Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Polyphenol-Containing Feed Additive Polygain™ Reduces Methane Production and Intensity from Grazing Dairy Cows Measured Using an Inverse-Dispersion Technique

Animals, Journal Year: 2025, Volume and Issue: 15(7), P. 926 - 926

Published: March 24, 2025

This study, conducted on a commercial dairy farm using robotic milking system in Victoria, Australia, examined the effects of Polygain™ (The Product Makers Australia), polyphenol-rich sugarcane feed material (PRSFM), CH4 emissions grazing cattle an inverse-dispersion model (IDM) combined with open-path laser techniques. Thirty lactating Holstein Friesian cows (aged 2-5 years average body weight 663 kg and daily milk production 28.9 kg) were divided into two dietary treatment groups fifteen each. Before measurement, PRSFM (0.25%) was supplemented for 3 weeks as adaptation period mixed pellet group. Over 2-week measurement period, (MP) 495 ± 12 377 (mean standard error) g CH4/animal/day control groups, respectively. Methane intensity (MI) 17.04 13.01 CH4/animal/kg milk/day On average, Polygain supplementation reduced MP MI by 24%. potential reduction extrapolated across Australia contributes to 2.63% national agricultural emissions. study underscores mitigation cattle.

Language: Английский

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Liver Neurobiology: Regulation of Liver Functions by the Nervous System

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

The nervous system plays an important role in the regulation of liver functions during physiological as well pathological conditions. This regulatory effect is based on processing signals transmitted to brain by sensory nerves innervating tissue and other visceral organs humoral pathways transmitting from peripheral tissues organs. Based these signals, modulates metabolism, detoxification, regeneration, repair, inflammation, processes occurring liver. thus determines functional morphological characteristics Liver innervation also mediates influence psychosocial factors functions. aim this review describe complexity bidirectional interactions between characterize mechanisms through which influences function conditions maintains systemic homeostasis.

Language: Английский

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Microcystin-LR Induces Lipid Metabolism Disorder in Pelophylax nigromaculatus Tadpoles via the Gut–Liver Axis

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Disruption of lipid homeostasis in aquatic animals poses serious health risks, including tissue damage and systemic metabolic dysfunction. The precise mechanisms by which microcystin-LR, a potent cyanotoxin, disrupts metabolism amphibian tadpoles remain unclear. In this study, (Pelophylax nigromaculatus) were exposed to MC-LR fecal microbiota transplantation (FMT) experiments performed investigate whether or how at environmental concentrations interfered with tadpole from the perspective gut microbiota-gut-liver axis. Following exposure, liver exhibited significant inflammation, hypertrophy, fibrosis, accompanied elevated serum levels. Furthermore, expression levels farnesoid X receptor (FXR), nuclear receptor, significantly downregulated. Molecular docking molecular dynamics simulations indicated strong stable binding between FXR MC-LR. Moreover, suppressed activity, triggering: (1) upregulation sterol regulatory element-binding protein 1 (SREBP1)-mediated triglyceride (TG) synthesis, (2) inhibition free fatty acid (FFA) β-oxidation, (3) activation SREBP2-dependent bile biosynthesis. altered composition specific (e.g., taurocholic glycochenodeoxycholic acid) gut, thereby interfering hepatic metabolism, as evidenced FMT-induced accumulation recipient tadpoles. These findings identify potentially key target for suggest that changes intestinal also may be an important pathway driving dysregulation amphibians

Language: Английский

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In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103674 - 103674

Published: May 1, 2025

Language: Английский

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In vitro simulated digestion and fermentation characteristics of pumpkin polysaccharides and their effects on the human gut microbiota

Food Chemistry, Journal Year: 2025, Volume and Issue: 489, P. 144976 - 144976

Published: June 1, 2025

Language: Английский

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