Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: April 1, 2023
Lung
cancer
is
a
common
malignant
tumor
that
occurs
in
the
human
body
and
poses
serious
threat
to
health
quality
of
life.
The
existing
treatment
methods
mainly
include
surgical
treatment,
chemotherapy,
radiotherapy.
However,
due
strong
metastatic
characteristics
lung
emergence
related
drug
resistance
radiation
resistance,
overall
survival
rate
patients
not
ideal.
There
an
urgent
need
develop
new
strategies
or
effective
drugs
treat
cancer.
Ferroptosis,
novel
type
programmed
cell
death,
different
from
traditional
death
pathways
such
as
apoptosis,
necrosis,
pyroptosis
so
on.
It
caused
by
increase
iron-dependent
reactive
oxygen
species
intracellular
iron
overload,
which
leads
accumulation
lipid
peroxides,
thus
inducing
membrane
oxidative
damage,
affecting
normal
life
process
cells,
finally
promoting
ferroptosis.
regulation
ferroptosis
closely
physiological
it
involves
metabolism,
balance
between
oxygen-free
radical
reaction
peroxidation.
A
large
number
studies
have
confirmed
result
combined
action
cellular
oxidation/antioxidant
system
damage/repair,
has
great
potential
application
therapy.
Therefore,
this
review
aims
explore
therapeutic
targets
for
clarifying
regulatory
pathway
Based
on
study
ferroptosis,
mechanism
was
understood
chemical
natural
compounds
targeting
were
summarized,
with
aim
providing
ideas
In
addition,
also
provides
basis
discovery
clinical
effectively
Experimental & Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
55(8), P. 1620 - 1631
Published: Aug. 23, 2023
Abstract
Ferroptosis
is
a
form
of
regulated
cell
death
characterized
by
iron-dependent
lipid
peroxidation.
This
process
contributes
to
cellular
and
tissue
damage
in
various
human
diseases,
such
as
cardiovascular
neurodegeneration,
liver
disease,
cancer.
Although
polyunsaturated
fatty
acids
(PUFAs)
membrane
phospholipids
are
preferentially
oxidized,
saturated/monounsaturated
(SFAs/MUFAs)
also
influence
peroxidation
ferroptosis.
In
this
review,
we
first
explain
how
cells
differentially
synthesize
SFA/MUFAs
PUFAs
they
control
acid
pools
via
uptake
β-oxidation,
impacting
Furthermore,
discuss
stored
different
lipids,
diacyl
or
ether
with
head
groups;
triglycerides;
cholesterols.
Moreover,
these
released
from
molecules.
summary,
provide
an
integrated
view
the
diverse
dynamic
metabolic
processes
context
ferroptosis
revisiting
lipidomic
studies.
Thus,
review
development
therapeutic
strategies
for
ferroptosis-related
diseases.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: June 6, 2024
Abstract
Ferroptosis,
an
iron-dependent
form
of
cell
death
characterized
by
uncontrolled
lipid
peroxidation,
is
governed
molecular
networks
involving
diverse
molecules
and
organelles.
Since
its
recognition
as
a
non-apoptotic
pathway
in
2012,
ferroptosis
has
emerged
crucial
mechanism
numerous
physiological
pathological
contexts,
leading
to
significant
therapeutic
advancements
across
wide
range
diseases.
This
review
summarizes
the
fundamental
mechanisms
regulatory
pathways
underlying
ferroptosis,
including
both
GPX4-dependent
-independent
antioxidant
mechanisms.
Additionally,
we
examine
involvement
various
conditions,
cancer,
neurodegenerative
diseases,
sepsis,
ischemia–reperfusion
injury,
autoimmune
disorders,
metabolic
disorders.
Specifically,
explore
role
response
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy,
targeted
therapy.
Furthermore,
discuss
pharmacological
strategies
for
modulating
potential
biomarkers
monitoring
this
process.
Lastly,
elucidate
interplay
between
other
forms
regulated
death.
Such
insights
hold
promise
advancing
our
understanding
context
human
health
disease.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: April 1, 2023
Lung
cancer
is
a
common
malignant
tumor
that
occurs
in
the
human
body
and
poses
serious
threat
to
health
quality
of
life.
The
existing
treatment
methods
mainly
include
surgical
treatment,
chemotherapy,
radiotherapy.
However,
due
strong
metastatic
characteristics
lung
emergence
related
drug
resistance
radiation
resistance,
overall
survival
rate
patients
not
ideal.
There
an
urgent
need
develop
new
strategies
or
effective
drugs
treat
cancer.
Ferroptosis,
novel
type
programmed
cell
death,
different
from
traditional
death
pathways
such
as
apoptosis,
necrosis,
pyroptosis
so
on.
It
caused
by
increase
iron-dependent
reactive
oxygen
species
intracellular
iron
overload,
which
leads
accumulation
lipid
peroxides,
thus
inducing
membrane
oxidative
damage,
affecting
normal
life
process
cells,
finally
promoting
ferroptosis.
regulation
ferroptosis
closely
physiological
it
involves
metabolism,
balance
between
oxygen-free
radical
reaction
peroxidation.
A
large
number
studies
have
confirmed
result
combined
action
cellular
oxidation/antioxidant
system
damage/repair,
has
great
potential
application
therapy.
Therefore,
this
review
aims
explore
therapeutic
targets
for
clarifying
regulatory
pathway
Based
on
study
ferroptosis,
mechanism
was
understood
chemical
natural
compounds
targeting
were
summarized,
with
aim
providing
ideas
In
addition,
also
provides
basis
discovery
clinical
effectively
