The pathobiology of neurovascular aging
Neuron,
Journal Year:
2025,
Volume and Issue:
113(1), P. 49 - 70
Published: Jan. 1, 2025
Language: Английский
Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer’s Disease
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 10964 - 10964
Published: Oct. 11, 2024
Although
Alzheimer’s
disease
(AD)
is
traditionally
viewed
as
a
central
nervous
system
disorder
driven
by
the
cerebral
accumulation
of
toxic
beta-amyloid
(Aβ)
peptide,
new
interpretations
amyloid
cascade
hypothesis
have
led
to
recognition
dynamic
equilibrium
in
which
Aβ
resides
and
importance
peripheral
production
degradation
maintaining
healthy
levels.
Our
review
sheds
light
on
critical
role
organs,
particularly
liver,
metabolism
clearance
circulating
Aβ.
We
explore
mechanisms
transport
across
blood–brain
barrier
(BBB)
via
proteins
such
LRP1
P-glycoprotein.
also
examine
how
mechanisms,
including
enzymatic
phagocytic
activity,
impact
homeostasis.
discusses
potential
therapeutic
strategies
targeting
pathways.
By
enhancing
these
pathways,
we
propose
novel
approach
reducing
burden,
potentially
slowing
AD
progression.
Language: Английский
The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer’s disease comorbidity
H L Li,
No information about this author
Qianqian Yao,
No information about this author
Xueyan Huang
No information about this author
et al.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 25, 2024
Alzheimer’s
disease
(AD)
is
the
leading
type
of
dementia
globally,
characterized
by
a
complex
pathogenesis
that
involves
various
comorbidities.
An
imbalance
in
production
and
clearance
amyloid
β-protein
(Aβ)
peptides
brain
key
pathological
mechanism
AD,
with
glymphatic
system
playing
crucial
role
Aβ
clearance.
Comorbidities
associated
such
as
diabetes,
depression,
hypertension,
not
only
affect
but
also
impair
brain’s
lymphatic
system.
Abnormalities
structure
function
this
further
weaken
capabilities,
presence
comorbidities
may
exacerbate
process.
This
paper
aims
to
review
specific
mechanisms
impaired
via
context
AD
comorbidities,
providing
new
insights
for
prevention
treatment
AD.
Overall,
damage
primarily
focuses
on
aquaporin-4
(AQP4)
perivascular
spaces
(PVS),
suggesting
maintaining
health
help
slow
progression
its
Additionally,
given
ongoing
controversies
regarding
system,
revisits
discusses
principles
characteristics
current
detection
methods
Language: Английский
Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice
Zhongyuan Yu,
No information about this author
Jie Liu,
No information about this author
Zhihao Liu
No information about this author
et al.
Alzheimer s & Dementia,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 30, 2024
The
triggering
receptor
expressed
on
myeloid
cells
2
(TREM2)
arginine-47-histidine
(R47H)
mutation
is
a
significant
risk
for
Alzheimer's
disease
(AD)
with
unclear
mechanisms.
Previous
studies
focused
microglial
amyloid-β
(Aβ)
phagocytosis
less
attention
the
impact
of
TREM2
Language: Английский
Tri-culture modeling of neuroinflammation, neurodegeneration, and neuroprotection
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
The
study
of
neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD),
has
long
been
a
complex
and
challenging
task.
One
the
major
hurdles
in
understanding
these
diseases
is
difficulty
recapitulating
interactions
between
neurons,
astrocytes,
microglia
laboratory
setting.
In
recent
years,
researchers
have
made
significant
progress
developing
triculture
models
that
combine
three
cell
types,
allowing
for
more
accurate
representation
cellular
context
human
brain.
This
commentary
discusses
advancements
importance
using
tri-culture
model
systems
clarifying
pathophysiology
AD
article
by
Kim
et
al.
(2024)
published
Language: Английский