Stress Biology, Journal Year: 2024, Volume and Issue: 4(1)
Published: Dec. 9, 2024
Language: Английский
Plant Stress, Journal Year: 2024, Volume and Issue: 11, P. 100427 - 100427
Published: March 1, 2024
Since the beginning of 21st century, climate change has been pervasive. Such climatic instabilities not only trigger plants' adaptability and survivability in harsh environments, but also sustain spread a broad spectrum pathogens including bacteria, fungi, viruses, that create disease pressure by affecting plant health immune barrier. Salicylic acid (SA) is potent phytohormone signaling molecule plays pivotal roles physio-biochemical processes during development. In addition to its widely known role abiotic stress response, SA vital response biotic stresses through their pathways, molecular interactions, corresponding interactions with other phytohormones like jasmonic acid, ethylene, abscisic etc. this perspective, dictated plethora interacting genes, proteins, transcription factors (TFs). The genes genetic regulators (TFs regulatory proteins) are associated fine-tune activating systemic localized cascade, triggering for pathogenesis-related (PR) phytoalexins, etc., modulate pathogen effectors. way, boosts plant's system acquired resistance (SAR) induced (ISR). addition, gene editing epigenetic regulation SA-responsive valuable innovative tools understand decipher complex SA-involved mechanism future utilities make climate-adaptive plants resistance.
Language: Английский
Citations
40
Nature, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract Plants lack specialized and mobile immune cells. Consequently, any cell type that encounters pathogens must mount responses communicate with surrounding cells for successful defence. However, the diversity, spatial organization function of cellular states in pathogen-infected plants are poorly understood 1 . Here we infect Arabidopsis thaliana leaves bacterial trigger or supress integrate time-resolved single-cell transcriptomic, epigenomic transcriptomic data to identify states. We describe cell-state-specific gene-regulatory logic involves transcription factors, putative cis -regulatory elements target genes associated disease immunity. show a rare population emerges at nexus immune-active hotspots, which designate as primary responder (PRIMER) PRIMER have non-canonical signatures, exemplified by expression genome accessibility previously uncharacterized factor, GT-3A, contributes plant immunity against pathogens. surrounded another state (bystander) activates long-distance cell-to-cell signalling. Together, our findings suggest interactions between these propagate across leaf. Our molecularly defined spatiotemporal atlas provides functional regulatory insights into plants.
Language: Английский
Citations
2
Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(4), P. 453 - 465.e6
Published: March 20, 2024
The plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (AtMLKL1) clusters into puncta at the plasma membrane upon TNL activation and this sub-cellular reorganization is dependent on signal transducer, EDS1. We find AtMLKLs confer TNL-triggered immunity parallel with RPW8-type HeLo-domain-containing NLRs (RNLs) AtMLKL N-terminal HeLo indispensable for both clustering. mediates cytoplasmic Ca
Language: Английский
Citations
12
Journal of Experimental Botany, Journal Year: 2024, Volume and Issue: 75(8), P. 2256 - 2265
Published: Jan. 18, 2024
Abstract The mitogen-activated protein kinase (MAPK/MPK) cascade is an important intercellular signaling module that regulates plant growth, development, reproduction, and responses to biotic abiotic stresses. A MAPK usually consists of a (MAPKKK/MEKK), (MAPKK/MKK/MEK), MAPK. well-characterized cascades in immunity date are the MEKK1-MKK1/2-MPK4 MAPKKK3/4/5-MKK4/5-MPK3/6 cascade. Recently, major breakthroughs have been made understanding molecular mechanisms associated with regulation immune by both these cascades. In this review, we highlight most recent advances role activating defense suppressing or fine-tuning signaling. We also discuss which plants stabilize maintain activation during Based on reveal complexity importance cascade, tightly controlled their interacting partners substrates, immunity.
Language: Английский
Citations
10
EMBO Reports, Journal Year: 2023, Volume and Issue: 25(1), P. 31 - 44
Published: Dec. 19, 2023
Abstract To combat microbial pathogens, plants have evolved specific immune responses that can be divided into three essential steps: recognition by receptors, signal transduction within plant cells, and execution directly suppressing pathogens. During the past decades, many receptors signaling components their mode of action been revealed, markedly advancing our understanding first two steps. Activation results in physical chemical actions actually stop pathogen infection. Nevertheless, this third step immunity is under explored. In addition to plants, recent evidence suggests microbiota, which considered an additional layer system, also plays a critical role direct suppression. review, we summarize current how as well microbiota control growth behavior highlight outstanding questions need answered.
Language: Английский
Citations
22
Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2024, Volume and Issue: 51(7), P. 680 - 690
Published: Feb. 26, 2024
Language: Английский
Citations
5
Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(9), P. 1552 - 1565.e8
Published: Aug. 6, 2024
Language: Английский
Citations
5
Microbiological Research, Journal Year: 2024, Volume and Issue: 288, P. 127883 - 127883
Published: Aug. 24, 2024
Bacterial pathogens manipulate host signaling pathways and evade defenses using effector molecules, coordinating their deployment to ensure successful infection. However, host-derived metabolites as signals, critical role in regulating bacterial virulence requires further insights. Effective regulation of virulence, which is essential for pathogenic bacteria, involves controlling factors that enable colonization, defense evasion, tissue damage. This dynamic, influenced by environmental cues including signals from plants like exudates. Plant exudates, comprising diverse compounds released roots tissues, serve rich chemical affecting the behavior associated bacteria. nutrients act molecules are sensed through membrane-localized receptors intracellular response mechanisms review explains how different bacteria detect answer secreted gene expression. Our main emphasis exploring recognition process host-originated molecular sensors on cellular membranes pathways. encompasses insights into strains individually coordinate various distinct can positively or negatively regulate virulence. Furthermore, we explained interruption plant with perception dampen pathogen The intricate interplay between particularly recognize metabolic genes, portrays a crucial initial interaction leading profound influences infection outcomes. work will greatly aid researchers developing new strategies preventing treating infections.
Language: Английский
Citations
4
Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102627 - 102627
Published: Jan. 8, 2025
Language: Английский
Citations
0
Trends in Plant Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0