Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 19, 2024
Existing
methods
for
studying
neural
circuits
and
treating
neurological
disorders
are
typically
based
on
physical
chemical
cues
to
manipulate
record
activities.
These
approaches
often
involve
predefined,
rigid,
unchangeable
signal
patterns,
which
cannot
be
adjusted
in
real
time
according
the
patient's
condition
or
With
continuous
development
of
interfaces,
conducting
vivo
research
adaptive
modifiable
treatments
diseases
is
now
possible.
In
this
review,
current
potential
integration
various
modalities
achieve
precise,
closed-loop
modulation,
sensing
systems
summarized.
Advanced
materials,
devices,
that
generate
detect
electrical,
magnetic,
optical,
acoustic,
signals
highlighted
utilized
interact
with
cells,
tissues,
networks
interrogation.
Further,
significance
developing
techniques
diagnostics
treatment
such
as
epilepsy,
depression,
rehabilitation
spinal
cord
injury
patients,
exploration
brain
circuit
functionality
elaborated.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 4, 2023
The
concept
of
targeted
and
controlled
drug
delivery,
which
directs
treatment
to
precise
anatomical
sites,
offers
benefits
such
as
fewer
side
effects,
reduced
toxicity,
optimized
dosages,
quicker
responses.
However,
challenges
remain
engineer
dependable
systems
materials
that
can
modulate
host
tissue
interactions
overcome
biological
barriers.
To
stay
aligned
with
advancements
in
healthcare
precision
medicine,
novel
approaches
are
imperative
improve
effectiveness,
biocompatibility,
compliance.
Electronically
delivery
(ECDD)
has
recently
emerged
a
promising
approach
calibrated
spatial
temporal
precision.
This
article
covers
recent
breakthroughs
soft,
flexible,
adaptable
bioelectronic
micro-systems
designed
for
ECDD.
It
overviews
the
most
widely
reported
operational
modes,
engineering
strategies,
electronic
interfaces,
characterization
techniques
associated
ECDD
systems.
Further,
it
delves
into
pivotal
applications
wearable,
ingestible,
implantable
medical
devices.
Finally,
discourse
extends
future
prospects
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: July 27, 2023
Although
multifunctional
wearable
devices
have
been
widely
investigated
for
healthcare
systems,
augmented/virtual
realities,
and
telemedicines,
there
are
few
reports
on
multiple
signal
monitoring
logical
processing
by
using
one
single
nanomaterial
without
additional
algorithms
or
rigid
application-specific
integrated
circuit
chips.
Here,
intelligent
developed
monolithically
patterned
gold
nanowires
both
processing.
Gold
bulk
hollow
show
distinctive
electrical
properties
with
high
chemical
stability
stretchability.
In
accordance,
the
can
be
used
to
fabricate
robust
interfaces,
programmable
sensors,
on-demand
heating
strain-gated
circuits.
The
stretchable
sensors
sensitivity
strain
temperature
changes
skin.
Furthermore,
micro-wrinkle
structures
of
exhibit
negative
gauge
factor,
which
Taken
together,
this
device
would
harnessed
as
a
promising
platform
futuristic
electronic
biomedical
applications.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Microfluidics,
the
science
and
technology
of
manipulating
fluids
in
microscale
channels,
offers
numerous
advantages,
such
as
low
energy
consumption,
compact
device
size,
precise
control,
fast
reaction,
enhanced
portability.
These
benefits
have
led
to
applications
biomedical
assays,
disease
diagnostics,
drug
discovery,
neuroscience,
so
on.
Fluid
flow
within
microfluidic
channels
is
typically
laminar
region,
which
characterized
by
Reynolds
numbers
but
brings
challenge
efficient
mixing
fluids.
Periodic
flows
are
time‐dependent
fluid
flows,
featuring
repetitive
patterns
that
can
significantly
improve
extend
effective
length
microchannels
for
submicron
nanoparticle
manipulation.
Besides,
periodic
crucial
organ‐on‐a‐chip
(OoC)
accurately
modeling
physiological
processes,
advancing
understanding,
development,
personalized
medicine.
Various
techniques
generating
been
reported,
including
syringe
pumps,
peristalsis,
actuation
based
on
electric,
magnetic,
acoustic,
mechanical,
pneumatic,
fluidic
forces,
yet
comprehensive
reviews
this
topic
remain
limited.
This
paper
aims
provide
a
review
microfluidics,
from
fundamental
mechanisms
generation
applications.
The
challenges
future
perspectives
also
discussed
exploit
potential
microfluidics.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(8)
Published: Dec. 9, 2022
Future
electronic
skin
systems
require
stretchable
conductors
and
low-temperature
integration
of
external
components,
which
remains
challenging
for
traditional
metal
films.
Herein,
a
bioinspired
design
concept
is
reported
to
endow
films
with
200%
stretchability
as
well
room-temperature
capability
diverse
components.
It
revealed
that
by
controllable
implantation
defects,
distinctive
venation-mimicking
cracking
modes
can
be
induced
in
strained
films,
leading
profound
regulation.
An
intriguing
exponential-to-linear
transition
the
film
electromechanical
performance
observed,
elucidated
unified
model
covering
essence
all
modes.
Combined
capability,
an
integrated
constructed
serving
electrodes,
sensors,
"tapes"
attach
subcomponents,
showing
prospects
helping
disabled
people.
This
one-step,
defect
strategy
applicable
common
metals
without
special
substrate
treatments,
enables
fascinating
ultrastretchable
spark
more
sophisticated
flexible
systems.
Soft Science,
Journal Year:
2024,
Volume and Issue:
4(1)
Published: Feb. 21, 2024
Recent
advancements
in
materials
and
mechanics
have
paved
the
way
for
transforming
rigid
circuits
into
flexible
electronics.
Their
ability
to
laminate
onto
skin
has
led
development
of
skin-interfaced
electronics,
including
mechano-acoustic
sensors
haptic
systems.
However,
challenges
coupled
between
electronics
call
further
understanding
biomechanics,
bioelectronics,
their
interactions.
This
perspective
article
highlights
emerging
trend
employing
computer
vision
methods
optimize
next
generation
by
characterizing
associated
biomechanics
vice
versa.
The
cyclic
research
process
involves
soft
identification
mechanics,
quantification
using
methods.
describes
state-of-the-art
techniques
context
potential
applications
other
forms
Giant,
Journal Year:
2024,
Volume and Issue:
18, P. 100272 - 100272
Published: April 26, 2024
Electrophysiology
and
optogenetics
are
pivotal
in
neuroscience
for
probing
modulating
neural
activities,
playing
a
vital
role
unraveling
the
complexities
of
brain
functionality.
Despite
their
importance,
efficacy
existing
devices
is
hampered
by
insufficient
functional
integration,
pronounced
foreign
body
reactions,
physical
constraints
that
impede
natural
animal
behaviors.
Here,
we
develop
multifunctional,
ultraflexible
probe
designed
simultaneous
electrophysiological
monitoring
optical
modulation,
along
with
mechanical
properties
conducive
to
flexibility
compliance.
By
integrating
wireless
signal
acquisition
stimulation
circuit,
achieved
recording
signals
mice
optogenetic
control
over
locomotor
behavior.
The
multifunctional
presented
this
study
holds
substantial
promise
closed-loop
brain-machine
interfaces
deepening
our
understanding
circuit
functions.
This
innovative
approach
addresses
aforementioned
limitations
comprehensive
solution
vivo
interrogation
manipulation,
marking
significant
advancement
tools
available
research.
Medicinal Research Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 5, 2025
ABSTRACT
Photopharmacology
is
an
innovative
approach
that
uses
light
to
activate
drugs.
This
method
offers
the
potential
for
highly
localized
and
precise
drug
activation,
making
it
particularly
promising
treatment
of
neurological
disorders.
Despite
enticing
prospects
photopharmacology,
its
application
treat
human
central
nervous
system
(CNS)
diseases
remains
be
demonstrated.
In
this
review,
we
provide
overview
prominent
strategies
design
activation
photopharmaceutical
agents
in
field
neuroscience.
Photocaged
photoswitchable
drugs
bioactive
molecules
are
discussed,
instructive
list
examples
provided
highlight
compound
strategies.
Special
emphasis
placed
on
photoactivatable
compounds
modulation
glutamatergic,
GABAergic,
dopaminergic,
serotonergic
neurotransmission
conditions,
as
well
various
photoresponsive
with
improved
pain
management.
Compounds
holding
promise
clinical
translation
discussed
in‐depth
their
future
applications
assessed.
Neurophotopharmaceuticals
have
yet
achieve
breakthrough
clinic,
both
delivery
not
reached
full
maturity.
However,
by
describing
current
state
art
providing
illustrative
case
studies,
offer
a
perspective
opportunities
neurophotopharmacology
focused
addressing
CNS
