Hibecovirus (genus Betacoronavirus) infection linked to gut microbial dysbiosis in bats DOI Creative Commons
Dominik W Melville, Magdalena Meyer, Alice Risely

et al.

ISME Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Little is known about how zoonotic virus infections manifest in wildlife reservoirs. However, a common health consequence of enteric gastrointestinal diseases following shift gut microbial composition. The sub-Saharan hipposiderid bat complex has recently emerged to host at least three coronaviruses (CoVs), with Hipposideros caffer D appearing particularly susceptible Hibecovirus CoV-2B infection. In this study, we complement body condition and infection status data information the community understand impact CoV wild population. Of CoVs, only distantly SARS-related were associated lower altered diversity infected bats became progressively less diverse more dissimilar intensity, arguing for dysbiosis as per Anna-Karenina principle. Putatively beneficial bacteria, such from genera Alistipes Christensenella, decreased while potentially pathogenic namely Mycoplasma Staphylococcus, increased. Infections enterically replicating viruses may therefore cause changes potential negative consequences even We argue that high-resolution on multiple markers, ideally including microbiome information, will provide nuanced picture disease ecology.

Language: Английский

Cytokine Storm in COVID-19: Exploring IL-6 Signaling and Cytokine-Microbiome Interactions as Emerging Therapeutic Approaches DOI Open Access
Tudorița Gabriela Părângă, Ivona Mitu, Mariana Pavel

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11411 - 11411

Published: Oct. 24, 2024

IL-6 remains a key molecule of the cytokine storms characterizing COVID-19, exerting both proinflammatory and anti-inflammatory effects. Emerging research underscores significance trans-signaling over classical signaling pathways, which has shifted focus therapeutic strategies. Additionally, synergistic action TNF-α IFN-γ been found to induce inflammatory cell death through PANoptosis, further amplifying severity storms. Long COVID-19 patients, as well those with triggered by other conditions, exhibit distinct laboratory profiles, indicating need for targeted approaches diagnosis management. Growing evidence also highlights gut microbiota's crucial role in modulating immune response during affecting production, adding complexity disease's immunological landscape. Targeted intervention strategies should on specific cutoffs, though accurate quantification clinical challenge. Current treatment are increasingly focused inhibiting trans-signaling, offers promise more precise manage hyperinflammatory responses COVID-19. In light recent discoveries, this review summarizes findings storms, particularly their conditions. It explores emerging targeting cytokines like IL-6, TNF-α, IFN-γ, while addressing open questions, such better biomarkers detect ongoing challenges developing treatments that mitigate hyperinflammation without compromising function, emphasizing importance continued field.

Language: Английский

Citations

6
Magnesium and Longevity DOI Creative Commons
Patrick Chambers

Published: Nov. 7, 2024

Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. a cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.

Language: Английский

Citations

5
The role of colonic microbiota amino acid metabolism in gut health regulation DOI Creative Commons
Youli Chen, Jing‐Yuan Fang

Cell Insight, Journal Year: 2025, Volume and Issue: unknown, P. 100227 - 100227

Published: Jan. 1, 2025

The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the large intestine is highly heterogeneous and relevant to health. Despite increasing interest, microbial AA remains relatively unexplored. This review highlights recent advances colonic metabolism, including auxotrophies, synthesis, dissimilatory metabolites, their implications health, focusing on major gastrointestinal diseases colorectal cancer, inflammatory bowel disease, irritable syndrome.

Language: Английский

Citations

0
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19 DOI Creative Commons
Patrícia Brito Rodrigues, Vinícius de Rezende Rodovalho, Valentin Sencio

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 2, 2025

Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role age-associated dysbiosis on disease outcomes still elusive. In the current study, we used high-resolution shotgun metagenomics targeted metabolomics to characterize SARS-CoV-2-associated changes in gut microbiota from young (2-month-old) aged (22-month-old) hamsters, valuable model COVID-19. We show that age-related dysfunctions are linked severity long-term sequelae older hamsters. Our data also reveal age-specific composition metabolic activity both phase (day 7 post-infection, D7) recovery (D22) infection. Aged hamsters exhibited most notable shifts plasma profiles. Through an integrative analysis metagenomics, metabolomics, clinical data, identified significant associations between bacterial taxa, metabolites markers group. On D7 (high load lung epithelial damage) D22 (body weight loss fibrosis), numerous amino acids, acid-related molecules, indole derivatives were found correlate with markers. particular, persistent decrease phenylalanine, tryptophan, glutamic acid, indoleacetic acid animals positively correlated poor body and/or fibrosis by D22. younger several taxa (Eubacterium, Oscillospiraceae, Lawsonibacter) (carnosine cis-aconitic acid) associated mild outcomes. These findings support need for microbiome-targeting strategies more effectively manage pneumonia

Language: Английский

Citations

0
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in experimental COVID-19 DOI Open Access
Patrícia Brito Rodrigues, Vinícius de Rezende Rodovalho, Valentin Sencio

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role age-associated dysbiosis on disease outcomes still elusive. In the current study, we used high-resolution shotgun metagenomics targeted metabolomics to characterize SARS-CoV-2-associated changes in gut microbiota from young (2-month-old) aged (22-month-old) hamsters, valuable model COVID-19. We show that age-related dysfunctions are linked severity long-term sequelae older hamsters. Our data also reveal age-specific composition metabolic activity both phase (day 7 post-infection, D7) recovery (D22) infection. Aged hamsters exhibited most notable shifts plasma profiles. Through an integrative analysis metagenomics, metabolomics, clinical data, identified significant associations between bacterial taxa, metabolites markers group. On D7 (high load lung epithelial damage) D22 (body weight loss fibrosis), numerous amino acids, acid-related molecules, indole derivatives were found correlate with markers. particular, persistent decrease phenylalanine, tryptophan, glutamic acid, indoleacetic acid animals positively correlated poor body and/or fibrosis by D22. younger several taxa ( Eubacterium , Oscillospiraceae Lawsonibacter ) (carnosine cis-aconitic acid) associated mild outcomes. These findings support need for microbiome-targeting strategies more effectively manage pneumonia

Language: Английский

Citations

1
Multiomics analysis reveals the potential mechanism of high‐fat diet in dextran sulfate sodium‐induced colitis mice model DOI Creative Commons
Yuyang Zhao,

Zhimin Chen,

Ruiyi Dong

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(10), P. 8309 - 8323

Published: Aug. 30, 2024

Abstract A high‐fat diet (HFD) is recognized as an important contributor to inflammatory bowel disease (IBD). However, the precise underlying mechanism of HFD on IBD remains elusive. This study aimed investigate potential by which affects using 16S rRNA‐sequencing and RNA‐seq technology. Results indicated that HFD‐treated mice exhibited notable alternations in structure composition gut microbiota, with some these being associated pathogenesis IBD. Analysis colon transcriptome revealed 11 hub genes 7 pathways among control, DSS‐induced colitis, + DSS‐treated groups. Further analysis explores relationship between genes, well microbiota. Overall, findings indicate impact colitis may be linked intestinal dysbiosis specific such Abca8b , Ace2 Apoa1 Apoa4 Apoc3 Aspa Dpp4 Maob Slc34a2 Slc7a9 Trpm6 . These results provide valuable insights for determining therapeutic targets addressing HFD‐induced

Language: Английский

Citations

0
Magnesium and Longevity DOI Open Access
Patrick Chambers

Qeios, Journal Year: 2024, Volume and Issue: 6(11)

Published: Nov. 12, 2024

Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for nearly a thousand enzymatic reactions. This narrative review does correlate status with clinical data on agents linked to longevity. The approach more novel highlights specific dependent physiologic reactions by these longevity biomarkers. Many share common pathways extend healthspan. cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented, although cause effect awaits publication supporting data.

Language: Английский

Citations

0
Hibecovirus (genus Betacoronavirus) infection linked to gut microbial dysbiosis in bats DOI Creative Commons
Dominik W Melville, Magdalena Meyer, Alice Risely

et al.

ISME Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Little is known about how zoonotic virus infections manifest in wildlife reservoirs. However, a common health consequence of enteric gastrointestinal diseases following shift gut microbial composition. The sub-Saharan hipposiderid bat complex has recently emerged to host at least three coronaviruses (CoVs), with Hipposideros caffer D appearing particularly susceptible Hibecovirus CoV-2B infection. In this study, we complement body condition and infection status data information the community understand impact CoV wild population. Of CoVs, only distantly SARS-related were associated lower altered diversity infected bats became progressively less diverse more dissimilar intensity, arguing for dysbiosis as per Anna-Karenina principle. Putatively beneficial bacteria, such from genera Alistipes Christensenella, decreased while potentially pathogenic namely Mycoplasma Staphylococcus, increased. Infections enterically replicating viruses may therefore cause changes potential negative consequences even We argue that high-resolution on multiple markers, ideally including microbiome information, will provide nuanced picture disease ecology.

Language: Английский

Citations

0