The crucial function of gut microbiota on gut-liver repair

hLife, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Copper–luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 118 - 133

Published: Dec. 11, 2024

Language: Английский

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Inflammation Targeting‐Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes recurrence. Although hydrogel-based therapies have shown potential for repair, challenges remain due to inadequate targeting low hydrogel density, leading ongoing infiltration of harmful substances delayed healing. In this study, an inflammation-targeting-triggered healing (ITTH hydrogel) developed, composed polyvinyl alcohol-alginate microgels (PALMs) a cyclodextrin polymer crosslinker (CPC). This specifically targets inflamed colonic sites crosslinks in situ form dense network. The results demonstrate the ITTH adheres effectively tissue both IBD mouse models human samples. crosslinked network acts like barrier, preventing penetration detrimental such as bacteria small molecules, thereby protecting underlying tissue. Furthermore, significantly improved therapeutic outcomes mice with dextran sulfate sodium (DSS)-induced colitis. These findings suggest promising candidate reconstruction mucosa treatment IBD.

Language: Английский

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Bi2O2Se nanosheets coated with rosmarinic acid for colon-targeted treatment of inflammatory bowel disease

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160230 - 160230

Published: Feb. 1, 2025

Language: Английский

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Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation

Published: Jan. 1, 2025

Language: Английский

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Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Maintain Hepatic Homeostasis Via Gut–Liver Axis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Inflammatory bowel disease (IBD) compromises the intestinal barrier and disrupts gut microbiota, impacting liver function via gut-liver axis, which in turn influences microbiota through lipid metabolites exacerbating IBD. This study introduced a probiotic-based treatment using Lactobacillus acidophilus encapsulated tungsten ion-loaded mesoporous polydopamine (LA@WMPDA) to ameliorate colitis balance enterohepatic homeostasis. After oral administration, encapsulation could protect acidophilus, scavenge reactive oxygen/nitrogen species, released ions would inhibit abnormal Enterobacteriaceae growth during colitis, consequently restoring regulating microbiota. Nontargeted metabolomics transcriptomics analyses showed increased short-chain fatty acids indole derivatives, decreased hepatic metabolism. Pathways associated with immune response, cell migration death, response bacterium significant down-regulation colon transcriptome analysis. Thus, this provided pioneered paradigm for IBD highlighted regulation of liver-related metabolic functions axis.

Language: Английский

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Harnessing Nanoreactors with Coupled Optical and Molecular Modalities for Photoenzymatic Modulation of Active Species in Cancer Photo‐Immunotherapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The dynamic process in tumor ablation requires both the generation of reactive oxygen species (ROS) to elicit immunogenic cell death (ICD) and subsequent reduction ROS levels maintain stimulatory activity signaling proteins recover T cells' immune function. Inspired by regulation mechanism redox homeostasis myeloid-derived suppressor cells high-selectivity alcohols/aldehydes conversions 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) Fe(III) synergistic catalysis, photoenzymatic modulators with contradictory but functions are developed for adaptive photo-immunotherapy cancer. In particular, poly(caffeic acid) (PCA) nanospheres synthesized highly efficient oxidative polymerization CA. obtained π-conjugated structures have an extended absorbance near-infrared (NIR) region, narrow band energy (0.86 eV), low exciton binding (43.56 meV) that lead polymerization-enhanced type I photosensitization photostability. Meanwhile, abundant semiquinone radicals existing PCA bestow them superior antioxidant Under NIR irradiation, elevated superoxide radical yields (3.5-fold compared CA) heat stress robust ICD. When irradiation ceases, active downregulation infiltration lymphocytes increase 2.7-fold conventional photosensitizers. As envisaged, this work demonstrates a novel tactic remodel effective inhibition growth metastasis.

Language: Английский

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Electro‐ and Magneto‐Active Biomaterials for Diabetic Tissue Repair: Advantages and Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance

Language: Английский

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Thermosensitive poly (NVCL-co-GelMA) nanogels as a delivery platform for rectal administration of 5-ASA in ulcerative colitis

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162442 - 162442

Published: April 1, 2025

Language: Английский

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