ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(47), P. 64592 - 64608
Published: Nov. 13, 2024
Type
I
interferons
(IFNs)
are
essential
for
activating
dendritic
cells
(DCs)
and
presenting
tumor-associated
antigens
to
T
cells.
IFNs
primarily
produced
from
DCs
among
immune
A
combination
of
chemotherapy
metalloimmunotherapy
induces
IFN
production
by
the
cyclic
GMP-AMP
synthase-stimulator
interferon
genes
(cGAS-STING)
pathway.
However,
chemotherapeutic
agents
deplete
DC
populations,
suppressing
immunostimulatory
activities,
despite
their
potent
anticancer
activities.
Furthermore,
an
optimal
ratio
between
metal
at
highest
level
has
not
been
reported,
evidence
ensuring
survival
is
lacking.
In
this
study,
we
hypothesized
that
there
yield
maturation
activity
with
minimal
depletion.
To
demonstrate
it,
have
designed
a
pH
redox
dual-responsive
nanoparticle,
MnO2@BSA@DOX
(MD),
prevent
depleting
activate
cGAS-STING
pathway
both
in
cancer
DCs,
inducing
considerable
levels
maturation.
MD
consists
core-layer
structure,
manganese
dioxide
(MnO2)
core,
cross-linked
layer
bovine
serum
albumin
(BSA)
doxorubicin
(DOX),
specific
DOX
manganese.
exhibits
structure-based
selectivity
targeting
extracellular
tumor
microenvironment
intracellular
reactions
Among
various
formulations,
1:1
shows
no
significant
Moreover,
it
distinct
cytotoxicity
through
apoptosis
activation,
leading
increased
calreticulin
expression
enhanced
phagocytosis.
Consequently,
results
superior
suppression
prolonged
high
accumulation
observed
systemic
toxicities,
highlighting
its
potential
as
therapeutic
agent
treatments.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Nov. 21, 2024
Metabolic
alterations,
a
hallmark
of
cancer,
enable
tumor
cells
to
adapt
their
environment
by
modulating
glucose,
lipid,
and
amino
acid
metabolism,
which
fuels
rapid
growth
contributes
treatment
resistance.
In
primary
breast
metabolic
shifts
such
as
the
Warburg
effect
enhanced
lipid
synthesis
are
closely
linked
chemotherapy
failure.
Similarly,
metastatic
lesions
often
display
distinct
profiles
that
not
only
sustain
but
also
confer
resistance
targeted
therapies
immunotherapies.
The
review
emphasizes
two
major
aspects:
mechanisms
driving
in
both
how
unique
environments
sites
further
complicate
treatment.
By
targeting
vulnerabilities
at
stages,
new
strategies
could
improve
efficacy
existing
provide
better
outcomes
for
cancer
patients.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
In
situ
tumor
vaccines,
which
utilize
antigens
generated
during
treatment
to
stimulate
a
cancer
patient's
immune
system,
has
become
potential
field
in
immunotherapy.
However,
due
the
immunosuppressive
microenvironment
(ITME),
generation
of
is
always
mild
and
not
sufficient.
Tumor‐resident
intracellular
bacteria
have
been
identified
as
complete
component
contribute
creating
ITME.
Herein,
tumor‐resident
scavenger
designed
induce
enhanced
antitumor
photoimmunotherapy‐driven
vaccines
for
treating
hypoxic
tumors.
This
developed
by
integrating
photosensitizer
CyI
antibiotics
Doxycycline
(Doxy)
into
thermal‐sensitive
tumor‐derived
exosomes
fused
liposomes
(ECDL).
vitro
vivo
results
showed
that
ECDL
could
homologous
target
cells
restrict
respiration
mitochondrial
reduce
hypoxia,
thus
providing
continuous
oxygen
eliminate
both
bacteria,
ablating
primary
inhibiting
metastasis
recurrence.
Moreover,
eliminating
neutralizes
ITME
triggers
production
bacterial‐related
neoantigens,
further
strength
study
provided
versatile
effective
are
promising
local,
abscopal,
metastatic
treatment.
EP Europace,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Ibrutinib,
a
widely
used
anti-cancer
drug,
is
known
to
significantly
increase
the
susceptibility
atrial
fibrillation
(AF).
While
it
recognized
that
drugs
can
reshape
gut
microbiota,
influencing
both
therapeutic
effectiveness
and
adverse
events,
role
of
microbiota
in
ibrutinib-induced
AF
remains
largely
unexplored.
Utilizing
16S
rRNA
gene
sequencing,
fecal
transplantation,
metabonomics,
electrophysiological
examination,
molecular
biology
methodologies,
we
sought
validate
hypothesis
dysbiosis
promotes
ibrutinib-associated
elucidate
underlying
mechanisms.
We
found
ibrutinib
administration
predisposes
rats
AF.
Interestingly,
microbial
transplantation
conferred
increased
rats.
Notably,
induced
decrease
abundance
Lactobacillus
gasseri
(L.
gasseri),
oral
supplementation
L.
or
its
metabolite,
butyrate,
effectively
prevented
from
Mechanistically,
butyrate
inhibits
generation
reactive
oxygen
species
(ROS),
thereby
ameliorating
structural
remodeling.
Furthermore,
demonstrated
inhibited
growth
by
disrupting
intestinal
barrier
integrity.
Collectively,
our
findings
provide
compelling
experimental
evidence
supporting
potential
efficacy
targeting
microbes
preventing
AF,
opening
new
avenues
for
interventions.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 24, 2025
Breast
cancer
is
the
most
common
malignancy
in
women
worldwide.
Changes
microbiota
and
their
metabolites
affect
occurrence
development
of
breast
cancer;
however,
specific
mechanisms
are
not
clear.
Gut
microbes
influence
by
regulating
tumor
immune
response,
estrogen
metabolism,
chemotherapy,
immunotherapy
effects.
It
was
previously
thought
that
there
were
no
microorganisms
tissue,
but
it
now
can
outcome
disease.
This
review
builds
on
existing
research
to
comprehensively
analyze
role
gut
intratumoral
metastasis
cancer.
We
also
explore
potential
function
as
biomarkers
for
prognosis
therapeutic
highlighting
need
further
clarify
causal
relationship
between
hope
provide
new
ideas
directions
methods
treatment.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 25, 2025
Sweeping
contact
with
cancer
continues
to
rise
globally,
which
has
led
advanced
research
on
new
treatment
approaches;
nanotechnology
become
crucial
targeted
therapy.
Within
the
intimate
of
nanomaterials,
Au/Ag
nanostructures
have
emerged
as
highly
attractive
because
their
distinctive
desirable
characteristics
and
prospective
roles
in
diagnosis
well
The
developed
revealed
remarkable
biocompatibility,
optically
recursive
alteration,
magnificently
improved
therapeutic
effects
gold
silver
conjunction
each
other.
This
review
addresses
molecular
systemic
aspects
research,
including
impact
genetic
pathways
use
administration
human
organism.
We
explain
some
related
mechanisms
action,
such
photothermal
therapy
(PTT),
photodynamic
(PDT),
drug
delivery
systems
where
they
display
potential
benefits
towards
offering
a
more
approach
fewer
side
effects.
latest
development
shown
that
prospect
real-time
imaging
biomarker
identification,
owing
this
are
being
viewed
tool
for
individualized
treatment.
However,
there
still
limitations:
challenges
scaling
up,
biological
safety,
bringing
it
clinic.
It
is
therefore
incumbent
upon
these
managements
overcome
hurdles
optimize
impact.
As
result,
current
findings
briefly
reviewed,
directions
discussed
support
revolutionary
role
