Nature and Science of Sleep,
Journal Year:
2024,
Volume and Issue:
Volume 16, P. 2143 - 2150
Published: Dec. 1, 2024
Obstructive
sleep
apnea
(OSA)
is
a
contributing
factor
to
nonalcoholic
fatty
liver
disease
(NAFLD).
This
study
aimed
investigate
the
clinical
and
polysomnographic
characteristics
of
OSA
patients
with
without
NAFLD,
focusing
on
relationships
between
fragmentation,
arousal
NAFLD.
We
consecutively
enrolled
who
underwent
polysomnography,
anthropometry,
blood
sampling,
abdominal
ultrasonography.
Patients
were
categorized
into
NAFLD
non-NAFLD
groups.
A
comparative
analysis
profiles
was
conducted,
followed
by
multivariate
binary
logistic
regression
explore
relationship
disturbance
indices
total
403
subjects
included,
including
92
311
non-NAFLD.
exhibited
greater
apnea-hypopnea
index
(AHI)
(51.19/h
vs
33.60/h,
p
=
0.002)
oxygen
desaturation
(ODI)
(37.90/h
21.40/h,
p=0.034)
compared
patients.
Specifically,
had
higher
rapid
eye
movement
(REM)-AHI
(53.70/h
43.60/h,
p=0.001)
(AI)
(32
25,
0.009).
Additionally,
latency
(SL)
significantly
lower
in
group
(p
<
0.05).
Multivariate
confirmed
that
REM-AHI
(OR=1.023,
0.024),
AI
(OR=1.140,
0.01),
SL
(OR=0.956,
0.035)
associated
revealed
indices,
especially
AI,
SL,
closely
related
When
evaluating
whether
are
complicated
more
attention
should
be
given
fragmentation
arousal.
Cell Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Sleep
deficiency
is
associated
with
obesity,
but
the
mechanisms
underlying
this
connection
remain
unclear.
Here,
we
identify
a
sleep-inducible
hypothalamic
protein
hormone
in
humans
and
mice
that
suppresses
obesity.
This
cleaved
from
reticulocalbin-2
(RCN2),
name
it
Raptin.
Raptin
release
timed
by
circuit
vasopressin-expressing
neurons
suprachiasmatic
nucleus
to
RCN2-positive
paraventricular
nucleus.
levels
peak
during
sleep,
which
blunted
sleep
deficiency.
binds
glutamate
metabotropic
receptor
3
(GRM3)
of
hypothalamus
stomach
inhibit
appetite
gastric
emptying,
respectively.
Raptin-GRM3
signaling
mediates
anorexigenic
effects
via
PI3K-AKT
signaling.
Of
note,
verify
connections
between
deficiencies
sleeping
state,
impaired
release,
obesity
patients
Moreover,
carrying
an
RCN2
nonsense
variant
present
night
eating
syndrome
These
data
define
unique
food
intake
prevents
Redox Biology,
Journal Year:
2024,
Volume and Issue:
76, P. 103321 - 103321
Published: Aug. 19, 2024
Cell
death
constitutes
a
critical
component
of
the
pathophysiology
cardiovascular
diseases.
A
growing
array
non-apoptotic
forms
regulated
cell
(RCD)-such
as
necroptosis,
ferroptosis,
pyroptosis,
and
cuproptosis-has
been
identified
is
intimately
linked
to
various
conditions.
These
RCD
are
governed
by
genetically
programmed
mechanisms
within
cell,
with
epigenetic
modifications
being
common
crucial
regulatory
method.
Such
include
DNA
methylation,
RNA
histone
acetylation,
non-coding
RNAs.
This
review
recaps
roles
modifications,
RNAs
in
diseases,
well
which
regulate
key
proteins
involved
death.
Furthermore,
we
systematically
catalog
existing
pharmacological
agents
targeting
novel
their
action
article
aims
underscore
pivotal
role
precisely
regulating
specific
pathways
thus
offering
potential
new
therapeutic
avenues
that
may
prove
more
effective
safer
than
traditional
treatments.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
209, P. 107466 - 107466
Published: Oct. 15, 2024
Myocardial
ischemia
causes
extensive
damage,
further
exacerbated
by
reperfusion,
a
phenomenon
called
myocardial
ischemia/reperfusion
injury
(MIRI).
Nowadays,
the
pathological
mechanisms
of
MIRI
have
received
attention.
Oxidative
stress,
multiple
programmed
cell
deaths,
inflammation
and
others
are
all
essential
contributing
to
MIRI.
Mitochondria
energy
supply
centers
cells.
Numerous
studies
found
that
abnormal
mitochondrial
function
is
an
"culprit"
MIRI,
mitophagy
mediated
phosphatase
tensin
homolog
(PTEN)-induced
kinase
1
(PINK1)/Parkin
signaling
pathway
integral
part
maintaining
function.
Therefore,
exploring
association
between
PINK1/Parkin
pathway-mediated
crucial.
This
review
will
mainly
summarize
crucial
role
in
MIR-induced
several
various
potential
interventions
affect
mitophagy,
thus
ameliorating
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 791 - 812
Published: Jan. 1, 2025
The
common
occurrence
of
atrial
fibrillation
(AF)
as
a
cardiac
arrhythmia,
along
with
its
link
to
sleep
deprivation
(SD),
is
gaining
more
acknowledgment.
Even
progress
in
comprehending
the
development
AF,
molecular
connections
between
SD
and
AF
are
still
not
well-defined.
objective
this
research
was
pinpoint
shared
routes
responsible
for
SD-induced
investigate
possible
treatment
targets.
Utilizing
bioinformatics,
we
examined
two
transcriptome
datasets
from
Gene
Expression
Omnibus
(GEO)
database
genes
differential
expression
(DEGs)
AF.
Analyses
focusing
on
functional
enrichment,
such
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG),
were
conducted
crucial
biological
mechanisms
pathways.
Furthermore,
utilized
immunofluorescence
Western
blot
techniques
evaluate
YBX1
role
activating
NLRP3
inflammasomes
rat
model
induced
by
SD.
A
total
540
DEGs
precisely
identified
data
collections.
Studies
emphasizing
enrichment
have
highlighted
significance
inflammation
pathways,
particularly
NOD-like
receptor
signaling
route.
application
machine
learning
uncovered
four
genes-CDC5L,
MAPK14,
RAB5A,
YBX1-with
becoming
predominant
gene
diagnostic
processes.
Investigating
immune
penetration
revealed
significant
specific
cell
types,
notably
CD8+
T
cells
M1
macrophages.
Live
studies
demonstrated
that
amplifies
electrical
rearrangement,
structural
changes,
infiltration
inflammatory
cells,
heightened
presence
inflammasome
elements.
pinpoints
SD-related
possibly
influencing
impact
via
route
invasion
cells.
results
offer
understanding
processes
behind
propose
focus
reduce
risk
caused
Cardiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 37
Published: Jan. 17, 2025
Autonomic
innervation
of
the
heart
plays
a
pivotal
role
not
only
in
regulating
rate
but
also
modulating
cardiac
cell
microenvironment
via
cell-cell
interactions
and
influencing
heart's
repair
capabilities.
Currently,
primary
clinical
approach
for
treating
myocardial
infarction
(MI)
is
percutaneous
coronary
intervention.
However,
salvage
remains
low
patients
with
advanced
disease.
MI
recognized
as
an
autonomic
nervous
system
disorder,
marked
by
sympathetic
hyperactivity
loss
parasympathetic
nerves.
Following
MI,
ventricular
nerve
sprouting
occurs,
leading
to
increase
and,
consequently,
increased
risk
arrhythmia,
which
cause
sudden
death
history
MI.
The
vagus
positively
regulates
cardiomyocyte
proliferation
regeneration,
enhancing
remodeling
function
post-MI.
This
process
highly
significant
treatment
rehabilitation
Cardiac
nerves
are
influenced
factors
such
inflammation,
immunity,
intercellular
communication,
metabolism,
genetics,
epigenetics,
cytokine
secretion
related
mesenchymal
In
recent
years,
advancements
have
been
made
regarding
specifically
fields
therapies,
stem
extracellular
vesicle
treatments,
traditional
Chinese
medicine
acupuncture
moxibustion,
peripheral
electrophysiological
stimulation
bioengineering
materials.
balance
dominance
between
systems
affects
tissue
regeneration
after
neurons
repair.
neural
therapy
involves
multiple
medicine,
biomaterials,
therapy,
drug
research
development,
has
broad
development
prospects
Key
Messages:
regulation
exerted
on
significantly
influences
prognosis
modulation
inflammation
complex
cardiomyocytes,
immune
cells,
fibroblasts,
adipocytes,
other
cellular
components.
Genetic
epigenetic
modifications,
well
shifts
energy
play
crucial
roles.
