Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 536 - 545
Published: Jan. 1, 2025
Language: Английский
Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Language: Английский
Citations
4
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103259 - 103259
Published: June 27, 2024
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins. These undergo precise control through diverse post-translational modifications, including ubiquitination, phosphorylation, acetylation, O-GlcNAcylation, SUMOylation, methylation, N-myristoylation, palmitoylation, modification. modifications play pivotal roles in regulating protein stability, activity, localization, interactions, ultimately influencing both the buildup iron lipid peroxidation. In mammalian cells, regulators ferroptosis typically degradation via two principal pathways: ubiquitin-proteasome which handles majority degradation, autophagy, primarily targeting long-lived or aggregated This comprehensive review aims to summarize recent advances modification linked ferroptosis. It also discusses strategies for modulating systems, providing new insights into potential therapeutic applications cancer non-neoplastic diseases.
Language: Английский
Citations
16
Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)
Published: Nov. 30, 2024
Abstract Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since discovery in 2012, extensive research has demonstrated pivotal roles tumorigenesis, metastasis cancer therapy. The tumor microenvironment (TME) complex ecosystem comprising cells, non-cancer extracellular matrix, metabolites cytokines. Recent studies have underscored new paradigm which cells the TME, such as immune stromal also play significant regulating progression therapeutic resistance typically through complicated crosstalk with cells. Notably, this TME were partially mediated ferrotopsis-related mechanisms. This review provides comprehensive systematic summary current findings concerning ferroptosis how ferroptosis-mediated reprogramming impacts progression. Additionally, outlines various ferroptosis-related strategies aimed at targeting TME.
Language: Английский
Citations
10
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 201 - 201
Published: March 18, 2025
Among the most common malignant tumors, hepatocellular carcinoma (HCC) is a primary liver cancer type that has high mortality rate. HCC often presents insidiously, prone to recurrence, and limited treatment efficacy. Ferroptosis regulates tumorigenesis, progression, metastasis, which novel form of iron-dependent cell death. Numerous studies suggest sensitive ferroptosis, indicating targeted therapies aimed at inducing ferroptosis may represent promising new approach treatment. This study aims find genes associated with as well screen for potential agents cause in HCC. Transcriptome clinical sample data were obtained from TCGA database identify differentially expressed related ferroptosis. Using various regression survival analysis techniques, we developed prognostic model based on four core evaluated its predictive potential. Subsequently, screened therapeutic Connective Map (CMap) database, designated compound Atorvastatin, differential two risk groups Through experiments conducted vivo vitro, demonstrated Atorvastatin can induce cells while inhibiting their growth migration. In conclusion, this research targets therapy provides insights improving prediction prevention
Language: Английский
Citations
2
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 20, 2024
Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid peroxidation in membrane phospholipids. Since its identification 2012, extensive research has unveiled involvement the pathophysiology numerous diseases, including cancers, neurodegenerative disorders, organ injuries, infectious autoimmune conditions, metabolic and skin diseases. Oxidizable lipids, overload iron, compromised antioxidant systems are known as critical prerequisites for driving overwhelming peroxidation, ultimately leading to plasma rupture ferroptotic death. However, precise regulatory networks governing ferroptosis ferroptosis-targeted therapy these diseases remain largely undefined, hindering development pharmacological agonists antagonists. In this review, we first elucidate core mechanisms summarize epigenetic modifications (e.g., histone modifications, DNA methylation, noncoding RNAs, N6-methyladenosine modification) nonepigenetic genetic mutations, transcriptional regulation, posttranslational modifications). We then discuss association between disease pathogenesis explore therapeutic approaches targeting ferroptosis. also introduce potential clinical monitoring strategies Finally, put forward several unresolved issues which progress needed better understand hope review will offer promise application therapies context human health disease.
Language: Английский
Citations
9
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156232 - 156232
Published: Nov. 15, 2024
JinWu JianGu capsule (JWJGC) is a Chinese herbal medicine that alleviates the clinical manifestations of rheumatoid arthritis (RA). However, mechanism action requires further investigation..
Language: Английский
Citations
8
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 265 - 265
Published: Jan. 22, 2025
Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked significant therapeutic gaps high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis disease pathogenesis, focusing on its role oxidative damage neuronal dysfunction. We explore recent pharmacological advancements, including chelators, peroxidation blockers, antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, such heterogeneity, limited diagnostic tools, small patient cohorts hinder progress. Furthermore, we discuss translational regulatory barriers implementing ferroptosis-based therapies clinical practice. By addressing obstacles fostering innovative solutions, this underscores potential ferroptosis-targeting strategies revolutionize treatment paradigms
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114341 - 114341
Published: March 1, 2025
Language: Английский
Citations
1
Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)
Published: Feb. 17, 2025
Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine and metabolic disorder in women, with an incidence rate of 10-13%. The etiology PCOS multifaceted, involving genetic predisposition, environmental influences, lifestyle factors, dysregulation. Iron, critical mineral, not only plays role regulating female physiological functions the progression but also requires careful management to avoid deficiency. However, excess iron can trigger ferroptosis, form nonapoptotic cell death characterized by accumulation lipid peroxides. While numerous studies have explored ferroptosis patients animal models, precise mechanisms therapeutic implications remain inadequately understood. This review seeks elucidate pathophysiology contributory factors ferroptosis. Additionally, we examine diverse manifestations evaluate its role. Furthermore, introduce ferroptosis-related traditional Chinese medicines that may enhance understanding pathogenesis aid development targeted therapies for PCOS.
Language: Английский
Citations
1
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 3, 2025
Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.
Language: Английский
Citations
1