Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105822 - 105822
Published: Dec. 1, 2024
Language: Английский
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: March 1, 2024
Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.
Language: Английский
Citations
23
Trends in Cell Biology, Journal Year: 2024, Volume and Issue: 34(8), P. 626 - 635
Published: Jan. 21, 2024
Language: Английский
Citations
19
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657
Published: Jan. 7, 2025
Language: Английский
Citations
3
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 8, 2025
Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, deep mechanism between microbiota-TME interaction has not been well explored. In this study, we for first time discovered that Lactobacillus intestinalis (L. intestinalis) effectively suppressed growth both AOM/DSS-induced CRC model and ApcMin/+ spontaneous adenoma model. Our investigation revealed L. increased infiltration immune cells, particularly dendritic cells (DC), TME. Mechanically, tumor-derived CCL5 induced by recruited DC chemotaxis through NOD1/NF-κB signaling pathway. clinical samples datasets, found positive correlation intestinalis, level, DC-related genes. study provided new strategy microbial intervention deepened understanding modulated gut microbes.
Language: Английский
Citations
2
Aging Cell, Journal Year: 2024, Volume and Issue: 23(4)
Published: Jan. 18, 2024
Abstract Aging‐induced cognitive impairment is associated with a loss of metabolic homeostasis and plasticity. An emerging idea that targeting key metabolites sufficient to impact the function other organisms. Therefore, more metabolism‐targeted therapeutic intervention needed improve impairment. We first conducted untargeted metabolomic analyses 16S rRNA identify aging‐associated adaption intestinal microbiome change. Untargeted plasma revealed L‐arginine was altered during aging process. Impaired low abundance Akkermansia muciniphila ( AKK ) colonization in mice. Long‐term supplementation outer membranes protein‐Amuc_1100, rescued level restored Mechanically, Amuc_1100 acted directly as source enriched L‐arginine‐producing bacteria. In aged brain, promoted superoxide dismutase alleviated oxidation stress, increased nitric oxide, derivatives L‐arginine, synaptic Meanwhile, repaired lipopolysaccharide‐induced barrier damage growth colon organoid. Our findings indicated aging‐related closely disorders metabolism. ‐derived Amuc_1100, potential postbiotic, metabolism, might provide promising strategy maintain aging.
Language: Английский
Citations
10
Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)
Published: Aug. 15, 2024
Abstract The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, predisposition age‐associated diseases. Cellular senescence, characterized by cessation of cell division response various stressors, induces morphological functional changes within tissues. complexity heterogeneity senescent cells, alongside secretion senescence‐associated secretory phenotype, exacerbate process through pro‐inflammatory pathways influence microenvironment immune system. Concurrently, aging‐associated diversity composition contribute dysbiosis, further exacerbating inflammation undermining integrity bodily functions. This review encapsulates burgeoning research on reciprocal relationship highlighting their collective impact age‐related musculoskeletal diseases, including osteoporosis, sarcopenia, osteoarthritis. It also explores potential modulating targeting innovative strategies healthy mitigating progression aging‐related conditions. By exploring targeted interventions, development senotherapeutic drugs probiotic therapies, this aims shed light novel therapeutic avenues. These leverage connection advance interventions aimed at extending health span improving quality life older population.
Language: Английский
Citations
7
Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade elimination remains poorly characterized. Combining single-cell RNA sequencing (scRNA-seq), dual-recombinase-based lineage tracing, other approaches, we identified WNT-activated subpopulation of malignant that act as vivo. We found intensive reciprocal interactions between regulatory tumor-associated macrophages (Reg-TAMs) via GAS6-AXL/MERTK signaling pathways, which facilitated the escape TICs. Our study employed chemical inhibitors Axl/Mertk conditional double knockout mice to demonstrate inhibiting interaction TIC-derived GAS6 AXL/MERTK Reg-TAMs reactivated anti-tumor responses. CCL8 critical mediator GAS6/AXL/MERTK pathway, primarily by T cell (Treg) infiltration into tumor. Furthermore, blockade sensitized tumor anti-PD-1 treatment. Thus, elucidated detailed mechanism immunity, providing insights strategies eradicate conventional immunotherapy.
Language: Английский
Citations
0
MethodsX, Journal Year: 2025, Volume and Issue: unknown, P. 103268 - 103268
Published: March 1, 2025
Recent advances in the study of gut microbiota has pointed to its under-utilized source potentially beneficial bacteria, known as next generation probiotics, offering a promising avenue restore or compensate impaired toward healthy state. Aside from difficulties achieve in-lab adequate culture conditions, use bacterial isolates is also limited by their bioavailability donor itself. In iTARGET study, we positively selected donors based on diet enriched fiber, that been shown increase prevalence species associated with health. The monocenter, prospective, observational adults lifestyle and high daily fiber consumption. We aim recruit individuals two phases, first one for all will permit identification carriers bacteria interest second phase subset allow isolation previously identified bacteria. Our primary outcome at least isolate. secondary outcomes comprised throughput metagenomic profiles intestinal characterization cultured isolates. was approved French Research Ethics Committees (Comité de Protection des Personnes Sud-Est I) under National reference ID 2023-A01677-38. Study findings results be published peer-reviewed Open Access journals. (Trial registration number ClinicalTrials.gov: NCT06166810).
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102752 - 102752
Published: April 1, 2025
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106828 - 106828
Published: May 1, 2025
Language: Английский
Citations
0