Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis DOI
Hongqian Liu,

Qiannan Cao,

Yufei Yao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Gene therapy has brought hope for curing major diseases including cancer. However, an efficient and safe delivery system is key successful gene therapy. In this study, PPERD (i.e., OHC‐PEG‐CHO/PEtOx 0.2 ‐PEI 0.73 ‐PRGD 0.07 /DNA), polyoxazoline‐based developed to mediate tumor vascular normalization extracellular matrix (ECM) degradation cancer The aldehyde groups of OHC‐PEG‐CHO can form Schiff base bonds with the amine PER PEtOx ), thereby enabling in situ encapsulation PERD PER/DNA) rapid pH responsiveness tissues. possesses excellent vitro transfection performance good biocompatibility. efficiently accumulate, penetrate, transfect tumors once intravenous administration. effectively normalizes vasculature degradates ECM, enhances infiltration function cytotoxic T lymphocytes, inducing antitumor immune response vivo. Moreover, PPERVH ((i.e., /(pshVEGF+pHAase)) also inhibit recurrence metastasis by triggering durable anti‐tumor memory effect. Furthermore, significantly effectiveness checkpoint blockade‐mediated immunotherapy. This strategy provides a promising paradigm inhibiting growth, recurrence, metastasis.

Language: Английский

Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy DOI Open Access

Minhui Cui,

Mengmeng Zhu, Dongsheng Tang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Language: Английский

Citations

1
Ubiquitination regulation of mitochondrial homeostasis: a new sight for the treatment of gastrointestinal tumors DOI Creative Commons

Bingqian Huang,

Yang Yulin,

Jinming Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 11, 2025

Mitochondrial homeostasis (MH) refers to the dynamic balance of mitochondrial number, function, and quality within cells. Maintaining MH is significant in occurrence, development, clinical treatment Gastrointestinal (GI) tumors. Ubiquitination, as an important post-translational modification mechanism proteins, plays a central role regulation MH. Over past decade, research on by ubiquitination has focused biogenesis, dynamics, Mitophagy, metabolism during these processes. This review summarizes potential therapeutic targets ubiquitin (Ub)-regulated intervention GI

Language: Английский

Citations

0
Transition Metal Oxide Nanohybrid Materials: A Review of Their Structures, Properties, and Applications DOI
Shephrah Olubusola Ogungbesan, Nelson Oshogwue Etafo,

Oluwaseun Hanah Anselm

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142209 - 142209

Published: March 1, 2025

Language: Английский

Citations

0
Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions DOI
Saqib Hussain Hadri, Ahsun Riaz,

Jamal Abid

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: April 30, 2025

Language: Английский

Citations

0
Polyoxazoline‐Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis DOI
Hongqian Liu,

Qiannan Cao,

Yufei Yao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Gene therapy has brought hope for curing major diseases including cancer. However, an efficient and safe delivery system is key successful gene therapy. In this study, PPERD (i.e., OHC‐PEG‐CHO/PEtOx 0.2 ‐PEI 0.73 ‐PRGD 0.07 /DNA), polyoxazoline‐based developed to mediate tumor vascular normalization extracellular matrix (ECM) degradation cancer The aldehyde groups of OHC‐PEG‐CHO can form Schiff base bonds with the amine PER PEtOx ), thereby enabling in situ encapsulation PERD PER/DNA) rapid pH responsiveness tissues. possesses excellent vitro transfection performance good biocompatibility. efficiently accumulate, penetrate, transfect tumors once intravenous administration. effectively normalizes vasculature degradates ECM, enhances infiltration function cytotoxic T lymphocytes, inducing antitumor immune response vivo. Moreover, PPERVH ((i.e., /(pshVEGF+pHAase)) also inhibit recurrence metastasis by triggering durable anti‐tumor memory effect. Furthermore, significantly effectiveness checkpoint blockade‐mediated immunotherapy. This strategy provides a promising paradigm inhibiting growth, recurrence, metastasis.

Language: Английский

Citations

0