Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Comprehensive
Summary
The
invention
of
novel
linkers
is
a
long‐lasting
task
in
the
area
sulfur(VI)
fluoride
exchange
reaction
(SuFEx).
Compared
with
most
frequently
investigated
sulfonyl
fluorides,
synthetic
accessibility
toward
its
mono‐aza
isostere,
i.e.
,
sulfonimidoyl
fluorides
still
limited.
Herein,
we
report
an
electrochemical
carbonfluorination
readily
available
N
‐sulfinylamines
to
access
various
aryl
and
alkyl
fluorides.
transformation
characterized
by
ready
availability
starting
materials,
mild
conditions,
obviating
metal
catalysts
chemical
oxidants.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(17), P. 2695 - 2702
Published: June 24, 2024
Abstract
A
straightforward
and
efficient
electrochemical
method
for
the
anodic
oxidative
selenenylation
of
2-(2-arylallyl)phenols
a
2-(3-arylbut-3-en-1-yl)phenol
with
diselenides
under
ambient
air
conditions
has
been
outlined.
This
allows
synthesis
selenyl-dihydrobenzofurans
chromane
featuring
sterically
hindered
tetrasubstituted
carbon
center,
demonstrated
through
25
examples
yields
reaching
up
to
98%.
Initial
mechanistic
investigations
suggest
likely
participation
pivotal
seleniranium
cation
species
in
regulating
reactivity.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(47)
Published: Aug. 27, 2024
Abstract
Electroreduction
is
an
important
aspect
of
organic
electrochemistry.
Its
chemistry
does
not
require
the
addition
additional
reductants,
making
it
effective
alternative
to
various
traditional
reduction
reactions.
Among
them,
organo‐mediated
electroreduction
recognized
as
a
promising
approach.
Organo‐mediators
can
be
reduced
directly
at
cathode
form
reactive
radical
anions
that
subsequently
reduce
substrate
via
electron
transfer
(
ET
)
initiate
reaction
being
investigated.
typically
have
more
positive
potential,
and
their
role
in
whole
similar
catalysts.
Their
transforms
process
from
original
heterogeneous
into
homogeneous
one.
Organo‐mediated
effectively
avoid
over‐electrolysis
product
electrode
intolerance
sensitive
substrates
or
functional
groups
during
electrolysis,
thereby
preventing
occurrence
side
It
also
prevent
excessive
consumption
reagents
electrical
energy
while
promoting
achieve
higher
completely
different
selectivity.
Considering
advantages
this
type
reaction,
review
will
provide
detailed
description
reactions
mediated
by
molecules
recent
years
elucidate
mechanism
organo‐mediators
transformations.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7555 - 7559
Published: Sept. 3, 2024
A
practical
denitrative
cyanation
of
feedstock
nitroarenes
under
mild
and
transition
metal-free
reaction
conditions
has
been
developed.
The
key
to
success
lies
in
the
use
electrochemically
driven,
inexpensive
ionic
liquid
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Sulfur‐centered
electrophilic
‘warheads’
have
emerged
as
key
components
for
chemical
proteomic
probes
through
sulfur‐exchange
chemistry
(SuFEx)
with
protein
nucleophiles.
Among
these
functional
groups,
sulfonimidoyl
fluorides
(SIFs)
stand
out
their
modifiable
sites,
tunable
electrophilicities,
and
chiral
sulfur‐center,
presenting
exciting
possibilities
new
covalent
probes.
However,
the
synthetic
access
to
SIFs
has
been
a
challenge,
limiting
exploration
applications.
In
this
study,
we
describe
convenient
route
obtain
from
readily
available
sulfenamides
via
series
of
one‐pot
tandem
reactions
high
enantiomeric
excess
(ees).
The
resulting
were
further
converted
into
diverse
array
S(VI)
derivatives
under
mild
conditions
or
in
buffer
solutions.
Most
significantly,
specificity
ligation
experiments
underscored
critical
role
sulfur‐center
chirality
design
screening
more‐selective
therapeutics.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(46), P. 9967 - 9972
Published: Nov. 8, 2024
An
efficient
nickel-catalyzed
direct
fluorosulfonylation
of
vinyl
bromides
and
benzyl
under
mild
reaction
conditions
has
been
developed
for
sulfonyl
fluorides
utilizing
Na
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Comprehensive
Summary
The
invention
of
novel
linkers
is
a
long‐lasting
task
in
the
area
sulfur(VI)
fluoride
exchange
reaction
(SuFEx).
Compared
with
most
frequently
investigated
sulfonyl
fluorides,
synthetic
accessibility
toward
its
mono‐aza
isostere,
i.e.
,
sulfonimidoyl
fluorides
still
limited.
Herein,
we
report
an
electrochemical
carbonfluorination
readily
available
N
‐sulfinylamines
to
access
various
aryl
and
alkyl
fluorides.
transformation
characterized
by
ready
availability
starting
materials,
mild
conditions,
obviating
metal
catalysts
chemical
oxidants.
