Diet composition during the early post‐nursing period: in male mice, macronutrients matter DOI Open Access
Elliott S. Neal, Dayna Zimmerman, Rebecca Brady

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(21), P. 4657 - 4658

Published: Sept. 18, 2023

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities DOI
Iliyan D. Iliev, Ashwin N. Ananthakrishnan, Chun‐Jun Guo

et al.

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

1
Effects of prenatal THC vapor exposure on body weight, glucose metabolism, and feeding behaviors in chow and high-fat diet fed rats DOI
Catherine Hume, Samantha L. Baglot,

Lucia Javorcikova

et al.

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(7), P. 981 - 992

Published: March 25, 2024

Language: Английский

Citations

4
Development of a comprehensive food glycomic database and its application: Associations between dietary carbohydrates and insulin resistance DOI Creative Commons
Christopher Suarez, Shawn Ehlers Cheang,

Jules A. Larke

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 473, P. 142977 - 142977

Published: Jan. 20, 2025

Language: Английский

Citations

0
Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides DOI Creative Commons

Hidenori Shimizu,

Junki Miyamoto,

Keiko Hisa

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 29, 2025

Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. may prevent obesity caused excess sucrose intake exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived produced high EPS levels but not other sugars. abundance was significantly decreased donors with compared healthy donors, and EPS–SCFA carbohydrate process attenuated. Our findings reveal an important which host–commensal interactions glycometabolism energy regulation, suggesting approach for preventing lifestyle-related diseases prebiotics probiotics targeting metabolites. While diet is essential daily nutrient acquisition, excessive sugar-rich foods drives related issues like diabetes. authors show bacterium curbs transforming sugars into beneficial compounds.

Language: Английский

Citations

0
Specific Macronutrient clusters associated with lower mortality Risk: Evidence from NHANES 1999–2018 DOI Creative Commons

Jiaying Yu,

Yang Chen, Defang Li

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Accumulating evidence suggest that imbalanced macronutrient composition would increase the risk of chronic diseases. However, previous studies predominantly focused on individual macronutrients often failed to thoroughly elucidate this complex association. This study aimed comprehensively analyze relationship between clusters and all-cause mortality. The included 26,615 adults aged 20-75 years from National Health Nutrition Examination Survey (NHANES) 1999-2018. A three-dimensional cube method was employed categorize intake. association dietary mortality investigated using Cox proportional hazards modeling restricted cubic spline (RCS) analysis. Over a weighted median follow-up duration 7.58 years, 3,998 deaths were recorded. After adjusting for potential confounders, compared with reference Cluster Pm:Fm:Cmh, 4 specific Clusters associated reduced mortality: Pm:Fm:Cm (HR: 0.79, 95 % CI: 0.67-0.92), Pm:Fmh:Cml 0.76, 0.61-0.95), Pm:Fmh:Cm 0.86, 0.75-0.97), Pl:Fm:Cmh 0.73, 0.60-0.89). Three-node RCS analysis revealed non-linear relationships carbohydrate within protein overall Subgroup sensitivity analyses corroborated robustness these associations across different age, gender, energy intake levels. approach human into 24 clusters. Pm:Fm:Cm, Pm:Fmh:Cml, Pm:Fmh:Cm, exhibited lower risk. Different could be precondition in nutrition intervene strategy.

Language: Английский

Citations

0
A murine model of obesity with hyperinsulinemia and hepatic steatosis involving neurosecretory protein GL gene and a low-fat/medium-sucrose diet DOI

Yuki Narimatsu,

Masaki Kato, Kazuyoshi Ukena

et al.

Peptides, Journal Year: 2025, Volume and Issue: 186, P. 171376 - 171376

Published: Feb. 23, 2025

Language: Английский

Citations

0
High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence DOI Creative Commons
Duan Ni, Alistair M. Senior, David Raubenheimer

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease burden (prevalence and incidence). Here, supply, GDP, idiopathic data were collated from more than 150 countries 1990 2018. Nutritional geometry generalized additive mixed models (GAMMs) modeling unraveled that high‐fat low‐carbohydrate supplies linked lower incidence prevalence. Our analyses suggested a plausible role of

Language: Английский

Citations

0
Effects of Multivitamin Supplementation on Metabolic Parameters in High- and Low-Fat Diet-Fed C57BL/6J Mice: Potential Links to Adipose Tissue Browning and Gut Microbiome DOI Open Access
Mehrnaz Abbasi,

Braeden Heath,

Lauren McGinness

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1045 - 1045

Published: March 17, 2025

Background/Objectives: The relationship between diet, micronutrient supplementation, and metabolic regulation emphasizes the potential of nutritional strategies to address obesity related disorders. Certain vitamins have enhance thermogenesis health. However, impact multivitamin supplementation on white adipose tissue (WAT) browning, gut microbiome (GM), function is not well understood. This study investigated effects obesity-related dysfunction in mice fed a high-fat diet (HFD) or low-fat (LFD). Methods: Male C57BL/6J were assigned group 1: control chow (CHD); 2: HFD; 3: multivitamin-supplemented HFD (Mv-HFD); 4: LFD; 5: LFD (Mv-LFD). Diets, either supplemented with multivitamins A, D, B1, B5, C non-supplemented, administered for 12 weeks. Metabolic parameters, GM composition analyzed. Results: Mv-HFD significantly reduced weight gain, mass, blood glucose levels, insulin resistance induced by an HFD. Additionally, it increased energy expenditure thermogenic gene expression WAT. Both Mv-LFD improved increasing beneficial bacteria. Conclusions: Multivitamin health potentially promoting WAT enhancing expenditure, modulating composition. These findings suggest that could offer promising strategy combating associated dysfunction.

Language: Английский

Citations

0
High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection DOI Creative Commons
Duan Ni, Jian Tan,

Julen Gabirel Araneta Reyes

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) believed to be driven by autoimmune mechanisms. Genetic environmental factors are implicated in MS development, among latter, diets nutrients emerging as potential critical contributors. However, a comprehensive understanding their impacts underlying mechanisms involved lacking. Harnessing state‐of‐the‐art nutritional geometry analytical methods, it first revealed that globally, increased carbohydrate supply associated with burden, while fat has opposite effect. Furthermore, mouse model, experimental encephalomyelitis (EAE), found isocaloric diet high aggravated EAE, enriched (HF) fully protective. This reflected reduced neuroinflammation skewing toward anti‐inflammatory phenotypes. The protective effects from HF multifaceted. Metabolically, lipid storage immune cells, correlating IL‐10 production. Transcriptionally epigenetically, feeding preprogrammed naïve T cells less activated but more tolerogenic phenotype. It showcased manipulating potentially efficient cost‐effective approach prevent and/or ameliorate EAE. exhibits translational potentials for prevention/intervention possibly other diseases.

Language: Английский

Citations

0
The Combined Effects of High-Intensity Interval Exercise Training and Dietary Supplementation on Reduction of Body Fat in Adults with Overweight and Obesity: A Systematic Review DOI Open Access
Eliza Gaweł, Barbara Hall, Szymon Siatkowski

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 355 - 355

Published: Jan. 25, 2024

Excessive body fat is associated with various comorbidities including cardiovascular disease, type 2 diabetes mellitus and certain types of cancer. The search for effective, relatively easy to maintain body-fat reduction interventions has been ongoing. We aimed review the current literature assess effectiveness high-intensity interval training without dietary supplementation on loss, concentration markers metabolic health aerobic capacity adults overweight obesity. Seventy full-text articles were assessed determine their eligibility thirteen included in review. methodology this systematic was developed according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Almost all studies (93%) demonstrated protocols reducing fat, improving These effects enhanced by an addition a supplement, such as green tea or ginger other. Although combining HIIT seem improve composition, obesity some instances greater extent than alone, it does not be necessary combine these two interventions.

Language: Английский

Citations

3