Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis DOI Creative Commons

Chuan Peng,

Yuling Zhu,

Kaibo Zhang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 21, 2024

Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen oxygen atoms, which suffer short emission wavelengths, low efficiency, limited responsiveness, obscure luminescence mechanisms. Here we present an mechanism bioactive polycysteine, aliphatic polymer that displays polymerization- aggregation-induced emission, high quantum yield, multicolor properties. We show the hydrogen atoms bonded to sulfur play a crucial role luminescence. This enables reversible modulation of fluorescence under reducing oxidizing conditions, facilitating specific imaging quantitative detection redox species cells vivo. Furthermore, exhibits better anti-inflammatory antioxidative activities compared first-line clinical antioxidants, offering promising platform for vivo theragnosis diseases such as osteoarthritis. uses, but usually yields responsiveness. Here, authors report polycysteine natural amino acids intrinsic fluorescence, color switching properties applicability drug-free self-reporting system

Language: Английский

COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson’s Disease Model Mouse Brain DOI
Lin Zhou,

Rongjie Yang,

Xinru Li

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(43), P. 23727 - 23738

Published: Oct. 20, 2023

Parkinson's disease (PD) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in substantia nigra and drastic depletion dopamine (DA) striatum; thus, DA can act as marker for PD diagnosis therapeutic evaluation. However, detecting brain not easy because its low concentration difficulty sampling. In this work, we report fabrication covalent organic framework (COF)-modified carbon fiber microelectrode (cCFE) that enables real-time detection mouse thanks to outstanding antibiofouling antichemical fouling ability, excellent analytical selectivity, sensitivity offered by COF modification. particular, inhibit polymerization on electrode (namely, chemical fouling) spatially confining molecular conformation electrochemical oxidation DA. The cCFE stably continuously work detect monitor variation concentration. Furthermore, it was combined with levodopa administration devise closed-loop feedback mode therapy, which monitors model instruct dose injection time levodopa, allowing customized medication improve efficacy meanwhile avoid adverse side effects. This demonstrates fascinating properties fabricating sensors vivo bioanalysis. We believe structural tunability diversity will offer enormous promise selective neurotransmitters brain.

Language: Английский

Citations

42
Configuration of super-fast Cu2+-responsive chemosensor by attaching diaminomaleonitrile to BODIPY scaffold for high-contrast fluorescence imaging of living cells DOI
Xiaochuan Li, Xuyang Liu, Fangfang Li

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 304, P. 123377 - 123377

Published: Sept. 9, 2023

Language: Английский

Citations

24
Recent progress of molecular fluorescent probes with multi-recognition sites enable sensitive and selective analysis DOI

Haifeng Ge,

Qiaozhen Ye,

Tenglong Zou

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 174, P. 117685 - 117685

Published: April 2, 2024

Language: Английский

Citations

10
Recent advance in the development of the fluorescent responsive probes for the study of ferroptosis DOI
Baoli Dong,

Shijing Li,

Yan Wang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 168, P. 117327 - 117327

Published: Sept. 23, 2023

Language: Английский

Citations

22
Sub-100 ms Level Ultrafast Detection and Near-Infrared Ratiometric Fluorescence Imaging of Norepinephrine in Live Neurons and Brains DOI
Yujie Han,

Leiwen Mao,

Qi‐Wei Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(43), P. 23832 - 23841

Published: Oct. 18, 2023

Norepinephrine (NE) is a key neurotransmitter in the central and sympathetic nervous systems, whose content fluctuates dynamically rapidly various brain regions during different physiological pathophysiological processes. However, it remains great challenge to directly visualize precisely quantify transient NE dynamics living systems with high accuracy, specificity, sensitivity, and, particular, temporal resolution. Herein, we developed series of small-molecular probes that can specifically detect through sequential nucleophilic substitution–cyclization reaction, accompanied by ratiometric near-infrared fluorescence response, within an impressively short time down 60 ms, which 3 orders magnitude faster than present probes. A unique water-promoted intermolecular proton transfer mechanism disclosed, dramatically boosted recognition kinetics ∼680 times. Benefiting from these excellent features, quantitatively imaged endogenous under external stimuli at single neuron level further revealed close correlations between fluctuations Parkinson's disease pathology acute slices live mouse brains vivo.

Language: Английский

Citations

20
The nucleus accumbens in reward and aversion processing: insights and implications DOI Creative Commons
Ying Xu, Yingjie Lin, Ming Yu

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

Citations

8
Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis DOI
Haowen Luo,

Lejie Tian,

Yaoming Zhang

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(7), P. 6443 - 6474

Published: April 12, 2024

Language: Английский

Citations

5
Imaging Neurotransmitters with Small‐Molecule Fluorescent Probes DOI

Anusha Bade,

Peeyush Yadav,

Le Zhang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 4, 2024

Abstract Neurotransmitters play a crucial role in regulating communication between neurons within the brain and central nervous system. Thus, imaging neurotransmitters has become high priority neuroscience. This minireview focuses on recent advancements development of fluorescent small‐molecule probes for neurotransmitter applications these Innovative approaches probe design are highlighted as well attributes which necessary practical utility, with view to inspiring new capable visualizing neurotransmitters.

Language: Английский

Citations

4
Regulating Planarized Intramolecular Charge Transfer for Efficient Single-Phase White-Light Emission in Undoped Metal–Organic Framework Nanocrystals DOI

Yunfeng Yang,

Yixuan Wang, Fu‐Quan Bai

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(32), P. 9898 - 9905

Published: July 15, 2024

The technology of combining multiple emission centers to exploit white-light-emitting (WLE) materials by taking advantage porous metal-organic frameworks (MOFs) is mature, but preparing undoped WLE MOFs remains a challenge. Herein, pressure-treated strategy reported achieve efficient white photoluminescence (PL) in [Zn(Tdc)(py)]

Language: Английский

Citations

4
Activatable red/near-infrared aqueous organic phosphorescence probes for improved time-resolved bioimaging DOI Creative Commons
Yang Li, Zhiqin Wu,

Zizhao Huang

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 12(2)

Published: Oct. 29, 2024

ABSTRACT Organic red/near-infrared (NIR) room-temperature phosphorescence (RTP) holds significant potential for autofluorescence-free bioimaging and biosensing due to its prolonged persistent luminescence exceptional penetrability. However, achieving activatable red/NIR organic RTP probes with tunable emission in aqueous solution remains a formidable challenge. Here we report on intensity lifetime amplification. These consist of supramolecular assemblies comprising macrocyclic cucurbit[8]uril amine-containing alkyl-bridged pyridiniums, exhibiting viscosity-activatable enhanced quantum yield (≤20%) lifetime. Notably, by utilizing this probe, successfully achieve two-photon imaging lysosomal viscosity millisecond-scale time-resolved cell imaging. Moreover, intravital using an probe enables the monitoring variations inflammatory mice, demonstrating significantly improved signal-to-background ratio compared fluorescence This platform facilitates versatile high-resolution vivo tracking specific biomarkers physiological events.

Language: Английский

Citations

4