Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(16), P. 5477 - 5491
Published: Jan. 1, 2024
ATP11A, a P-type ATPase, functions as flippases at the plasma membrane to maintain cellular function and vitality in several cancers. However, role of ATP11A gastric cancer remains unknown. This study aimed identify related biological behavior cancer, elucidate underlying mechanism.
Language: Английский
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Dec. 8, 2023
Abstract Gastric cancer (GC) is a heterogeneous disease, threatening millions of lives worldwide, yet the functional roles long non-coding RNAs (lncRNAs) in different GC subtypes remain poorly characterized. Microsatellite stable (MSS)/epithelial-mesenchymal transition (EMT) most aggressive subtype associated with poor prognosis. Here, we apply integrated network analysis to uncover lncRNA heterogeneity between subtypes, and identify MIR200CHG as master regulator mediating EMT specifically MSS/EMT GC. The expression silenced by promoter hypermethylation, reverses mesenchymal identity cells vitro inhibits metastasis vivo. Mechanistically, not only facilitates biogenesis its intronic miRNAs miR-200c miR-141, but also protects from target-directed miRNA degradation (TDMD) through direct binding miR-200c. Our studies reveal landscape subtype-specific regulatory network, providing clinically relevant biological insights towards
Language: Английский
Citations
27
BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 30, 2024
A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing role initiating gene expression. Identifying promoters and their strengths can provide valuable information related to human diseases. In recent years, computational methods have gained prominence as an effective means for identifying promoter, offering more efficient alternative labor-intensive biological approaches.
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 16, 2025
Multiple Myeloma (MM) is the second most common malignancy of hematopoietic system, accounting for approximately 10% all hematological malignancies, and currently, there no complete cure. Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in initiation progression tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, lncRNA-RNA binding proteins (RBP). Despite significant clinical application potential lncRNAs, this area still faces challenges due to their low abundance technical limitations. To our knowledge, review first comprehensively integrate elucidate three mechanisms action lncRNAs MM, propose therapeutic targets cases based on these mechanisms. We highlight latest advancements biomarkers targets, offering not only comprehensive analysis MM but also new perspectives methods future diagnosis treatment multiple myeloma.
Language: Английский
Citations
1
Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 227 - 227
Published: Feb. 5, 2025
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 bp, which were initially thought to be noise from genomic transcription without biological function. However, since the discovery H19 in 1980 and Xist 1990, increasing evidence has shown that lncRNAs regulate gene expression at epigenetic, transcriptional, post-transcriptional levels through specific regulatory actions involved development cancer other diseases. Despite many being expressed lower those protein-coding genes less sequence conservation across species, have become an intense area research. They exert diverse functions such as inducing chromatin remodeling, recruiting transcriptional machinery, acting competitive endogenous for microRNAs, modulating protein–protein interactions. Epithelial–mesenchymal transition (EMT) is developmental process, associated embryonic development, wound healing, progression. In context oncogenesis, EMT program transiently activated confers migratory/invasive stem cell (CSC) properties tumor cells, crucial malignant progression, metastasis, therapeutic resistance. Accumulating revealed play roles regulation epithelial/mesenchymal plasticity (EMP) stemness. Here, we summarize emerging molecular mechanisms regulating EMP their effects on initiation progression CSCs. We also discuss potential diagnostic prognostic biomarkers targets.
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.
Language: Английский
Citations
1
Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)
Published: Feb. 1, 2025
Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated the pathological processes of different NDDs, process misfolding aggregation remains notably similar across various conditions. Specifically, undergo into beta‐folded (β‐folded) conformation, resulting formation insoluble amyloid proteins. Despite advancements comprehending certain facets this intricate remain incompletely elucidated. In recent years, concept that long non‐coding RNAs (lncRNAs) contribute to has gained recognition. LncRNAs influence aggregates by facilitating overexpression through regulation gene transcription translation, inhibiting degradation via lysosomal autophagic pathways, targeting aberrant modifications phase transitions A better understanding relationship between lncRNAs is an important step dissecting underlying molecular mechanisms will discovery new therapeutic targets strategies. Highlights NDDs marked leading dysfunction loss function. being involved β‐folded conformations forming consistent role attention, as they regulate inhibit degradation, target modifications. Understanding link crucial for uncovering developing targets.
Language: Английский
Citations
1
Redox Biology, Journal Year: 2024, Volume and Issue: 77, P. 103362 - 103362
Published: Sept. 18, 2024
Language: Английский
Citations
7
Experimental Cell Research, Journal Year: 2025, Volume and Issue: 445(2), P. 114406 - 114406
Published: Jan. 4, 2025
Language: Английский
Citations
0
Methods, Journal Year: 2025, Volume and Issue: 235, P. 71 - 80
Published: Feb. 8, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 6, 2025
Gastric cancer (GC) is a highly aggressive malignancy associated with poor prognosis, particularly in its advanced stages. Neutrophil extracellular traps (NETs) have been implicated progression and immune therapy responses; however, the role of NETs-related long non-coding RNAs (lncRNAs) GC remains poorly understood. This study used data from Cancer Genome Atlas (TCGA) previous research to identify lncRNAs GC. A prognostic signature comprising four (NlncSig) was developed validated, serving as predictor for patient survival response immunotherapy. The NlncSig correlated poorer outcomes high-risk patients demonstrated that those lower risk scores exhibited more favorable responses In vitro experiments confirmed LINC01150 enhances cell proliferation, migration, invasion. robust provides reliable tool predicting characteristics GC, potential guide personalized therapeutic approaches improve care.
Language: Английский
Citations
0