Advances in Gas Therapeutics for Wound Healing: Mechanisms, Delivery Materials, and Prospects

Small Structures, Journal Year: 2023, Volume and Issue: 5(1)

Published: Sept. 27, 2023

Wound repair, particularly chronic nonhealing wound is a global health issue that affects millions of people worldwide. As an effective and safe therapeutic reagent, gas molecules in tissue repair have attracted considerable attention. Recent studies shown therapy (GT) plays essential role all phases including anti‐inflammatory antimicrobial modulation, cell proliferation migration, proangiogenesis, extracellular matrix remodeling. This review aims to summarize recent progress developing GT for repair. The characteristics with functions, such as oxygen, nitric oxide, carbon monoxide, hydrogen sulfide, others (such sulfur dioxide, hydrogen, plasma) healing are introduced. has transitioned from pure gases inorganic/organic materials gas‐releasing materials, gas‐producing gas‐loaded controlled/long‐lasting stable‐releasing biomaterials. Finally, the limitations prospects field analyzed summarized.

Language: Английский

---

Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of Wound Healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101093 - 101093

Published: May 18, 2024

The incidence of chronic wound healing is promoted by the growing trend elderly population, obesity, and type II diabetes. Although numerous dressings have been studied over years, it still challenging for many to perfectly adapt process due dynamic complicated microenvironment. Aiming at an optimal reproduction physiological environment, multifunctional electrospinning nanofibrous membranes (ENMs) emerged as a promising platform treatment owing their resemblance extracellular matrix (ECM), adjustable preparation processes, porousness, good conformability site. Moreover, profiting from booming development human-machine interaction artificial intelligence, next generation intelligent (iENMs) based dressing substrates that could realize real-time monitoring proceeding individual-based therapy has evoked surge interest. In this regard, general wound-related biomarkers are overviewed firstly representative iENMs stimuli-responsive materials briefly summarized. Subsequently, emergent applications highlighted. Finally, opportunities challenges next-generation well translating into clinical practice evaluated.

Language: Английский

---

Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 374 - 383

Published: May 10, 2024

Implant-related osteomyelitis is a formidable hurdle in the clinical setting and characterized by inflammation, infection, consequential bone destruction. Therefore, effective reactive oxygen species (ROS) scavenging, bacterial killing, subsequent tissue repair are urgently needed for treatment of difficult-to-heal osteomyelitis. Herein, we utilized eddy-thermal effect magnesium (Mg) implants under an alternating magnetic field (AMF) controlled release H

Language: Английский

---

Multifunctional gold clusterzymes with distinct glucose depletion and macrophage reprogramming capability towards regulating the regeneration cascade

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 149068 - 149068

Published: Jan. 1, 2024

Language: Английский

---

Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(3), P. 365 - 383

Published: Jan. 1, 2024

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding supporting future drug delivery system development.

Language: Английский

---

Ultra-high antioxidant, anti-apoptosis and pro-angiogenesis effect of Mo2C nanosheets for treatment of diabetic wounds

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102202 - 102202

Published: Feb. 15, 2024

Language: Английский

---

A modified hyaluronic acid hydrogel with strong bacterial capture and killing capabilities for drug-resistant bacteria-infected diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135301 - 135301

Published: Sept. 3, 2024

Language: Английский

---

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS‐STING Activation for Bidirectional Synergistic Hydrogen‐Immunotherapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract The cGAS‐STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of pathway. Herein, Mn galvanic cells (MnG) are prepared via liquid‐phase exfoliation and situ replacement to modulate thereby enhancing for bidirectional synergistic H 2 ‐immunotherapy. obtained MnG can be etched by water, enabling efficient sustained generation gas 2+ . not only activated amplified through release but also regulated glucose metabolism inhibit expression three prime repair exonuclease (TREX2), synergistically injection into tumors resulted a robust immune response, providing favorable support therapy. Consequently, combination with checkpoint blockade therapy significant suppression both primary distant tumors. Furthermore, MnG‐lipiodol dispersion exhibited remarkable efficacy transarterial embolization (TAE)‐gas‐immunotherapy rabbit orthotopic liver model. present study underscores significance employing metal cell strategy enhanced immunotherapy, offering novel approach rational design bioactive materials augment immunotherapeutic effectiveness.

Language: Английский

---

Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 30, 2025

Language: Английский

---

Glucose‐Activated Programmed Hydrogel with Self‐Switchable Enzyme‐Like Activity for Infected Diabetic Wound Self‐Adaptive Treatment

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract The defective blood glucose regulation ability of diabetic patients leading to bacterial infection, cellular oxidative stress, and vascular damage results in delayed healing chronic wounds. Here, a glucose‐activated self‐switching enzyme‐like activity programmed hydrogel is proposed provide self‐regulated timely intelligent insulin release affected by fluctuations, thereby forming feedback management exerting full‐stage wound healing. composed Au─MoS 2 ─phenylboronic acid nanozyme insulin‐loaded nitroimidazole‐modified sodium alginate hypoxia‐sensitive microcapsules penylboronic‐acid‐modified chitosan. It utilizes as sacrificial agent generate antibacterial reactive oxygen species recognizing the hyperglycemia environment, releasing for up 12 h with help catalysis‐generated hypoxia environment. In normoglycemia switches supply oxygen, inhibiting further release. achieves ≈3 times recovery rate commercial dressings through improved microenvironment. has been proven significantly improve wounds regulating body's homeostasis implementing staged treatment plan, providing powerful solution care.

Language: Английский

---