Systems and synthetic biology for plant natural product pathway elucidation DOI
Kezhen Qin, Fang Liu, Caibin Zhang

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(6), P. 115715 - 115715

Published: May 17, 2025

Language: Английский

From Taxus to paclitaxel: Opportunities and challenges for urban agriculture to promote human health DOI Creative Commons

Xiulan Xie,

Yaohua Zhai,

Hao Cheng

et al.

Plant Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 220, P. 109502 - 109502

Published: Jan. 12, 2025

Language: Английский

Citations

1
Metabolome guided treasure hunt - learning from metabolic diversity DOI Creative Commons
Esra Karakaş, Mustafa Bulut, Alisdair R. Fernie

et al.

Journal of Plant Physiology, Journal Year: 2025, Volume and Issue: 309, P. 154494 - 154494

Published: April 16, 2025

Language: Английский

Citations

0
Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis DOI Creative Commons
Huibin Wang, Ikuro Abe

ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Acetylation introduces acetyl groups to substrates, thus altering their chemical reactivity and stability, plays a crucial role in natural product biosynthesis by driving structural diversification functional optimization. Emerging evidence now highlights cryptic acetylations as transient modifications that guide sequential reactions, enabling the efficient assembly of bioactive molecules. Here, we systematically examine multifaceted roles acetylation‐deacetylation dynamics biosynthesis, with particular emphasis on four key mechanistic paradigms. First, explore strategy acetylation followed deacetylation after several biosynthetic steps, which serves protective directing mechanism. Second, investigate acetylation‐mediated rearrangement, where introduction an group triggers rearrangement generate novel molecular architectures. Third, analyze acetylation‐triggered elimination, process facilitates formation double bonds scaffolds. Finally, discuss cycle regulatory mechanism, highlighting its controlling flux intermediate stability. We also challenges identifying characterizing acetylations, while future opportunities harness these for synthetic biology. By elucidating hidden dynamics, this not only deepens our understanding but provides innovative strategies drug discovery.

Language: Английский

Citations

0
Toward a Taxol-producing microbial cell factory DOI
Vincent Courdavault, Nicolas Papon

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Traditional Chinese medicine for sepsis: advancing from evidence to innovative drug discovery DOI Creative Commons
Yun Ji, Hongyun Song, Libin Li

et al.

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: May 15, 2025

Language: Английский

Citations

0
Systems and synthetic biology for plant natural product pathway elucidation DOI
Kezhen Qin, Fang Liu, Caibin Zhang

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(6), P. 115715 - 115715

Published: May 17, 2025

Language: Английский

Citations

0