Trends in Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
The δ-lactam motif is a privileged pharmacophore in drug design and development. While these biologically relevant molecules could be assembled through two-component cyclization, modular approach to constructing structures via multicomponent reaction with unactivated alkenes as starting materials rare. Herein, we report tandem that integrates alkene-dialkylation radical-involved ring-opening cyclization under single metal-electron-shuttle catalysis, which represents the most expeditious access fluorinated δ-lactams from simple alkenes.
Language: Английский
Citations
0
Processes, Journal Year: 2025, Volume and Issue: 13(4), P. 1170 - 1170
Published: April 12, 2025
Tetrafluoroethylene (TFE), as a key basic chemical raw material, has an irreplaceable position in strategic emerging industries involving high-end materials, electronics, chemicals, and pharmaceuticals. Currently, TFE is industrially produced via the vapor cracking of difluoromonochloromethane (R22). However, there gap between China developed countries tetrafluoroethylene monomer, purity monomer difficult to reach high requirement 99.999%, content impurities that determine nature functional materials high, which leads series problems instability performance special products media loss. To enhance monomers by pyrolysis reactor R22 water vapor, fluid dynamics simulations model were conducted using Ansys Fluent. The was initially constructed Space Claim, followed mesh generation with Fluent Meshing other relevant configurations. Both cold-state thermal-state performed. simulation analyzed effects temperature, flow velocity, turbulence models on turbulent gas mixing processes within model. examined impacts reaction process variations internal turbulence, component distribution, outlet concentrations during actual process. Finally, inlet rate structure optimized. results indicated optimal rates for 0.2–0.3 kg/s 0.4–0.5 kg/s, respectively. In practical production, achieved value after modifying T shape. This study provides new insights into lays foundation further improving monomers.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2025, Volume and Issue: 15(16), P. 12739 - 12745
Published: Jan. 1, 2025
A mild and effective visible-light-induced decarboxylative radical cascade reaction of olefin-containing imidazoles α-fluorinated carboxylic acids, has been developed to afford monofluoromethylated or aryldifluoromethylated polycyclic imidazoles.
Language: Английский
Citations
0
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 19, 2025
A novel Fe-catalyzed alkylative aminosulfonylation of alkenes and alkynes with alkyl halides O-Ts activated hydroxylamines by using Na2S2O4 as a reductant sulfone source has been developed. The metal-electron-shuttle catalysis was discovered to be vital for the highly efficient generation sulfonyl radicals anions without requiring organometallic intermediates. This method provides access sulfonamides from easily available features broad substrate scope.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
Recently, metallaphotoredox-catalyzed alkene dicarbofunctionalization reactions have been extensively investigated. Most cases are related to alkyl-arylation processes by conjugate coupling of alkyl radical precursors and aryl electrophiles across alkenes. By contrast, reported examples alkylvinylation vinyl largely limited. Herein, we represent a three-component aminoalkyl-vinylation alkenes enabled photoredox/nickel catalysis. This redox-neutral protocol exhibits broad substrate scope good chemo-, regio-
Language: Английский
Citations
2
Trends in Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1