Chemical Engineering Science, Journal Year: 2024, Volume and Issue: 300, P. 120654 - 120654
Published: Aug. 24, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(44)
Published: July 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Language: Английский
Citations
11
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 6, 2024
Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356) for synergistic SDT/immunotherapy. Specifically, a‐CoW‐LDH act as sonosensitizer generate abundant reactive oxygen species (ROS) under US irradiation. After loading a‐LDH@356 plus irradiation not only effectively induces ROS generation immunogenic death, but also inhibits elevation citrullinated histone H3 (H3cit) release NETs, enabling enhancement anti‐tumor metastasis effect. Using 4T1 model, it that combining YW3‐56 stimulates an by upregulating proportion immune‐activated cells inducing polarization M1 macrophages, escape downregulating expression PD‐1 on irradiation, which arrests primary progression inhibition rate 69.5% prevents least number lung nodules.
Language: Английский
Citations
10
Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(7), P. 549 - 563
Published: June 23, 2024
Language: Английский
Citations
8
Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123109 - 123109
Published: Jan. 13, 2025
Language: Английский
Citations
1
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 20, 2025
Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.
Language: Английский
Citations
1
Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 24, 2025
Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.
Language: Английский
Citations
1
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 667, P. 91 - 100
Published: April 10, 2024
Language: Английский
Citations
7
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 214 - 223
Published: Sept. 29, 2024
Language: Английский
Citations
7
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(28)
Published: April 30, 2024
Abstract Autophagy could play suppressing role in cancer therapy by facilitating release of tumor antigens from dying cells and inducing immunogenic cell death (ICD). Therefore, discovery rational design more effective inducers cytotoxic autophagy is expected to develop new strategies for finding innovative drugs precise successful treatment. Herein, we MoO 3‐x nanowires (MoO NWs) with high oxygen vacancy strong photothermal responsivity ablate tumors through hyperthermia, thus promote the induction severe ICD. As expected, combination NWs (PTT) effectively induces ablated cells, maturation antigen presentation dendritic (DCs), subsequently activates T lymphocytes (CTLs)‐mediated adaptive immunity. Furthermore, treatment immune checkpoint blockade PD‐1 tumor‐associated macrophages (TAMs) polarization into tumor‐killing M1 macrophages, inhibit infiltration Treg at sites, alleviate immunosuppression microenvironment, finally intensify anti‐tumor activity vivo. This study provides a strategy preliminary elucidation mechanism using induce enhance immunotherapy.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 13, 2024
Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas central nervous system. The efficacy sonodynamic therapy (SDT) against GBM significantly reduced by expression apoptosis-inhibitory proteins in cells. In this study, an intelligent nanoplatform (denoted as Aza-BD@PC NPs) based on aza-boron-dipyrromethene dye phenyl chlorothionocarbonate-modified DSPE-PEG molecules developed for synergistic ferroptosis-enabled gas (GT) SDT GBM. Once internalized cells, NPs showed effective cysteine (Cys) consumption Cys-triggered hydrogen sulfide (H
Language: Английский
Citations
6