Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 2943 - 2957

Published: Jan. 23, 2023

The microenvironments with high reactive-oxygen-species (ROS) levels, inflammatory responses, and oxidative-stress effects in diabetic ulcer wounds, leading to poor proliferation differentiation of stem cells, severely inhibit their efficient healing. Here, overcome the unbalanced multielectron reactions ROS catalysis, we develop a cobalt selenide-based biocatalyst an amorphous Ru@CoSe nanolayer for ultrafast broad-spectrum catalytic ROS-elimination. Owing enriched electrons more unoccupied orbitals Ru atoms, nanolayer-equipped displays excellent catalase-like kinetics (maximal reaction velocity, 23.05 μM s–1; turnover number, 2.00 s–1), which exceeds most currently reported metal compounds. theoretical studies show that atoms act as "regulators" tune electronic state Co sites modulate interaction oxygen intermediates, thus improving reversible redox properties active sites. Consequently, can efficiently rescue mesenchymal cells maintain angiogenic potential oxidative stress environment. In vivo experiments reveal superior ROS-elimination ability on wound. This study offers effective nanomedicine ROS-scavenging healing wounds also provides strategy design biocatalytic compounds via bringing structures.

Language: Английский

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Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis

Science Advances, Journal Year: 2023, Volume and Issue: 9(21)

Published: May 26, 2023

Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease. Here, we report an polyphenol-armored nanomedicine based on tumor necrosis factor-α (TNF-α)-small interfering RNA gallic acid-mediated graphene quantum dot (GAGQD)-encapsulated bovine serum albumin nanoparticle, with a chitosan tannin acid (CHI/TA) multilayer. Referred to "armor," the CHI/TA multilayer resists harsh environment of gastrointestinal tract adheres inflamed colon sites in targeted manner. TA provides antioxidative stress prebiotic activities modulate diverse microbiota. Moreover, GAGQD protected TNF-α-siRNA delivery. Unexpectedly, armored suppressed hyperactive immune responses modulated bacterial homeostasis mouse model acute colitis. Notably, alleviated anxiety- depression-like behaviors cognitive impairment mice This armor strategy sheds light effect microbiome-brain interactions.

Language: Английский

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Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 5, 2023

Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.

Language: Английский

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Rational Design of Orally Administered Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)

Published: Aug. 23, 2023

Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy established address multifaceted demands, including intrinsic stability, radioactivity, solubility, gut microbiome toxicity, biomimetic elements, intermediate frontier molecular orbitals, reaction energy barriers, negative charges, acid tolerance. Ni3 S4 selected as best matching material from 146 323 candidates, which exhibits superoxide dismutase-catalase bienzyme-like activity 3.13- 1.80-fold more active than natural enzymes. As demonstrated mouse model, stable gastrointestinal tract without toxicity specifically targets diseased colon alleviate oxidative stress. RNA 16S rRNA sequencing analyses show that effectively inhibits cellular pathways pro-inflammatory factors restores microbiota. This study not develops highly efficient administered cascade nanozyme offers next-generation paradigm rational design nanomedicine through data-driven approaches.

Language: Английский

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Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: July 28, 2023

Abstract Abnormal activation of the gut mucosal immune system and a highly dysregulated microbiota play essential roles in progression inflammatory bowel disease (IBD). The clinical treatment IBD remains challenging, with first‐line drugs showing limited efficacy significant side effects. A reactive oxygen species (ROS)‐activated CO versatile nanomedicine (CMPs) capable remodeling immune‐microbiota microenvironment via potent anti‐oxidant, anti‐inflammatory, antimicrobial effects is developed. CORM‐401‐loaded mannose‐modified peptide dendrimer nanogel: CMPs preferentially congregate on surface damaged colon mucosa after rectal administration are subsequently internalized by activated cells. CORM‐401 can release numerous molecules response to high ROS levels cells at site IBD, resulting multiple therapeutic In vitro vivo studies have demonstrated that scavenge ROS, suppress responses, eliminate pathogens, alleviate colitis mouse models. RNA sequencing reveals successfully remodel homeostasis scavenging inhibiting NF‐κB/p38MAPK, activating PI3K‐Akt, HIF‐1‐induced glycolysis. 16S ribosomal shows flora composition restraining detrimental bacteria augmenting beneficial bacteria. This study develops promising for management IBD.

Language: Английский

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Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1167 - 1315

Published: Jan. 1, 2024

Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.

Language: Английский

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A Gas Therapy Strategy for Intestinal Flora Regulation and Colitis Treatment by Nanogel‐Based Multistage NO Delivery Microcapsules

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)

Published: Feb. 7, 2024

Current approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, removal reactive intestinal oxygen species, and regulation flora. However, owing complex structure gastrointestinal tract influence mucus, current small-molecule biologic-based drugs for colitis cannot effectively act at site colon inflammation, as a result, they tend exhibit low efficacies toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed achieve release inflammation by targeting tissues using nanogel. Surprisingly, oral administration suppresses growth pathogenic bacteria increases abundance probiotic bacteria. Metabolomics further show that an increased probiotics promotes production metabolites, including short-chain fatty acids indole derivatives, which modulate immunity restore barrier via interleukin-17 PI3K-Akt signaling pathways. This work reveals gas therapy strategy based modulates microbial balance, thereby reducing promoting repair, ultimately providing new therapeutic approach clinical management colitis.

Language: Английский

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The progression of inorganic nanoparticles and natural products for inflammatory bowel disease

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract There is a growing body of evidence indicating close association between inflammatory bowel disease (IBD) and disrupted intestinal homeostasis. Excessive production reactive oxygen species (ROS) nitrogen (RNS), along with an increase in M1 proinflammatory macrophage infiltration during the activation inflammation, plays pivotal role disrupting homeostasis IBD. The overabundance ROS/RNS can cause tissue damage disruption crucial gut proteins, which ultimately compromises integrity barrier. proliferation macrophages contributes to exaggerated immune response, further compromising Currently, nanomaterials have gained widespread attention context IBD due their notable characteristics, including ability specifically target regions interest, clear excess ROS/RNS, mimic biological enzymes. In this review, we initially elucidated microenvironment Subsequently, delineate therapeutic strategies involving two distinct types nanomedicine, namely inorganic nanoparticles natural product nanomaterials. Finally, present comprehensive overview promising prospects associated application nanomedicine future clinical settings for treatment (graphic abstract). Graphical

Language: Английский

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Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 167 - 180

Published: Jan. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Language: Английский

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Mechanism of Nicotiflorin in San-Ye-Qing rhizome for anti-inflammatory effect in ulcerative colitis

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155564 - 155564

Published: March 23, 2024

The incidence of ulcerative colitis (UC) is on the rise globally and development drugs targeting UC urgent. Finding target action natural products important for drug discovery, elucidation mechanism, disease mechanism. San-Ye-Qing (SYQ), an ancient herbal medicine, but whether powder its rhizome has pharmacological effects against mechanism are not clear.

Language: Английский

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