dec. 8, 2022

Language: Английский

Citations

88
Oral zero-valent-molybdenum nanodots for inflammatory bowel disease therapy DOI Creative Commons
Chen Zhang, Han Wang,

Xinhui Yang

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(37)

Published: Sept. 16, 2022

Inflammatory bowel disease (IBD) affects millions of people each year. The overproduction reactive oxygen species (ROS) plays a critical role in the progress IBD and will be potential therapeutic target. Here, we synthesize kind oral zero-valent-molybdenum nanodots (ZVMNs) for treatment by scavenging ROS. These ultrasmall ZVMNs can successfully pass through gastric acid then absorbed intestine. It has been verified that down-regulate quantity ROS reduce colitis mouse model without distinct side effects. In addition, RNA sequencing reveals further mechanism protect colon tissues from oxidative stress inhibiting nuclear factor κB signaling pathway reducing production excessive pro-inflammatory factors. Together, offer promising alternative option patients suffering IBD.

Language: Английский

Citations

83