The cellular lives of Wolbachia

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(11), P. 750 - 766

Published: July 10, 2023

Language: Английский

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Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima

Applied and Environmental Microbiology, Journal Year: 2023, Volume and Issue: unknown

Published: April 26, 2023

Many microbes induce male killing (MK) in various insect species. However, it is not well understood whether adopt similar or different MK mechanisms.

Language: Английский

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Wolbachia-based strategies for control of agricultural pests

Current Opinion in Insect Science, Journal Year: 2023, Volume and Issue: 57, P. 101039 - 101039

Published: April 25, 2023

Language: Английский

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Endosymbionts as hidden players in tripartite pathosystem of interactions and potential candidates for sustainable viral disease management

Critical Reviews in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: Jan. 23, 2025

The convoluted relationships between plants, viruses, and arthropod vectors housing bacterial endosymbionts are pivotal in the spread of harmful plant viral diseases. Endosymbionts play key roles in: manipulating host responses, influencing insect resistance to pesticides, shaping evolution, bolstering virus acquisition, retention, transmission. This interplay presents an innovative approach for developing sustainable strategies manage Recent progress targeting specific through genetic modifications, biotechnological advancements, RNA interference shows potential curbing disease progression. Additionally, employing synthetic biology techniques like CRISPR/Cas9 engineer disrupt crucial interactions necessary transmission holds promise effective control measures. In this review, these obligate facultative cruxes have been discussed elaborate on their mechanistic involvement regulation and/or inhibition tripartite pathways interactions. Furthermore, we provide in-depth understanding endosymbionts' synergistic antagonistic effects on: biology, immunity, acquisition Finally, point out open questions future research directions concerning deployment genetically engineered symbionts affect plant-virus-vector management. By addressing existing knowledge gaps charting paths, a deeper comprehension role can pave way successful management strategies. exploration antiviral therapies, paratransgenesis, pathogen-blocking tactics using introduces pioneering solutions lessening impact diseases green pest

Language: Английский

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A Wolbachia strain in the flour moth, Ephestia kuehniella, causes moderate cytoplasmic incompatibility but has little impact on host fitness

Journal of Stored Products Research, Journal Year: 2025, Volume and Issue: 111, P. 102577 - 102577

Published: Feb. 17, 2025

Language: Английский

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Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima

Published: March 13, 2025

Wolbachia are maternally transmitted bacterial symbionts that ubiquitous among arthropods. They can hijack host reproduction in various ways, including male killing (MK), where the sons of infected mothers killed during development. The recent discovery MK-associated genes, i.e., oscar Ostrinia moths and wmk Drosophila flies, stimulates our interest diversity commonality MK mechanisms, which remain largely unclear. We recently discovered a symbiont moth Homona magnanima carries an prophage region encoding homologs ( Hm-oscar ) wmk- 1–4). Here, we investigated effects these genes native host. Upon transient overexpression, , but not induced lethality H. contrast to observations homologs, males. disrupted sex determination embryos by inducing female-type doublesex splicing impaired dosage compensation, recapitulating phenotype. Cell-based transfection assays confirmed suppressed function masculinizer primary determinant involved lepidopteran compensation. Our study highlights conserved roles -induced argues have evolved multiple mechanisms insects.

Language: Английский

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Evolution of Wolbachia male-killing mechanism within a host species

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Combined actions of bacteriophage-encoded genes in Wolbachia-induced male lethality

iScience, Journal Year: 2023, Volume and Issue: 26(6), P. 106842 - 106842

Published: May 11, 2023

Some

Language: Английский

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Two male-killing Wolbachia from Drosophila birauraia that are closely related but distinct in genome structure

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 1, 2024

Insects harbour diverse maternally inherited bacteria and viruses, some of which have evolved to kill the male progeny their hosts (male killing: MK). The fly species

Language: Английский

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Zygosity-based sex determination in a butterfly drives hypervariability of Masculinizer

Science Advances, Journal Year: 2024, Volume and Issue: 10(18)

Published: May 3, 2024

Nature has devised many ways of producing males and females. Here, we report on a previously undescribed mechanism for Lepidoptera that functions without female-specific gene. The number alleles or allele heterozygosity in single Z-linked gene ( BaMasc ) is the primary sex-determining switch Bicyclus anynana butterflies. Embryos carrying develop into WZ (or Z0) females, those two distinct ZZ males, while (ZZ) homozygotes initiate female development, have mismatched dosage compensation, die as embryos. Consequently, selection against favored evolution spectacular allelic diversity: 205 different coding sequences were detected sample 246 structural similarity hypervariable region (HVR) to HVR Apis mellifera csd suggests molecular convergence between deeply diverged insect lineages. Our discovery this highlights fascinating diversity mechanisms underlying evolutionary drivers.

Language: Английский

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