Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease DOI Open Access

Dexiang Xia,

Qinwen Zheng,

Yue Liu

et al.

Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally. Recent groundbreaking preclinical clinical research underscores the pivotal role metabolite remodelling in pathology CVD. This metabolic transformation not only directly fuels progression CVD but also profoundly influences immune response within cardiovascular system. In this review, we focused on complex interactions between alterations responses during course Furthermore, explore potential therapeutic interventions that could be developed based understanding dysregulation By targeting these immunological pathways, novel strategies for prevention treatment CVDs might to improve patient outcomes reduce global burden disease.

Language: Английский

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism DOI Creative Commons
Federica Danzi,

Raffaella Pacchiana,

Andrea Mafficini

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 22, 2023

Abstract Tumour cells have exquisite flexibility in reprogramming their metabolism order to support tumour initiation, progression, metastasis and resistance therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosynthetic redox status sustain increased energetic demand cells. Over last decades, cancer field has seen an explosion new biochemical technologies giving more tools than ever before navigate this complexity. Within cell or tissue, metabolites constitute direct signature molecular phenotype thus profiling concrete clinical applications oncology. Metabolomics fluxomics, are key technological approaches that mainly revolutionized enabling researchers both qualitative mechanistic model cancer. Furthermore, upgrade from bulk single-cell analysis provided unprecedented opportunity investigate biology at cellular resolution allowing depth quantitative complex heterogenous diseases. More recently, advent functional genomic screening allowed identification pathways, processes, biomarkers novel therapeutic targets concert with other allow patient stratification treatment regimens. This review is intended be guide for metabolism, highlighting current emerging technologies, emphasizing advantages, disadvantages potential leading development innovative anti-cancer

Language: Английский

Citations

111
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations DOI
Lisa H. Butterfield, Yana G. Najjar

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 24(6), P. 399 - 416

Published: Dec. 6, 2023

Language: Английский

Citations

103
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells DOI Creative Commons
Theresa Ramalho, Patrícia A. Assis,

Ogooluwa Ojelabi

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(3), P. 484 - 497.e6

Published: Feb. 6, 2024

Severe forms of malaria are associated with systemic inflammation and host metabolism disorders; however, the interplay between these outcomes is poorly understood. Using a Plasmodium chabaudi model malaria, we demonstrate that interferon (IFN) γ boosts glycolysis in splenic monocyte-derived dendritic cells (MODCs), leading to itaconate accumulation disruption TCA cycle. Increased levels reduce mitochondrial functionality, which associates organellar nucleic acid release MODC restraint. We hypothesize dysfunctional mitochondria degraded DNA into cytosol. Once sensitized, activation IRF3 IRF7 promotes expression IFN-stimulated genes checkpoint markers. Indeed, depletion STING-IRF3/IRF7 axis reduces PD-L1 expression, enabling CD8+ T control parasite proliferation. In summary, caused by MODCs leads suppressive effect cells, enhances parasitemia. provide evidence ACOD1 potential targets for adjunct antimalarial therapy.

Language: Английский

Citations

29
Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases DOI Creative Commons
Carolina Ferreira, Pedro Vieira, Susana Machado

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune non-autoimmune mediated. The immune system regulates functioning cellular within organs like brain, pancreas and/or adipose tissue by sensing adapting to fluctuations microenvironment’s nutrients, thereby reshaping metabolic pathways that greatly impact pro- or anti-inflammatory immunophenotype. While it is agreed relies on an adequate nutritional status function properly, we are only just starting understand how supply single combined all them termed immunonutrients, can steer cells towards less inflamed, tolerogenic Polyphenols, class secondary metabolites abundant Mediterranean foods, pharmacologically active natural products with outstanding immunomodulatory actions. Upon binding range receptors highly expressed (e.g. AhR, RAR, RLR), they act through mitochondria-centered multi-modal approach. First , polyphenols activate nutrient via stress-response pathways, essential for responses. Second regulate mammalian target rapamycin (mTOR)/AMP-activated protein kinase (AMPK) balance well-tolerated caloric restriction mimetics. Third interfere assembly NLR family pyrin domain containing 3 (NLRP3) endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis autophagosome-lysosome fusion. Finally chromatin remodeling coordinates epigenetic reprogramming. This work moves beyond well-documented antioxidant properties polyphenols, offering new insights into multifaceted nature these compounds. It proposes mechanistical appraisal regulatory which modulate response, alleviating low-grade inflammation. Furthermore, draws parallels pharmacological interventions polyphenol-based immunonutrition their modes immunomodulation across spectrum socioeconomically impactful diseases such as Multiple Sclerosis, Diabetes (type 1 2) even Alzheimer’s disease. Lastly, discusses existing challenges thwart translation polyphenols-based immunonutritional long-term clinical studies. Overcoming limitations will undoubtedly pave way precision nutrition protocols provide personalized guidance tailored plans.

Language: Английский

Citations

25
MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma DOI Creative Commons

Camille Niveau,

Mélanie Cettour-Cave,

Stéphane Mouret

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 27, 2025

Language: Английский

Citations

2
Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of Multiple Sclerosis DOI Creative Commons
Insha Zahoor,

Mohammad Nematullah,

Mohammad Ejaz Ahmed

et al.

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108226 - 108226

Published: Jan. 1, 2025

Language: Английский

Citations

2
Strategies to overcome DC dysregulation in the tumor microenvironment DOI Creative Commons
Guillaume Mestrallet,

Kazuki Sone,

Nina Bhardwaj

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor microenvironment (TME). They link innate adaptive by processing and presenting antigens T thereby initiating an anti-tumor response. However, subsets of DCs also induce immune-tolerance, leading immune escape. In this regard, TME plays major adversely affecting DC function. Better understanding impairment mechanisms will lead more efficient DC-targeting immunotherapy. Here, we review different subtypes functions TME, including conventional DCs, plasmacytoid newly proposed subset, mregDC. We further focus on how cancer escape from host’s immune-surveillance. Immune checkpoint expression, small molecule mediators, metabolites, deprivation pro-immunogenic release pro-tumorigenic cytokine secretion tumors tumor-attracted immuno-suppressive inhibit differentiation Finally, discuss impact established therapies such as blockade. Creative DC-targeted therapeutic strategies be highlighted, vaccines cell-based therapies.

Language: Английский

Citations

40
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis DOI
J. Tucker Andrews, Zijing Zhang, Gauri Prasad

et al.

Mucosal Immunology, Journal Year: 2024, Volume and Issue: 17(5), P. 825 - 842

Published: June 5, 2024

Language: Английский

Citations

15
The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity DOI Creative Commons
Beata Pająk, Rafał Zieliński, Waldemar Priebe

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1298 - 1298

Published: March 14, 2024

Glucose metabolism is a crucial biological pathway maintaining the activation of extra- and intracellular signaling pathways involved in immune response. Immune cell stimulation via various environmental factors results their metabolic reprogramming to aerobic glycolysis. Different cells exhibit cell-type-specific patterns when performing functions. Numerous published studies have shed more light on importance system. Moreover, this knowledge for revealing new ways target inflammatory pathologic states, such as autoimmunity hyperinflammation. Here, we discuss role glycolysis activity physiological pathological conditions, potential use inhibitors disease treatment.

Language: Английский

Citations

12
Dendritic cell subsets and implications for cancer immunotherapy DOI Creative Commons
Michael Y. Chen, Felicia Zhang, S. Peter Goedegebuure

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 5, 2024

Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory milieu all impact DCs with regard to promoting or inhibiting tumor immunity. The following review introduces important facets function, how subset phenotype can affect interplay other factors microenvironment. It will also discuss current cancer treatment relies on survey myriad ways which immune therapy more directly harness enact antitumor cytotoxicity.

Language: Английский

Citations

10