iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109977 - 109977
Published: May 14, 2024
Language: Английский
Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(28), P. 5241 - 5250
Published: June 26, 2023
Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short increases risk of lower brain health and cognitive function. Chronic mild deprivation could cause undetected debt, negatively affecting function health. However, it is possible that some have need are more resistant negative effects loss. We investigated this using a cross-sectional longitudinal sample 47,029 participants both sexes (20-89 years) from the Lifebrain consortium, Human Connectome project (HCP) UK Biobank (UKB), with measures self-reported sleep, including 51,295 MRIs tests. A total 740 who reported <6 h did not experience sleepiness or problems/disturbances interfering falling staying asleep. These sleepers showed significantly larger regional volumes problems (
Language: Английский
Citations
12
Vertex Revista Argentina de Psiquiatría, Journal Year: 2025, Volume and Issue: 35(166), P. 20 - 28
Published: Jan. 10, 2025
evaluar la calidad, hábitos y algunos trastornos del sueño días previos a declaración fin de pandemia por COVID-19. Método: estudio observacional corte transversal. Encuesta en línea distribuida través una plataforma web desde el 1 marzo al 15 abril 2023. El análisis consideró: información demográfica, calidad cambios hábitos/conductas. se evaluaron N=2081 respuestas. La edad media fue 37 ± 12 (16-86 años). 56,5 % las respuestas fueron Área Metropolitana Buenos Aires 70,7 eran mujeres. 68,3 presentaba mala sueño. 31,8 dormía con mascotas. 44,2% refirió conciliación 34,9% que menos seis horas. 25,5 eficiencia su era inferior 75%. Refirieron alteraciones mantenimiento 25,3 %; ronquidos pesadillas 16.4 bruxismo 20.4 síndrome piernas inquietas 14.8 %. asoció sexo femenino (p=0,00), los residían (p=0,01) dormían mascotas (p=0,00). presentó mayor prevalencia síntomas identificó más mitad población principalmente mujeres, residentes área metropolitana quienes
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317026 - e0317026
Published: Jan. 27, 2025
Virtual reality environments presented on tablets and smartphones offer a novel way of measuring navigation skill predicting real-world problems. The extent to which such virtual tests are effective at in older populations remains unclear. We compared the performance 20 participants (54–74 years old) wayfinding tasks environment London, UK, similar designed mobile app-based test (Sea Hero Quest). In previous study with young (18–35 old), we were able predict London Paris using this app. find that for cohort, predicts medium difficulty, but not easy or difficult environments. Overall, our supports utility digital spatial cognition age groups, while carefully adapting task difficulty population.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Sleep disruptions precede a clinical diagnosis of Alzheimer’s disease (AD) by several years. However, how AD pathologies affect sleep remains unclear. Here, we integrate epidemiological data with insights from Drosophila models to investigate progression could be linked disruption. We found that individuals high risk report shorter duration than do those AD. showed the expression different forms amyloid-β in flies can replicate these variations duration. Analysis metabolome and proteome revealed distinct changes NAD + -linked redox metabolism levels hyperkinetic (Hk), redox-sensing homeostat. genetic upregulation Hk is neuroprotective increased KCNAB2 brain decreases humans. Overall, our provides new mechanism linking disruption sensing
Language: Английский
Citations
0
Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Language: Английский
Citations
0
Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)
Published: March 25, 2025
This study compares sleep duration and stroke risk between residents of China the U.S. during outside COVID-19 pandemic, examining age as an interaction effect. analyzed data from National Health Nutrition Examination Survey (NHANES) Retirement Longitudinal Study (CHARLS). A total 9131 American adults participated 2017 to March 2020, 7678 August 2021 2023. In China, 13,514 in 2018 9441 2020. Stroke incidence was assessed via survey responses, with "yes" indicating a history stroke. Participants were categorized by age, multivariable logistic regression analyses evaluated effects, supported subgroup sensitivity analyses. Restricted cubic splines (RCS) examined nonlinear associations risk, while mediation investigated roles hypertension, diabetes, lipid abnormalities. The found that multivariable-adjusted model, there "U-shaped" association prevalence (China: P for trend = 0.009, non-linear 0.0004; United States: 0.012, 0.0004). Similarly, compared non-pandemic period, long (≥ 9 h) potentially factor among (for those under 60 years old: odds ratio (OR) 95% confidence interval (CI)[1.836(1.138, 2.962)], 0.013; old above: OR 95%CI[1.44(1.15, 1.436)], 0.044). contrast, pandemic stronger non—pandemic period 95%CI[1.342(1.132, 1.59)], 0.001), but no old. Mediation analysis indicated abnormalities partially influenced proportion 8.39% overall population, high 20.25% elderly aged above. During prolonged significantly increased, although this less pronounced China. These findings suggest public health interventions should account varying impact across different populations.
Language: Английский
Citations
0
Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
There are several physiological reasons why biological organisms sleep. One key one concerns brain metabolism. In our article we discuss the role of metabolism in myelin, based on recent discovery that myelin contains mitochondrial components enable production adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). These probably originate from vesiculation membranes form derived vesicles (MDVs). We hypothesize acts as a proton capacitor, accumulating energy protons during sleep and converting it to ATP OXPHOS wakefulness. Empirical evidence supporting hypothesis is discussed, including data metabolic activity, MDVs, allometric scaling between white matter volume duration mammals.
Language: Английский
Citations
0
Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 353 - 374
Published: Feb. 20, 2025
Abstract Health behaviours play a pivotal role in shaping an individual’s health trajectory over the life course, encompassing patterns, actions, and habits that influence overall well-being. This chapter explores origins developmental trajectories of key behaviours, as well determinants behaviour which contribute to inequalities. The focuses primarily on physical activity diet, but also touches sedentary sleep, smoking, alcohol consumption. Childhood adolescence major transitions represent sensitive periods for development, formation, maintenance with strong similarities individual, environmental, societal seen across behaviours. By understanding these dynamic trajectories, interventions can target population groups stages promote healthier consequently populations.
Language: Английский
Citations
0
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: April 29, 2025
Biomarker profiling from biofluids such as blood are widely measured in clinical research, using for example Olink proteomics panels. One research focus area is cardiovascular disease (CVD), which chronic sleep restriction (SR) a risk factor. However, it remains unclear whether levels of commonly CVD biomarkers sensitive to acute dynamic factors SR, physical exercise (PEx), and time day. In this crossover design, 16 normal-weight, healthy men underwent three highly standardized in-lab nights SR (4.25 h/night) normal (NS, 8.5 randomized order, with 88 protein quantified the technology (and selected validation ELISA) morning, evening, immediately before repeatedly after 30 min high-intensity exercise. We found significant time-of-day-dependent changes several biomarkers. Whereas proteins were exercise-induced across conditions (such canonical exerkines IL- 6 BDNF), proteomic dynamics differed response recurrent compared following NS. Moreover, NS resulted biomarker profile previously associated increased prospective CVDs large-scale cohorts higher circulating IL-27 LGALS9). Our findings highlight how physiology can modulate levels. These results also underscore need consider duration key determinant health-an emphasis reflected recent American Heart Association guidelines. Further studies women, older individuals, patients prior CVD, different chronotypes dietary schedules warranted.
Language: Английский
Citations
0
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(19)
Published: May 6, 2025
Past research finds that sleep duration is reliably linked with health yet durations differ substantially between countries. We investigated whether countries shorter have worse health. Study 1 analyzed national from 14 past investigations ( k = 353) and found they were not associated 2 collected data people 20 different N 4,933). Average varied (range 1.57 h). A quadratic relation was in all countries, although the turning points Individuals whose closer to their country’s perceived ideal reported better The results suggest amount of optimal varies across
Language: Английский
Citations
0