Therapeutic Targets and Approaches to Manage Inflammation of NAFLD DOI Creative Commons
Wenjing Geng, Wanying Liao, Xinyuan Cao

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 393 - 393

Published: Feb. 6, 2025

Non-alcoholic fatty liver disease (NAFLD) and its advanced form, non-alcoholic steatohepatitis (NASH), are the leading causes of chronic globally. They driven by complex mechanisms where inflammation plays a pivotal role in progression. Current therapies, including lifestyle changes pharmacological agents, limited efficacy, particularly addressing stages disease. Emerging approaches targeting inflammation, metabolic dysfunction, fibrosis offer promising new directions, though challenges such as treatment complexity heterogeneity persist. This review concludes main therapeutic targets to manage currently emphasizes critical need for future drug development combination therapy NAFLD/NASH management.

Language: Английский

Diets intervene osteoporosis via gut-bone axis DOI Creative Commons
Yuan‐Wei Zhang,

Peiran Song,

Sicheng Wang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 4, 2024

Osteoporosis is a systemic skeletal disease that seriously endangers the health of middle-aged and older adults. Recently, with continuous deepening research, an increasing number studies have revealed gut microbiota as potential target for osteoporosis, research concept gut-bone axis has gradually emerged. Additionally, intake dietary nutrients adoption patterns may affect microbiota, alterations in might also influence metabolic status host, thus adjusting bone metabolism. Based on axis, can participate modulation metabolism by altering abundance, diversity, composition microbiota. Herein, combined emerging literatures relevant studies, this review aimed to summarize impacts different components osteoporosis acting well underlying mechanisms proper recommendations.

Language: Английский

Citations

58
NAFLD and NASH: etiology, targets and emerging therapies DOI

Shulin Wei,

Li Wang, Paul C. Evans

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(3), P. 103910 - 103910

Published: Feb. 1, 2024

Language: Английский

Citations

57
Effects of intestinal Desulfovibrio bacteria on host health and its potential regulatory strategies: A review DOI

Heyi Zhou,

Dandan Huang,

Zetong Sun

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 284, P. 127725 - 127725

Published: April 12, 2024

Language: Английский

Citations

16
Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD DOI Creative Commons
Fabrizio Termite,

Sebastiano Archilei,

Francesca D’Ambrosio

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 56 - 56

Published: Jan. 6, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to range of pathological outcomes, including metabolic steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation progression remain incompletely understood. Oxidative stress peroxidation are pivotal "multiple parallel hit model", contributing cell death tissue damage. Gut microbiota plays substantial role modulating oxidative through multiple pathways: impairing intestinal barrier, which results bacterial translocation inflammation; modifying bile acid structure, impacts signaling cascades involved lipidic metabolism; influencing hepatocytes' ferroptosis, form programmed death; regulating trimethylamine N-oxide (TMAO) activating platelet function, both recently identified as pathogenetic factors MASH progression. Moreover, various exogenous impact gut its involvement MASLD-related stress, such air pollution, physical activity, cigarette smoke, alcohol, dietary patterns. manuscript aims provide state-of-the-art overview focused on intricate interplay between microbiota, peroxidation, pathogenesis, offering insights into potential strategies prevent associated complications.

Language: Английский

Citations

2
Treatment of liver fibrosis: Past, current, and future DOI Open Access
Chunye Zhang, Shuai Liu, Ming Yang

et al.

World Journal of Hepatology, Journal Year: 2023, Volume and Issue: 15(6), P. 755 - 774

Published: June 25, 2023

Liver fibrosis accompanies the progression of chronic liver diseases independent etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated fatty disease. It is commonly associated with injury, inflammation, cell death. characterized by abnormal accumulation extracellular matrix components that are expressed myofibroblasts collagens alpha-smooth actin proteins. Activated hepatic stellate cells contribute to major population myofibroblasts. Many treatments for have been investigated in clinical trials, including dietary supplementation (e.g., vitamin C), biological treatment simtuzumab), drug pegbelfermin natural herbs), genetic regulation non-coding RNAs), transplantation stem hematopoietic cells). However, none these has approved Food Drug Administration. The efficacy can be evaluated histological staining methods, imaging serum biomarkers, well scoring systems, fibrosis-4 index, aspartate aminotransferase platelet ratio, non-alcoholic disease score. Furthermore, reverse slowly frequently impossible advanced or cirrhosis. To avoid life-threatening stage fibrosis, anti-fibrotic treatments, especially combined behavior prevention, treatment, drugs herb medicines, needed. This review summarizes past studies current future fibrosis.

Language: Английский

Citations

40
A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance DOI Creative Commons
Jing Zhou,

Nan Lyu,

Qiongling Wang

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 578, P. 216457 - 216457

Published: Oct. 19, 2023

Tumor-associated macrophages (TAMs), as a major and essential component of tumor microenvironment (TME), play critical role in orchestrating pancreatic cancer (PaC) tumorigenesis from initiation to angiogenesis, growth, systemic dissemination, well immunosuppression resistance chemotherapy immunotherapy; however, the intrinsic factors responsible for TAMs reprograming function remain be identified. By performing single-cell RNA sequencing, transforming growth factor-beta-induced protein (TGFBI) was identified TAM-producing factor murine PaC tumors. express TGFBI human expression is positively related with growth. inducing loss-of-function macrophage (MΦs) vitro siRNA vivo Cre-Lox strategy our developed TGFBI-floxed mice, we demonstrated disruption not only inhibited MΦ polarization M2 phenotype MΦ-mediated stimulation on but also significantly improved anti-tumor immunity, sensitizing association regulation fibronectin 1, Cxcl10, Ccl5. Our studies suggest that targeting can develop an effective therapeutic intervention highly lethal PaC.

Language: Английский

Citations

29
Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function DOI

Dajun Gao,

Cao-Xu Zhang, Huaqi Guo

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123567 - 123567

Published: Feb. 15, 2024

Language: Английский

Citations

9
From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease DOI Creative Commons
Andrea Pasta, Elena Formisano, Francesco Calabrese

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 241 - 241

Published: Jan. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Language: Английский

Citations

1
The bsh1 gene of Lactobacillus plantarum AR113 ameliorates liver injury in colitis mice DOI Creative Commons
Junlin Shao, Yongjun Xia,

Guangqiang Wang

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: Feb. 11, 2025

The Western diet (WD) leads to hepatic lipid metabolism disorders. Previous studies have shown that the bile salt hydrolase 1 (bsh1) gene of Lactobacillus plantarum AR113 attenuates colitis under WD. In this study, we preliminarily explored how inflammatory response in mice on Our study suggests WD abnormalities and dysbiosis gut microflora, furthermore, there may be a correlation between responses. significantly regulated acid liver treated by Dextran sulfate sodium (DSS), affected structure mouse intestinal flora, inhibited expression Sterol regulatory element-binding protein 1C (SREBP-1C) P-NF-κB p65 at level, thereby attenuating injury phenotype. However, bsh1 knockout strain did not exhibit above function.

Language: Английский

Citations

1
The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns DOI Open Access

Hsueh-Han Tsai,

Jyh‐Cherng Yu,

Huan-Ming Hsu

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2057 - 2057

Published: April 25, 2023

Breast cancer is a significant public health problem globally and prevention strategies have become of great interest as its incidence rises. Exploring the connection between dietary patterns reduction breast risk considered promising approach. High levels fiber, phytochemicals, good antioxidant profile, composition advantageous fatty acids are characteristics healthy programs such Mediterranean diet. This review summarized discussed active compounds that important in preventing cancer, including components from recent related reports. These include polyunsaturated acids, alcohol. Although exact mechanism for using these factors not well understood, combination all elements diet plays role reducing risk. Considering elevated probability relapse mortality, it crucial to investigate correlation nutritious pattern while identifying bioactive potential mitigate incidence.

Language: Английский

Citations

20